Research output per year
Research output per year
Research output
- 1 - 50 out of 183 results
Search results
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2024
Acid–base transporters in the context of tumor heterogeneity
Pedersen, S. H. F., 2024, In: Pflugers Archiv European Journal of Physiology. 476, p. 689–701 13 p.Research output: Contribution to journal › Review › Research › peer-review
1 Citation (Scopus) -
Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance
Stigliani, A., Ialchina, R., Yao, J., Czaplinska, D., Dai, Y., Andersen, H. B., Rennie, S., Andersson, R., Pedersen, S. F. & Sandelin, A., 2024, In: Cell Reports. 43, 7, 24 p., 114409.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Rezi, C. K., G. Aslanyan, M., D. Diwan, G., Cheng, T., Chamlali, M., Junger, K., Anvarian, Z., Lorentzen, E., Pauly, K. B., Afshar-Bahadori, Y., Alves Fernandes, E. F., Qian, F., Tosi, S., Christensen, S. T., Pedersen, S. H. F., Strømgaard, K., B. Russell, R., H. Miner, J., R. Mahjoub, M., Boldt, K. & 2 others, , 2024, In: E M B O Reports. 25, 7, p. 3040-3063 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Downloads (Pure) -
MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells
Meng, S., Sørensen, E. E., Ponniah, M., Thorlacius-Ussing, J., Crouigneau, R., Larsen, T., Borre, M. T., Willumsen, N., Flinck, M. & Pedersen, S. F., 2024, In: Journal of Cell Science. 137, 8, 15 p., jcs261608.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Downloads (Pure) -
Mimicking and analyzing the tumor microenvironment
Crouigneau, R., Li, Y., Auxillos, J., Goncalves-Alves, E., Marie, R., Sandelin, A. & Pedersen, S. F., 2024, In: Cell Reports Methods. 4, 10, 17 p., 100866.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile2 Citations (Scopus)1 Downloads (Pure) -
Na+/H+-exchange inhibition by cariporide is compensated via Na+,HCO3−-cotransport and has no net growth consequences for ErbB2-driven breast carcinomas
Aaen, P., Kristensen, K. B., Antony, A., Hansen, S. H., Cornett, C., Pedersen, S. F. & Boedtkjer, E., 2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 7, 13 p., 167450.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Downloads (Pure) -
NHE1 regulation in NAFLD in vitro contributes to hepatocyte injury and HSC crosstalk
Sjøgaard-Frich, L. M., Henriksen, M. S., Lam, S. M., Birkbak, F. J., Czaplinska, D., Flinck, M. & Pedersen, S. F., 2024, In: The Journal of endocrinology. 263, 2, 15 p., e240099.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of cancer cell lipid metabolism and oxidative phosphorylation by microenvironmental acidosis
Rolver, M. G., Severin, M. & Pedersen, S. F., 2024, In: American Journal of Physiology - Cell Physiology. 327, 4, p. C869-C883 15 p.Research output: Contribution to journal › Review › Research › peer-review
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Spatially resolved analysis of microenvironmental gradient impact on cancer cell phenotypes
Auxillos, J., Crouigneau, R., Li, Y. F., Dai, Y., Stigliani, A., Tavernaro, I., Resch-Genger, U., Sandelin, A., Marie, R. & Pedersen, S. F., 2024, In: Science Advances. 10, 18, 17 p., eadn3448.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)13 Downloads (Pure) -
Transmembrane transporter proteins: Capturing transport in motion
Loland, C. J., Wellendorph, P., Pedersen, S. F. & Gether, U., 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
Open AccessFile1 Downloads (Pure) -
2023
Aquaporin water channels affect the response of conventional anticancer therapies of 3D grown breast cancer cells
Edamana, S., Pedersen, S. F. & Nejsum, L. N., 2023, In: Biochemical and Biophysical Research Communications. 639, p. 126-133 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)29 Downloads (Pure) -
Chronic acidosis rewires cancer cell metabolism through PPARα signaling
Rolver, M. G., Holland, L. K. K., Ponniah, M., Prasad, N. S., Yao, J., Schnipper, J., Kramer, S., Elingaard-Larsen, L., Pedraz-Cuesta, E., Liu, B., Pardo, L. A., Maeda, K., Sandelin, A. & Pedersen, S. F., 2023, In: International Journal of Cancer. 152, 8, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile29 Citations (Scopus)55 Downloads (Pure) -
Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness
Czaplinska, D., Ialchina, R., Andersen, H. B., Yao, J., Stigliani, A., Dannesboe, J., Flinck, M., Chen, X., Mitrega, J., Gnosa, S. P., Dmytriyeva, O., Alves, F., Napp, J., Sandelin, A. & Pedersen, S. F., 2023, In: International Journal of Cancer. 152, 6, p. 1210-1225 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)44 Downloads (Pure) -
Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia
Severin, M., Pedersen, E. L., Borre, M. T., Axholm, I., Christiansen, F. B., Ponniah, M., Czaplinska, D., Larsen, T., Pardo, L. A. & Pedersen, S. F., 2023, In: Journal of Cell Science. 136, 7, 20 p., jcs260687.Research output: Contribution to journal › Journal article › Research › peer-review
File7 Citations (Scopus) -
Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison
Panou, D. A., Pedersen, S. H. F., Kristensen, M. & Nielsen, H. M., 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile24 Downloads (Pure) -
How protons pave the way to aggressive cancers
Swietach, P., Boedtkjer, E. & Pedersen, S. F., 2023, In: Nature Reviews Cancer. 23, p. 825-841 17 p.Research output: Contribution to journal › Review › Research › peer-review
31 Citations (Scopus) -
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Lundø, K., Dmytriyeva, O., Spøhr, L., Goncalves-Alves, E., Yao, J., Blasco, L. P., Trauelsen, M., Ponniah, M., Severin, M., Sandelin, A., Kveiborg, M., Schwartz, T. W. & Pedersen, S. F., 2023, In: BMC Cancer. 23, 1, 20 p., 1136.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)38 Downloads (Pure) -
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, K., Pedersen, S. F., Arleth, L. & Kragelund, B. B., 2023, In: eLife. 12, 27 p., e84645.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)19 Downloads (Pure) -
2022
Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca2+ Entry and Interaction with PI3K/CaM
Schnipper, J., Kouba, S., Hague, F., Girault, A., Telliez, M-S., Guenin, S., Ahidouch, A., Pedersen, S. F. & Ouadid-Ahidouch, H., 2022, In: Cancers. 14, 19, 27 p., 4946.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)17 Downloads (Pure) -
How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression
Elingaard-Larsen, L. O., Rolver, M. G., Sørensen, E. E. & Pedersen, S. F., 2022, From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Stock, C. & Pardo, L. A. (eds.). Springer, p. 1-38 38 p. (Reviews of Physiology, Biochemistry and Pharmacology, Vol. 182).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
7 Citations (Scopus) -
Sialylation of N-glycans affects the lipid secretion governed by specialized secretory lysosomal organelles through an effect on the V-ATPase
Khoder-Agha, F., Song, M., Borre, M. T., Marinova, I. N., Ye, Z., Pedersen, S. F., Dabelsteen, S. & Wandall, H. H., 2022, In: Glycobiology. 32, 11, p. 1012-1013 2 p., P103.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Open Access -
The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner
Schnipper, J., Kouba, S., Hague, F., Girault, A., Rybarczyk, P., Telliez, M-S., Guenin, S., Tebbakha, R., Sevestre, H., Ahidouch, A., Pedersen, S. F. & Ouadid-Ahidouch, H., 2022, In: International Journal of Molecular Sciences . 23, 14, 20 p., 7923.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)14 Downloads (Pure) -
2021
Dynamic Na+/H+ exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation
Sjøgaard-Frich, L. M., Prestel, A., Pedersen, E. S., Severin, M., Kristensen, K. K., Olsen, J. G., Kragelund, B. B. & Pedersen, S. F., 2021, In: eLife. 10, 29 p., e60889.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Citations (Scopus)80 Downloads (Pure) -
Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
Andersen, H. B., Ialchina, R., Pedersen, S. F. & Czaplinska, D., 2021, In: Cancer and Metastasis Reviews. 40, 4, p. 1093-1114 22 p.Research output: Contribution to journal › Review › Research › peer-review
14 Citations (Scopus) -
Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer
Rolver, M. G. & Pedersen, S. F., 2021, In: British Journal of Cancer. 124, p. 1-2 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
Open AccessFile6 Citations (Scopus)33 Downloads (Pure) -
The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
Pedersen, S. F., Flinck, M. & Pardo, L. A., 2021, In: International Journal of Molecular Sciences. 22, 10, 27 p., 5209.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile16 Citations (Scopus)28 Downloads (Pure) -
The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells
Doray, A., Lemoine, R., Severin, M., Chadet, S., Lopez-Charcas, O., Héraud, A., Baron, C., Besson, P., Monteil, A., Pedersen, S. F. & Roger, S., 2021, In: Cells. 10, 7, 15 p., 1624.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)16 Downloads (Pure) -
2020
Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion
Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, B., Pedersen, S. F., Rheinstädter, M. C., Langkilde, A. E. & Kragelund, B. B., 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile28 Citations (Scopus)99 Downloads (Pure) -
Cancer Cell Acid Adaptation Gene Expression Response is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival
Yao, J., Czaplinska, D., Ialchina, R., Schnipper, J., Liu, B., Sandelin, A. & Pedersen, S. F., 2020, In: Cancers. 12, 8, 27 p., 2183.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile24 Citations (Scopus)85 Downloads (Pure) -
O-glycan initiation directs distinct biological pathways and controls epithelial differentiation
Bagdonaite, I., Pallesen, E. M. H., Ye, Z., Vakhrushev, S. Y., Marinova, I. N., Nielsen, M. I., Kramer, S. H., Pedersen, S. F., Joshi, H. J., Bennett, E. P., Dabelsteen, S. & Wandall, H. H., 2020, In: EMBO Reports. 21, 6, 17 p., e48885.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile38 Citations (Scopus)88 Downloads (Pure) -
Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1
Rolver, M. G., Elingaard-Larsen, L. O., Andersen, A. P., Counillon, L. & Pedersen, S. F., 2020, In: Scientific Reports. 10, 17 p., 5800.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile43 Citations (Scopus)91 Downloads (Pure) -
TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling
Malinda, R. R., Zeeberg, K., Sharku, P. C., Ludwig, M. Q., Pedersen, L. B., Christensen, S. T. & Pedersen, S. F., 2020, In: Frontiers in Oncology. 10, 15 p., 687.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Citations (Scopus)98 Downloads (Pure) -
The Acidic Tumor Microenvironment as a Driver of Cancer
Boedtkjer, E. & Pedersen, S. F., 2020, In: Annual Review of Physiology. 82, p. 103-126Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile707 Citations (Scopus) -
The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity
Hendus-Altenburger, R., Vogensen, J., Pedersen, E. S., Luchini, A., Araya-Secchi, R., Bendsoe, A. H., Prasad, N. S., Prestel, A., Cardenas, M., Pedraz-Cuesta, E., Arleth, L., Pedersen, S. H. F. & Kragelund, B. B., 3 Dec 2020, In: Communications Biology . 3, 1, 18 p., 731.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Citations (Scopus)71 Downloads (Pure) -
The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells
Flinck, M., Hagelund, S., Gorbatenko, A., Severin, M., Pedraz-Cuesta, E., Novak, I., Stock, C. & Pedersen, S. F., 2020, In: Cells. 9, 2, 22 p., 465.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile17 Citations (Scopus)81 Downloads (Pure) -
The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4
Thiesen, L., Belew, Z. M., Griem-Krey, N., Pedersen, S. F., Crocoll, C., Nour-Eldin, H. H. & Wellendorph, P., 15 Feb 2020, In: European Journal of Pharmaceutical Sciences. 143, p. 1-9 105203.Research output: Contribution to journal › Journal article › Research › peer-review
4 Citations (Scopus) -
Why Warburg Works: Lactate Controls Immune Evasion through GPR81
Larsen, K. L., Trauelsen, M., Pedersen, S. H. F. & Schwartz, T. W., 2020, In: Cell Metabolism. 31, 4, p. 666–668 3 p.Research output: Contribution to journal › Letter › Research › peer-review
Open Access42 Citations (Scopus) -
Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies
Kassem, N., Kassem, M. M., Pedersen, S. F., Pedersen, P. A. & Kragelund, B. B., 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)140 Downloads (Pure) -
2019
3D multicellular models to study the regulation and roles of acid-base transporters in breast cancer
Czaplinska, D., Elingaard-Larsen, L. O., Rolver, M. G., Severin, M. & Pedersen, S. F., 20 Dec 2019, In: Biochemical Society Transactions. 47, 6, p. 1689-1700 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
6 Citations (Scopus) -
Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer
Avnet, S., Baldini, N., Brisson, L., Pedersen, S. F., Porporato, P. E., Sonveaux, P., Szabadkai, G. & Pastorekova, S., 2019, In: Frontiers in Oncology. 9, 5 p., 1332.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile2 Citations (Scopus)71 Downloads (Pure) -
Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells
Rolver, M. G., Elingaard-Larsen, L. O. & Pedersen, S. F., 2019, In: Journal of Visualized Experiments. 2019, 148, e59714.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access35 Citations (Scopus) -
Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Tornabene, E., Helms, H. C. C., Pedersen, S. F. & Brodin, B., 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile41 Citations (Scopus)127 Downloads (Pure) -
HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503
Gorbatenko, A., Søkilde, R., Sorensen, E. E., Newie, I., Persson, H., Morancho, B., Arribas, J., Litman, T., Rovira, C. & Pedersen, S. F., 2019, In: Scientific Reports. 9, 1, p. 1-16 3352.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Citations (Scopus)155 Downloads (Pure) -
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, L. M., Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, B. B., Pedersen, S. F. & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile35 Citations (Scopus)148 Downloads (Pure) -
Profibrotic epithelial phenotype: a central role for MRTF and TAZ
Bialik, J. F., Ding, M., Speight, P., Dan, Q., Miranda, M. Z., Di Ciano-Oliveira, C., Kofler, M. M., Rotstein, O. D., Pedersen, S. F., Szászi, K. & Kapus, A., 2019, In: Scientific Reports. 9, p. 1-14 4323.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile30 Citations (Scopus)139 Downloads (Pure) -
The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration
Jensen, H. H., Pedersen, G. A., Morgen, J. J., Parsons, M., Pedersen, S. F. & Nejsum, L. N., 2019, In: Journal of Physiology. 597, 3, p. 849-867Research output: Contribution to journal › Journal article › Research › peer-review
Open Access18 Citations (Scopus) -
The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology
Pedersen, S. F. & Counillon, L., 2019, In: Physiological Reviews. 99, 4, p. 2015-2113 99 p.Research output: Contribution to journal › Review › Research › peer-review
120 Citations (Scopus) -
2018
Na+,HCO3--cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice
Lee, S., Axelsen, T. V., Jesse, N., Pedersen, S. F., Vahl, P. & Boedtkjer, E., 2018, In: Oncogene. 37, 41, p. 5569-5584Research output: Contribution to journal › Journal article › Research › peer-review
40 Citations (Scopus) -
Roles of pH in control of cell proliferation
Flinck, M., Kramer, S. H. & Pedersen, S. H. F., 2018, In: Acta Physiologica. 223, 3, p. 1-17 e13068.Research output: Contribution to journal › Review › Research › peer-review
113 Citations (Scopus) -
The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells
Flinck, M., Kramer, S. H., Schnipper, J., Andersen, A. P. & Pedersen, S. F., 2018, In: Cell Cycle. 17, 9, p. 1056-1067Research output: Contribution to journal › Journal article › Research › peer-review
Open Access48 Citations (Scopus)