Thomas Elbenhardt Jensen

Search results

• 2019

  The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training: [The original title and the article is written in Persian!]

  Baghersad Renani, L., Ravasi, A. A., Shabkhiz, F. & Jensen, T. E., 2019, In: Iranian Journal of Endocrinology and Metabolism. 20, 5, p. 263-272 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  38 Downloads (Pure)
• 2018

  Lactate administration activates the ERK1/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse

  Cerda-Kohler, H., Henríquez Olguín, C. F., Casas, M., Jensen, T. E., Llanos, P. & Jaimovich, E., Sept 2018, In: Physiological Reports. 6, 18, 9 p., e13800.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  47 Citations (Scopus)

  167 Downloads (Pure)

• Low- and high-protein diets do not alter ex vivo insulin action in skeletal muscle

  Li, Z., Rasmussen, M. L., Li, J., Olguín, C. H., Knudsen, J. R., Søgaard, O., Madsen, A. L. B. & Jensen, T. E., Jul 2018, In: Physiological Reports. 6, 13, 12 p., e13798.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  6 Citations (Scopus)

  214 Downloads (Pure)

• Periodized low protein-high carbohydrate diet confers potent, but transient, metabolic improvements

  Li, Z., Rasmussen, M. L., Li, J., Henriquez-Olguin, C., Knudsen, J. R., Madsen, A. B., Sanchez-Quant, E., Kleinert, M. & Jensen, T. E., 2018, In: Molecular Metabolism. 17, p. 112-121 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

  181 Downloads (Pure)

• Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

  Kleinert, M., Parker, B. L., Jensen, T. E., Raun, S. H., Pham, P., Han, X., James, D. E., Richter, E. A. & Sylow, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 10723.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  35 Citations (Scopus)

  281 Downloads (Pure)

• Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt

  Raun, S. H., Ali, M. S., Kjøbsted, R., Møller, L. L. V., Federspiel, M. A., Richter, E. A., Jensen, T. E. & Sylow, L., 15 Jun 2018, In: Journal of Physiology. 596, 12, p. 2283-2299 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  39 Citations (Scopus)

• β-actin shows limited mobility and is only required for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle

  Madsen, A. L. B., Knudsen, J. R., Henriquez-Olguin, C., Angin, Y., Zaal, K. J., Sylow, L., Schjerling, P., Ralston, E. & Jensen, T. E., Jul 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E110-E125 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  18 Citations (Scopus)
• 2017

  Exercise-stimulated glucose uptake - regulation and implications for glycaemic control

  Sylow, L., Kleinert, M., Richter, E. A. & Jensen, T. E., 2017, In: Nature Reviews Endocrinology. 13, 3, p. 133-148 16 p.

  Research output: Contribution to journal › Review › peer-review
  340 Citations (Scopus)

• Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

  Kleinert, M., Parker, B. L., Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M. A., James, D. E. & Richter, E. A., 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)

• Rac1 and AMPK account for the majority of muscle glucose uptake stimulated by ex vivo contraction but not in vivo exercise

  Sylow, L., Møller, L. L. V., Kleinert, M., D'Hulst, G., De Groote, E., Schjerling, P., Steinberg, G. R., Jensen, T. E. & Richter, E. A., 2017, In: Diabetes. 66, 6, p. 1548-1559 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  46 Citations (Scopus)
• 2016

  Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

  Bultot, L., Jensen, T. E., Lai, Y.-C., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, E. A. & Sakamoto, K., 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  55 Citations (Scopus)

• Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

  Ross, F. A., Jensen, T. E. & Hardie, D. G., 2016, In: Biochemical Journal. 473, 2, p. 189-199 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  138 Citations (Scopus)

• Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

  Sylow, L., Laurent, I., Kleinert, M., Møller, L. L. V., Ploug, T., Schjerling, P., Bilan, P. J., Klip, A., Jensen, T. E. & Richter, E. A., 2016, In: Journal of Physiology. 594, 17, p. 4997-5008 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  85 Citations (Scopus)

• Rac1 in muscle is dispensable for improved insulin action after exercise in mice

  Sylow, L., Møller, L. L. V., D'Hulst, G., Schjerling, P., Jensen, T. E. & Richter, E. A., 2016, In: Endocrinology. 157, 8, p. 3009-3015 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation

  Fritzen, A. M., Madsen, A. L. B., Kleinert, M., Treebak, J. T., Lundsgaard, A., Jensen, T. E., Richter, E. A., Wojtaszewski, J., Kiens, B. & Frøsig, C., 2016, In: Journal of Physiology. 594, 3, p. 745-761 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  79 Citations (Scopus)

• Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle

  Fritzen, A. M., Frøsig, C., Jeppesen, J. F., Jensen, T. E., Lundsgaard, A., Serup, A. K. L., Schjerling, P., Proud, C. G., Richter, E. A. & Kiens, B., 2016, In: Cellular Signalling. 28, 6, p. 663-674 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  74 Citations (Scopus)

• α-MSH stimulates glucose uptake in mouse muscle and phosphorylates Rab-GTPase-activating protein TBC1D1 independently of AMPK

  Møller, C. L., Kjøbsted, R., Enriori, P. J., Jensen, T. E., Garcia-Rudaz, C., Litwak, S. A., Raun, K., Wojtaszewski, J., Wulff, B. S. & Cowley, M. A., 2016, In: P L o S One. 11, 7, 18 p., e0157027.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  307 Downloads (Pure)
• 2015

  Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise-regulated kinases and AMPK substrates

  Hoffman, N. J., Parker, B. L., Chaudhuri, R., Fisher-Wellman, K. H., Kleinert, M., Humphrey, S. J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D. J., Stöckli, J., Burchfield, J. G., Jensen, T. E., Jothi, R., Kiens, B., Wojtaszewski, J., Richter, E. A. & James, D. E., 2015, In: Cell Metabolism. 22, 5, p. 922-935 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  326 Citations (Scopus)

• PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

  Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E. A., 2015, In: Biochemical Journal. 467, 3, p. 461-472 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Reply from Lykke Sylow, Lisbeth L. V. Møller, Maximilian Kleinert, Erik A. Richter and Thomas E. Jensen

  Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. A. & Jensen, T. E., 2015, In: Journal of Physiology. 593, 9, p. 2239-2240 2 p.

  Research output: Contribution to journal › Comment/debate › Research

• Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1

  Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. A. & Jensen, T. E., 2015, In: Journal of Physiology. 593, 3, p. 645-656 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  51 Citations (Scopus)

• The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

  Chang, Y.-J., Pownall, S., Jensen, T. E., Mouaaz, S., Foltz, W., Zhou, L., Liadis, N., Woo, M., Hao, Z., Dutt, P., Bilan, P. J., Klip, A., Mak, T. & Stambolic, V., 2015, In: eLife. 4, 24 p., e06011.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  22 Citations (Scopus)

  105 Downloads (Pure)
• 2014

  Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

  Kleinert, M., Sylow, L., Fazakerley, D. J., Krycer, J. R., Thomas, K. C., Oxbøll, A.-J., Jordy, A. B., Jensen, T. E., Yang, G., Schjerling, P., Kiens, B., James, D. E., Ruegg, M. A. & Richter, E. A., 2014, In: Molecular Metabolism. 3, 6, p. 630-641 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  72 Citations (Scopus)

• Akt and Rac1 signalling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

  Sylow, L., Kleinert, M., Pehmøller, C., Prats Gavalda, C., Chiu, T. T., Klip, A., Richter, E. A. & Jensen, T. E., 2014, In: Cellular Signalling. 26, 2, p. 323-331 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  119 Citations (Scopus)

• Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca²⁺ release

  Jensen, T. E., Sylow, L., Rose, A. J., Madsen, A. L. B., Angin, Y., Maarbjerg, S. J. & Richter, E. A., 2014, In: Molecular Metabolism. 3, 7, p. 742-753 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  64 Citations (Scopus)

• Is contraction-stimulated glucose transport feedforward regulated by Ca²⁺?

  Jensen, T. E., Angin, Y., Sylow, L. & Richter, E. A., 2014, In: Experimental Physiology. 99, 12, p. 1562-1568 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans

  Fink, L. N., Costford, S. R., Lee, Y. S., Jensen, T. E., Bilan, P. J., Oberbach, A., Blüher, M., Olefsky, J. M., Sams, A. & Klip, A., 2014, In: Obesity. 22, 3, p. 747-757 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  156 Citations (Scopus)

• Rac1- a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

  Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. A. & Jensen, T. E., 2014, In: Experimental Physiology. 99, 12, p. 1574-1580 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)
• 2013

  AMPK and insulin action: Responses to ageing and high fat diet

  Frøsig, C., Jensen, T. E., Jeppesen, J., Pehmøller, C., Treebak, J. T., Maarbjerg, S. J., Kristensen, J. M., Sylow, L., Alsted, T. J., Schjerling, P., Kiens, B., Wojtaszewski, J. & Richter, E. A., 2013, In: P L o S One. 8, 5, p. e62338 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  28 Citations (Scopus)

  2087 Downloads (Pure)

• Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

  Sylow, L., Jensen, T. E., Kleinert, M., Mouatt, J. R., Maarbjerg, S. J., Jeppesen, J. F., Prats Gavalda, C., Chiu, T. T., Boguslavsky, S., Klip, A., Schjerling, P. & Richter, E. A., 2013, In: Diabetes. 62, 4, p. 1139-1151 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  119 Citations (Scopus)

• Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle

  Sylow, L., Jensen, T. E., Kleinert, M., Højlund, K., Kiens, B., Wojtaszewski, J., Prats Gavalda, C., Schjerling, P. & Richter, E. A., 2013, In: Diabetes. 62, 6, p. 1865-1875 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  153 Citations (Scopus)
• 2012

  5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

  Stride, N., Larsen, S., Treebak, J. T., Hansen, C. N., Hey-Mogensen, M., Speerschneider, T., Jensen, T. E., Jeppesen, J., Wojtaszewski, J., Richter, E., Køber, L. & Dela, F., 22 Feb 2012, In: Frontiers in Physiology. 3, 7 p., 00033.

  Research output: Contribution to journal › Journal article › Research › peer-review

• EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle

  Jensen, T. E., Leutert, R., Rasmussen, S. T., Mouatt, J. R., Christiansen, M. L. B., Jensen, B. R. & Richter, E. A., 2012, In: P L o S One. 7, 2, p. e31054 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Regulation of glucose and glycogen metabolism during and after exercise

  Jensen, T. E. & Richter, E. A., 2012, In: Journal of Physiology. 590, 5, p. 1069-1076 8 p.

  Research output: Contribution to journal › Review › peer-review
  196 Citations (Scopus)

• TLR2 controls intestinal carcinogen detoxication by CYP1A1

  Do, K. N., Fink, L. N., Jensen, T. E., Gautier, L. & Parlesak, A., 2012, In: P L o S One. 7, 3, 7 p., e32309.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)
• 2011

  Lipid induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling

  Høeg, L. D., Sjøberg, K. A., Jeppesen, J., Jensen, T. E., Frøsig, C., Birk, J. B., Bisiani, B., Hiscock, N., Pilegaard, H., Wojtaszewski, J., Richter, E. A. & Kiens, B., 2011, In: Diabetes. 60, 1, p. 64-73 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  103 Citations (Scopus)

• Protein kinase C {alpha} activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle

  Thomassen, M., Rose, A. J., Jensen, T. E., Maarbjerg, S. J., Bune, L. T., Leitges, M., Richter, E. A., Bangsbo, J. & Nordsborg, N. B., 2011, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 301, 6, p. R1808-R1814 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

  Chiu, T. T., Jensen, T. E., Sylow, L., Richter, E. A. & Klip, A., 2011, In: Cellular Signalling. 23, 10, p. 1546-1554 9 p.

  Research output: Contribution to journal › Review › peer-review
  120 Citations (Scopus)

• Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes

  Gormand, A., Henriksson, E., Ström, K., Jensen, T. E., Sakamoto, K. & Göransson, O., 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  70 Citations (Scopus)

• When less is more: a simple Western blotting amendment allowing data acquisition on human single fibers

  Jensen, T. E. & Richter, E. A., 2011, In: Journal of Applied Physiology. 110, 3, p. 583-584 2 p.

  Research output: Contribution to journal › Editorial › Research
  1 Citation (Scopus)
• 2010

  AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids

  Jelenik, T., Rossmeisl, M., Kuda, O., Jilkova, Z. M., Medrikova, D., Kus, V., Hensler, M., Janovska, P., Miksik, I., Baranowski, M., Gorski, J., Hébrard, S., Jensen, T. E., Flachs, P., Hawley, S., Viollet, B. & Kopecky, J., 2010, In: Diabetes. 59, 11, p. 2737-2746 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  77 Citations (Scopus)
• 2009

  A Ca²⁺-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions

  Rose, A. J., Alsted, T. J., Jensen, T. E., Kobberø, J. B., Maarbjerg, S. J., Jensen, J. & Richter, E. A., 2009, In: Journal of Physiology. 587, 7, p. 1547-1563 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  91 Citations (Scopus)

• AMP-activated protein kinase in contraction regulation of skeletal muscle metabolism: necessary and/or sufficient?

  Jensen, T. E., Wojtaszewski, J. & Richter, E. A., 2009, In: Acta Physiologica (Print Edition). 196, 1, p. 155-174 20 p.

  Research output: Contribution to journal › Review › peer-review
  63 Citations (Scopus)

• Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes

  Habets, D. D. J., Coumans, W. A., El Hasnaoui, M., Zarrinpashneh, E., Bertrand, L., Viollet, B., Kiens, B., Jensen, T. E., Richter, E. A., Bonen, A., Glatz, J. F. C. & Luiken, J. J. F. P., 2009, In: BBA General Subjects. 1791, 3, p. 212-219 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  85 Citations (Scopus)

• Genetic impairment of AMPK{alpha}2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice

  Maarbjerg, S. J., Jørgensen, S. B., Rose, A. J., Jeppesen, J., Jensen, T. E., Treebak, J. T., Birk, J. B., Schjerling, P., Wojtaszewski, J. & Richter, E. A., 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 4, p. E924-E934 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  74 Citations (Scopus)

• Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake

  Jensen, T. E., Maarbjerg, S. J., Rose, A. J., Leitges, M. & Richter, E. A., 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 2, p. E340-E348 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle

  Murgia, M., Elbenhardt Jensen, T., Cusinato, M., Garcia, M., Richter, E. A. & Schiaffino, S., 2009, In: Journal of Physiology. 587, 17, p. 4319-4327 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)
• 2008

  AMPK alpha₁ activation is required for stimulation of glucose uptake by twitch contraction, but not by H₂O₂, in mouse skeletal muscle

  Jensen, T. E., Schjerling, P., Viollet, B., Wojtaszewski, J. & Richter, E. A., 2008, In: PLoS ONE. 3, 5, 9 p., e2102.

  Research output: Contribution to journal › Journal article › Research › peer-review
  75 Citations (Scopus)

• Importance of candidate signalling proteins to contraction-stimulated glucose uptake

  Jensen, T. E., 2008, Copenhagen: Department of Exercise and Sport Sciences, University of Copenhagen. 170 p.

  Research output: Book/Report › Ph.D. thesis
• 2007

  Caffeine-induced Ca²⁺ release increases AMPK-dependent glucose uptake in rodent soleus muscle

  Jensen, T. E., Rose, A. J., Hellsten, Y., Wojtaszewski, J. & Richter, E. A., 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 1, p. E286-E292 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  128 Citations (Scopus)