Thomas Eiland Nielsen

2024

High efficacytreatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilmcompound Disperazol in combination with ciprofloxacin

Hultqvist, L. D., Andersen, J. B., Nilsson, C. M., Jansen, C. U., Rybtke, M., Jakobsen, T. H., Nielsen, T. E., Qvortrup, K., Moser, C., Graz, M., Qvortrup, K., Tolker-Nielsen, T. & Givskov, M., 2024, In: Antimicrobial Agents and Chemotherapy. 68, 6, 16 p., e01481-23.

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1 Citation (Scopus)

2022

Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

Flagstad, T., Pedersen, M. T., Jakobsen, T. H., Felding, J., Tolker-Nielsen, T., Givskov, M., Qvortrup, K. & Nielsen, T. E., 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

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2 Citations (Scopus)

26 Downloads (Pure)

2021

Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Andersen, J. B., Hultqvist, L. D., Jansen, C. U., Jakobsen, T. H., Nilsson, M., Rybtke, M., Uhd, J., Fritz, B. G., Seifert, R., Berthelsen, J., Nielsen, T. E., Qvortrup, K., Givskov, M. & Tolker-Nielsen, T., 2021, In: npj Biofilms and Microbiomes. 7, 13 p., 59.

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45 Citations (Scopus)

49 Downloads (Pure)

SAR study of 4-arylazo-3,5-diamino-1: H -pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

Jansen, C. U., Uhd, J., Andersen, J. B., Hultqvist, L. D., Jakobsen, T. H., Nilsson, M., Nielsen, T. E., Givskov, M., Tolker-Nielsen, T. & Qvortrup, K. M., 2021, In: RSC Medicinal Chemistry. 12, 11, p. 1868-1878 11 p.

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7 Citations (Scopus)

2019

Generation of a Heteropolycyclic and sp³-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence

Flagstad, T., Azevedo, C. M. G., Troelsen, N. S., Min, G. K., Macé, Y., Willaume, A., Guilleux, R., Velay, M., Bonnet, K., Morgentin, R., Nielsen, T. E. & Clausen, M. H., 2019, In: European Journal of Organic Chemistry. 2019, 5, p. 1061-1076

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7 Citations (Scopus)

19 Downloads (Pure)

Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Fong, J., Mortensen, K. T., Nørskov, A., Qvortrup, K., Yang, L., Tan, C. H., Nielsen, T. E. & Givskov, M., 2019, In: Frontiers in Cellular and Infection Microbiology. 11, 11 p., 433.

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54 Citations (Scopus)

117 Downloads (Pure)

2018

Bead-based screening in chemical biology and drug discovery

Komnatnyy, V. V., Nielsen, T. E. & Qvortrup, K., 2018, In: Chemical Communications. 54, 50, p. 6759-6771 13 p.

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29 Citations (Scopus)

Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa

Fong, J., Zhang, C., Yang, R., Boo, Z. Z., Tan, S. K., Nielsen, T. E., Givskov, M., Liu, X-W., Bin, W., Su, H. & Yang, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 1155.

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69 Citations (Scopus)

195 Downloads (Pure)

Oxidative Modification of Tryptophan-Containing Peptides

Petersen, J., Christensen, K. E., Nielsen, M. T., Mortensen, K. T., Komnatnyy, V. V., Nielsen, T. E. & Qvortrup, K., 2018, In: ACS Combinatorial Science. 20, 6, p. 344-349 6 p.

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12 Citations (Scopus)

Petasis/Diels–Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production

Flagstad, T., Azevedo, C. M. G., Min, G., Willaume, A., Morgentin, R., Nielsen, T. E. & Clausen, M. H., 2018, In: European Journal of Organic Chemistry. 2018, 36, p. 5023-5029 7 p.

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8 Citations (Scopus)

Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds

Wu, P. & Nielsen, T. E., 2018, In: Drug Discovery Today: Technologies. 29, p. 27-33

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15 Citations (Scopus)

Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

Yuan, M., Chua, S. L., Liu, Y., Drautz-Moses, D. I., Hoong Yam, J. K., Aung, T. T., Beuerman, R. W., Santillan Salido, M. M., Schuster, S. C., Tan, C. H., Givskov, M., Yang, L. & Nielsen, T. E., 2018, In: Beilstein Journal of Organic Chemistry. 14, p. 3059-3069 11 p.

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25 Citations (Scopus)

118 Downloads (Pure)

2017

A broad range quorum sensing inhibitor working through sRNA inhibition

Jakobsen, T. H., Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, M., Andersen, J. B., Petersen, R., Andersen, P. S., Nielsen, T. E., Tolker-Nielsen, T., Filloux, A., Ingmer, H. & Givskov, M., 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

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57 Citations (Scopus)

242 Downloads (Pure)

A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, M., Qvortrup, K. & Nielsen, T. E., Oct 2017, In: ACS Combinatorial Science. 19, 10, p. 657-669 13 p.

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7 Citations (Scopus)

Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists

Palmer, D., Gonçalves, J. P. L., Hansen, L. V., Wu, B., Hald, H., Schoffelen, S., Diness, F., Le Quement, S. T., Nielsen, T. E. & Meldal, M., 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 8716-8730 15 p.

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20 Citations (Scopus)

Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions

Ishoey, M., Petersen, R. G., Petersen, M. A., Wu, P., Clausen, M. H. & Nielsen, T. E., 2017, In: Chemical Communications. 53, 68, p. 9410-9413

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11 Citations (Scopus)

106 Downloads (Pure)

Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Fong, J., Yuan, M., Jakobsen, T. H., Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, T. E. & Givskov, M., 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

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88 Citations (Scopus)

2016

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

Groizeleau, J., Rybtke, M., Andersen, J. B., Berthelsen, J., Liu, Y., Yang, L., Nielsen, T. E., Kaever, V., Givskov, M. & Tolker-Nielsen, T., 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.

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20 Citations (Scopus)

2015

In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation

Chua, S. L., Hultqvist, L. D., Yuan, M., Rybtke, M., Nielsen, T. E., Givskov, M., Tolker-Nielsen, T. & Yang, L., Aug 2015, In: Nature Protocols (Print). 10, 8, p. 1165-80 16 p.

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55 Citations (Scopus)

2014

Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics

Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, M. & Nielsen, T. E., 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.

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3 Citations (Scopus)

2013

Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database

Tan, S. Y. Y., Chua, S. L., Chen, Y., Rice, S. A., Kjelleberg, S., Nielsen, T. E., Yang, L. & Givskov, M., Nov 2013, In: Antimicrobial Agents and Chemotherapy. 57, 11, p. 5629-5641 13 p.

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96 Citations (Scopus)

2011

A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins

Nandurkar, N. S., Petersen, R., Qvortrup, K., Komnatnyy, V. V., Taveras, K. M., Le Quement, S. T., Frauenlob, R., Givskov, M. & Nielsen, T. E., 28 Dec 2011, In: Tetrahedron Letters. 52, 52, p. 7121-7124 4 p.

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10 Citations (Scopus)

Thomas Eiland Nielsen

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