Personal profile
Primary fields of research
Sudden cardiac death (SCD) in the young is often caused by inherited cardiac diseases. The two main types of diseases associated with SCD are cardiomyopathies and channelopathies. It is, though, challenging to determine the cause of death in cases with channelopathies as these diseases do not induce structural changes of cardiac tissue. Genetic investigations, a so-called molecular autopsy, may aid in determining the cause of death by identifying genetic variation that caused the disease. This knowledge can also be used to evaluate the risk of SCD in relatives.
Current research
- Investigation of heart genes in young individuals (<50 years) that died suddenly and unexpectedly and where the cause of death was unexplained or suspected cardiac disease following autopsy
- Evaluation of gene expression levels in the heart of sudden cardiac death victims
Education/Academic qualification
Biomedicine, MSc, University of Southern Denmark (SDU)
2016 → 2018
Biomedicine, BSc, University of Southern Denmark (SDU)
2013 → 2016
Keywords
- Faculty of Health and Medical Sciences
- Sudden Cardiac Death in the young
- Massively Parallel Sequencing
Collaborations and top research areas from the last five years
Research output
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CALM1, CALM2, and CALM3 expression and translation efficiency provide insight into the severity of calmodulinopathy
Christiansen, S. N. N., Jacobsen, S. B., Andersen, J. D., Cui, Y., Li, W., Staehr, C., Andersen, M. M., Crotti, L., Spazzolini, C., Schwartz, P. J., Nyegaard, M. & Overgaard, M. T., 2026, In: Europace. 28, 4, 10 p., euag052.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Downloads (Pure) -
Quantitative Histological Insights Into Sudden Arrhythmic Death Syndrome: Findings From a Forensic Autopsy Cohort
Holm, P. H., Jensen, T. H. L., Westaby, J., Sheppard, M. N., Jacobsen, S. B., Dupont, M. E., Andersen, J. D., Winkel, B. G., Tfelt-Hansen, J., Banner, J. & Olsen, K. B., 2026, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 134, 3, e70169.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile25 Downloads (Pure) -
Regional and Socioeconomic Disparities in the Diagnosis of Primary Electrical Diseases in a Universal Healthcare System: A Nationwide Danish Study
Bhardwaj, P., Winkel, B. G., Dinesen, R. B., Torp-Pedersen, C., Jacobsen, S. B., Wilde, A. A. M., Hansen, C. J. & Tfelt-Hansen, J., 2026, (E-pub ahead of print) In: European heart journal. Quality of care & clinical outcomes.Research output: Contribution to journal › Journal article › Research › peer-review
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Current perspectives on risk prediction and genetic basis of Brugada syndrome
Bhardwaj, P., Stavnem, D., Jacobsen, S. B., Winkel, B. G. & Tfelt-Hansen, J., 2025, In: Frontiers in Cardiovascular Medicine. 12, 7 p., 1722105.Research output: Contribution to journal › Review › peer-review
Open AccessFile18 Downloads (Pure) -
DNA methylation alterations of PITX2 and PANCR are associated with left-right asymmetry of the heart and left ventricle size
Christiansen, S. N. N., Olsen, K. B., Larsen, S. T., Holm, P. H., Palsøe, M. K., Kampmann, M.-L., Jacobsen, S. B., Andersen, M. M., Banner, J., Morling, N., Tfelt-Hansen, J. & Andersen, J. D., 28 Aug 2025, medRxiv, 23 p.Research output: Working paper › Preprint
File2 Downloads (Pure) -
Editorial commentary: "Three steps to ACM diagnosis - is it that easy?"
Bhardwaj, P., Jacobsen, S. B. & Tfelt-Hansen, J., 2025, In: Trends in Cardiovascular Medicine. 35, 2, p. 114-115Research output: Contribution to journal › Comment/debate › Research › peer-review
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Forensic investigative genetic genealogy using genotypes generated or imputed from transcriptomes
Kling, D., Jepsen, A. H., Kampmann, M. L., Jacobsen, S. B., Tillmar, A., Børsting, C. & Andersen, J. D., 2025, In: Forensic Science International: Genetics. 78, 9 p., 103277.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)26 Downloads (Pure) -
RNA degradation patterns in cardiac tissues kept at different time intervals and temperatures before RNA sequencing
Jacobsen, S. B., Tfelt-Hansen, J., Smerup, M. H., Morling, N. & Andersen, J. D., 2025, In: PLoS ONE. 20, 5 , 14 p., e0323786.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)17 Downloads (Pure)
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Forensic molecular autopsies in cases of sudden cardiac death
Jacobsen, S. B. (Invited speaker)
20 Jun 2024 → 22 Jun 2024Activity: Presentations, memberships and other activity types › Lecture and oral contribution
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10th Biennial Meeting of the Association for European Cardiovascular Pathology
Jacobsen, S. B. (Speaker)
21 Sept 2023 → 23 Sept 2023Activity: Participating in an event - types › Participation in workshop, seminar, course
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31st Conference on Intelligent Systems for Molecular Biology and the 22nd European Conference on Computational Biology
Jacobsen, S. B. (Participant)
23 Jul 2023 → 27 Jul 2023Activity: Participating in an event - types › Participation in workshop, seminar, course
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Årskursus 2022 i Dansk Selskab for Retsmedicin
Jacobsen, S. B. (Speaker)
3 Nov 2022 → 5 Nov 2022Activity: Participating in an event - types › Participation in workshop, seminar, course
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EHRA 2022
Jacobsen, S. B. (Participant)
3 Apr 2022 → 5 Apr 2022Activity: Participating in an event - types › Participation in workshop, seminar, course
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ELIXIR 6th Annual Danish Bioinformatics Conference
Jacobsen, S. B. (Participant)
18 Nov 2021 → 19 Nov 2021Activity: Participating in an event - types › Participation in workshop, seminar, course
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Whole genome and transcriptome sequencing of post-mortem cardiac tissues from sudden cardiac death victims
Jacobsen, S. B. (Speaker)
4 Dec 2019Activity: Presentations, memberships and other activity types › Lecture and oral contribution
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14th Meeting of the Myocardial and Pericardial Diseases Working Group of the European Society of Cardiology
Jacobsen, S. B. (Participant)
26 Oct 2017 → 28 Oct 2017Activity: Participating in an event - types › Participation in workshop, seminar, course