Thomas Andrew Qvistgaard Jepps

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• 2024

  Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation

  Forrester, E. A., Benítez-Angeles, M., Redford, K. E., Rosenbaum, T., Abbott, G. W., Barrese, V., Dora, K., Albert, A. P., Dannesboe, J., Salles-Crawley, I., Jepps, T. A. & Greenwood, I. A., 2024, (E-pub ahead of print) In: Cardiovascular Research.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation

  Mozzicato, A. M., Bastrup, J. A., Sanchez-Alonso, J. L., van der Horst, J., Gorelik, J., Hägglund, P. & Jepps, T. A., 2024, In: The Biochemical journal. 481, 5, p. 387-403

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  1 Citation (Scopus)

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• Polymodal K⁺ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines

  Manville, R. W., Yoshimura, R. F., Yeromin, A. V., Hogenkamp, D., van der Horst, J., Zavala, A., Chinedu, S., Arena, G., Lasky, E., Fisher, M., Tracy, C. R., Othy, S., Jepps, T. A., Cahalan, M. D. & Abbott, G. W., 2024, In: Communications Biology . 7, 1, 18 p., 1059.

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• Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1

  Bankell, E., Liu, L., van der Horst, J., Rippe, C., Jepps, T. A., Nilsson, B. O. & Swärd, K., 2024, In: Scientific Reports. 14, 1, 19 p., 13321.

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  1 Citation (Scopus)

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• Vascular smooth muscle BK channels limit ouabain-induced vasocontraction: Dual role of the Na/K-ATPase as a hub for Src-kinase and the Na/Ca-exchanger

  Orth, T., Pyanova, A., Lux, S., Kaiser, P., Reinheimer, I., Nielsen, D. L., Khalid, J. A., Rognant, S., Jepps, T. A., Matchkov, V. V. & Schubert, R., 2024, In: FASEB Journal. 38, 17, 16 p., e70046.

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• 2023

  Acute, pro-contractile effects of prorenin on rat mesenteric arteries

  Rognant, S., Baldwin, S. N., Pritchard, H. A. T., Greenstein, A., Calloe, K., Aalkjaer, C. & Jepps, T. A., 2023, In: FASEB Journal. 37, 12, 18 p., e23282.

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• Colchicine enhances β adrenoceptor-mediated vasodilation in men with essential hypertension

  Ehlers, T. S., van der Horst, J., Møller, S., Piil, P. K., Gliemann, L., Aalkjær, C., Jepps, T. A. & Hellsten, Y., 2023, In: British Journal of Clinical Pharmacology. 89, 7, p. 2179-2189 11 p.

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  2 Citations (Scopus)

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• Cycling matters: Sex hormone regulation of vascular potassium channels

  Baldwin, S. N., Jepps, T. A. & Greenwood, I. A., 2023, In: Channels. 17, 1, 19 p., 2217637.

  Research output: Contribution to journal › Review › Research › peer-review

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  4 Citations (Scopus)

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• Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels

  Manville, R. W., Baldwin, S. N., Eriksen, E. Ø., Jepps, T. A. & Abbott, G. W., 2023, In: FASEB Journal. 37, 9, p. 1-15 e23125.

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  3 Citations (Scopus)

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• Proteomic mapping reveals dysregulated angiogenesis in the cerebral arteries of rats with early-onset hypertension

  Bastrup, J. A. & Jepps, T. A., 2023, In: Journal of Biological Chemistry. 299, 10, p. 1-16 105221.

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  1 Citation (Scopus)

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• Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta

  Arévalo Martínez, M., Ritsvall, O., Bastrup, J. A., Celik, S., Jakobsson, G., Daoud, F., Winqvist, C., Aspberg, A., Rippe, C., Maegdefessel, L., Schiopu, A., Jepps, T. A., Holmberg, J., Swärd, K. & Albinsson, S., 2023, In: JCI insight. 8, 17, 25 p., e170845.

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  10 Citations (Scopus)

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• 2022

  Dynein coordinates β2-adrenoceptor-mediated relaxation in normotensive and hypertensive rat mesenteric arteries

  van der Horst, J., Rognant, S., Hellsten, Y., Aalkjær, C. & Jepps, T. A., 2022, In: Hypertension. 79, 10, p. 2214-2227 14 p.

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  6 Citations (Scopus)

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• Identification of novel proteins and mechanistic pathways associated with early-onset hypertension by deep proteomic mapping of resistance arteries

  Bastrup, J. A., Aalkjær, C. & Jepps, T. A., 2022, In: Journal of Biological Chemistry. 298, 1, 17 p., 101512.

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  10 Citations (Scopus)

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• KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine

  Manville, R. W., Redford, K. E., van der Horst, J., Hogenkamp, D. J., Jepps, T. A. & Abbott, G. W., 2022, In: FASEB Journal. 36, 9, 15 p., e22457.

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  6 Citations (Scopus)

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• The impact of an atrial septal defect on the progression of atrial tachypacing-induced atrial fibrillation in a Danish Landrace pig: A case report

  Saljic, A., Norup Hertel, J., Leonhardt, C., Dalgas Nissen, S., Dobrev, D., Jepps, T. A., Jespersen, T. & Michael Sattler, S., 2022, In: IJC Heart and Vasculature. 40, 3 p., 101054.

  Research output: Contribution to journal › Letter › Research › peer-review

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• The microtubule network enables Src kinase interaction with the Na,K-ATPase to generate Ca²⁺ flashes in smooth muscle cells

  Rognant, S., Kravtsova, V. V., Bouzinova, E. V., Melnikova, E. V., Krivoi, I. I., Pierre, S. V., Aalkjaer, C., Jepps, T. A. & Matchkov, V. V., 2022, In: Frontiers in Physiology. 13, 14 p., 1007340.

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  5 Citations (Scopus)

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• 2021

  Dynein regulates Kv7.4 channel trafficking from the cell membrane

  van der Horst, J., Rognant, S., Abbott, G. W., Ozhathil, L. C., Hägglund, P., Barrese, V., Chuang, C. Y., Jespersen, T., Davies, M. J., Greenwood, I. A., Gourdon, P., Aalkjær, C. & Jepps, T. A., 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.

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  15 Citations (Scopus)

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• Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology

  Jepps, T. A., Barrese, V. & Miceli, F., 2021, In: Frontiers in Physiology. 12, 4 p., 679317.

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  10 Citations (Scopus)

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• Functional sympatholysis in mouse skeletal muscle involves sarcoplasmic reticulum swelling in arterial smooth muscle cells

  van der Horst, J., Møller, S., Kjeldsen, S. A. S., Wojtaszewski, J., Hellsten, Y. & Jepps, T. A., 2021, In: Physiological Reports. 9, 23, 10 p., e15133.

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  3 Citations (Scopus)

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• KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea

  Redford, K. E., Rognant, S., Jepps, T. A. & Abbott, G. W., 2021, In: Cellular Physiology and Biochemistry. 55, S3, p. 46-64 19 p.

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  15 Citations (Scopus)

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• Kv7 channel trafficking by the microtubule network in vascular smooth muscle

  Jepps, T. A., 2021, In: Acta Physiologica. 232, 3, 12 p., e13692.

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  4 Citations (Scopus)

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• 2020

  Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly

  Van Der Horst, J., Manville, R. W., Hayes, K., Thomsen, M. B., Abbott, G. W. & Jepps, T. A., 2020, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 40, 5, p. 1207-1219 13 p.

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  22 Citations (Scopus)

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• Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

  van der Horst, J., Greenwood, I. A. & Jepps, T. A., 2020, In: Frontiers in Physiology. 11, 12 p., 727.

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  33 Citations (Scopus)

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• Effects of a novel selenium substituted-sugar (1,4-anhydro-4-seleno-D-talitol, SeTal) on human coronary artery cell lines and mouse aortic rings

  Zacharias, T., Flouda, K., Jepps, T. A., Gammelgaard, B., Schiesser, C. H. & Davies, M. J., 2020, In: Biochemical Pharmacology. 173, 14 p., 113631.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse

  Hadji-Turdeghal, K., Andreasen, L., Hagen, C. M., Ahlberg, G., Ghouse, J., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Hedley, P., Haunsø, S., Svendsen, J. H., Kanters, J. K., Jepps, T. A., Skov, M. W., Christiansen, M. & Olesen, M. S., 2020, In: Cardiovascular Research. 116, 1, p. 138-148

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  15 Citations (Scopus)

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• 2019

  Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia

  David, J-P., Lisewski, U., Crump, S. M., Jepps, T. A., Bocksteins, E., Wilck, N., Lossie, J., Roepke, T. K., Schmitt, N. & Abbott, G. W., Feb 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 2, p. 2537-2552 16 p.

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  18 Citations (Scopus)

• Discovery of the first genome-wide significant risk loci for syncope and collapse: [Meeting Abstract]

  Ahlberg, G., Hadji-Turdeghal, K., Andreasen, L., Hagen, C. M., Ghouse, J., Baekvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Hedley, P., Haunsoe, S., Svendsen, J. H., Jepps, T. A., Skov, M. W., Christiansen, M. & Olesen, M. S., 2019, In: European Heart Journal. 40, S1, p. 2539-2539 4259 .

  Research output: Contribution to journal › Conference abstract in journal › Research

• Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice

  Hu, Z., Jepps, T. A., Zhou, L., Liu, J., Li, M. & Abbott, G. W., 1 May 2019, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 316, 5, p. R552-R562

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines

  Manville, R. W., van der Horst, J., Redford, K. E., Katz, B. B., Jepps, T. A. & Abbott, G. W., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 42, p. 21236-21245

  Research output: Contribution to journal › Journal article › Research › peer-review

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  36 Citations (Scopus)

• TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension

  Askew Page, H. R., Dalsgaard, T., Baldwin, S. N., Jepps, T. A., Povstyan, O., Olesen, S. P. & Greenwood, I. A., Jun 2019, In: British Journal of Pharmacology. 176, 11, p. 1635-1648

  Research output: Contribution to journal › Journal article › Research › peer-review

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  32 Citations (Scopus)
• 2018

  4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances K7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries

  Khammy, M. M., Kim, S., Bentzen, B. H., Lee, S., Choi, I., Aalkjaer, C. & Jepps, T. A., Feb 2018, In: British Journal of Pharmacology. 175, 3, p. 501-516 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  23 Citations (Scopus)

• Angiotensin II Promotes K_V7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90)

  Barrese, V., Stott, J. B., Figueiredo, H. B., Aubdool, A. A., Hobbs, A. J., Jepps, T. A., McNeish, A. J. & Greenwood, I. A., Jun 2018, In: Hypertension. 71, 6, p. 1091-1100 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Contractile responses in intact and mucosa-denuded human ureter: a comparison with urinary bladder detrusor preparations

  Roedel, M., Ravens, U., Kasper, M., Wirth, M. P., Jepps, T. A. & Propping, S., 1 Aug 2018, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 391, 8, p. 773-782 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Impaired Kv7 channel function in cerebral arteries of a tauopathy mouse model (rTg4510)

  de Jong, I. E. M. & Jepps, T. A., Dec 2018, In: Physiological Reports. 6, 23, 10 p., e13920 .

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

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• Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth Muscle

  Lindman, J., Khammy, M. M., Lundegaard, P. R., Aalkjær, C. & Jepps, T. A., Feb 2018, In: Hypertension. 71, 2, p. 336-345 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)
• 2017

  Unravelling the complexities of vascular smooth muscle ion channels: Fine tuning of activity by ancillary subunits

  Jepps, T. A., Oct 2017, In: Pharmacology & Therapeutics. 178, p. 57-66 10 p.

  Research output: Contribution to journal › Review › Research › peer-review
  8 Citations (Scopus)
• 2016

  Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity

  Abbott, G. W. & Jepps, T. A., 7 Oct 2016, In: Journal of Vascular Research. 53, 3-4, p. 138-148 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension

  Carr, G., Barrese, V., Stott, J. B., Povstyan, O. V., Jepps, T. A., Figueiredo, H. B., Zheng, D., Jamshidi, Y. & Greenwood, I. A., 7 Jul 2016, In: Cardiovascular Research. 112, p. 581-589 9 p.

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  44 Citations (Scopus)

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• Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats

  Jepps, T. A., Olesen, S. P., Greenwood, I. A. & Dalsgaard, T., May 2016, In: British Journal of Pharmacology. 173, 9, p. 1478-1490 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts

  Skarsfeldt, M. A., Jepps, T. A., Bomholtz, S. H., Abildgaard, L., Sørensen, U. S., Gregers, E., Svendsen, J. H., Diness, J. G., Grunnet, M., Schmitt, N., Olesen, S-P. & Bentzen, B. H., Apr 2016, In: Pfluegers Archiv. 468, 4, p. 643-654 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2015

  Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats

  Stott, J. B., Barrese, V., Jepps, T. A., Leighton, E. V. & Greenwood, I. A., Mar 2015, In: Hypertension. 65, 3, p. 676-82 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  52 Citations (Scopus)

• Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone

  Jepps, T. A., Carr, G., Lundegaard, P. R., Olesen, S-P. & Greenwood, I. A., 15 Dec 2015, In: Journal of Physiology. 593, 24, p. 5325-40 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  62 Citations (Scopus)
• 2014

  Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity

  Chadha, P. S., Jepps, T. A., Carr, G., Stott, J. B., Zhu, H-L., Cole, W. C. & Greenwood, I. A., Apr 2014, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 4, p. 887-93 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  75 Citations (Scopus)

• KV7 potassium channels: a new therapeutic target in smooth muscle disorders

  Stott, J. B., Jepps, T. A. & Greenwood, I. A., 12 Dec 2014, In: Drug Discovery Today. 19, 4, p. 413-424 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  83 Citations (Scopus)

• Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370

  Jepps, T. A., Bentzen, B. H., Stott, J. B., Povstyan, O. V., Sivaloganathan, K., Dalby-Brown, W. & Greenwood, I. A., 9 Jun 2014, In: British Journal of Pharmacology. 171, 19, p. 4413-4424 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)
• 2013

  Contribution of KV7 Channels to Basal Coronary Flow and Active Response to Ischemia

  Khanamiri, S., Soltysinska, E., Jepps, T. A., Bentzen, B. H., Chadha, P. S., Schmitt, N., Greenwood, I. A. & Olesen, S-P., 30 Sep 2013, In: Hypertension. 62, 6, p. 1090-1097 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  73 Citations (Scopus)

• One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders

  Jepps, T. A., Olesen, S. P. & Greenwood, I. A., 2013, In: British Journal of Pharmacology. 168, 1, p. 19-27 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)
• 2012

  Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries

  Chadha, P. S., Zunke, F., Davis, A. J., Jepps, T. A., Linders, J. T. M., Schwake, M., Towart, R. & Greenwood, I. A., Jun 2012, In: British Journal of Pharmacology. 166, 4, p. 1377-87 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)

• Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired ß-adrenoceptor-mediated relaxation of renal arteries in hypertension

  Chadha, P. S., Zunke, F., Zhu, H-L., Davis, A. J., Jepps, T. A., Olesen, S-P., Cole, W. C., Moffatt, J. D. & Greenwood, I., 2012, In: Hypertension. 59, 4, p. 877-84 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  96 Citations (Scopus)
• 2011

  Downregulation of Kv7.4 channel activity in primary and secondary hypertension

  Jepps, T. A., Chadha, P. S., Davis, A. J., Harhun, M. I., Cockerill, G. W., Olesen, S. P., Hansen, R. S. & Greenwood, I. A., 2 Aug 2011, In: Circulation. 124, 5, p. 602-11 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  127 Citations (Scopus)