Thomas Mandel Clausen

Research output

Research output per year 2012 2016 2020 2021 2024

• 2110 Citations
• 29 Journal article
• 1 Review

Research output per year

Research output per year

Search results

• 2024

  CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches

  Tang, J., Zheng, Q., Wang, Q., Zhao, Y., Ananthanarayanan, P., Reina, C., Šabanović, B., Jiang, K., Yang, M-H., Meny, C. C., Wang, H., Agerbaek, M. Ø., Clausen, T. M., Gustavsson, T., Wen, C., Borghi, F., Mellano, A., Fenocchio, E., Gregorc, V., Sapino, A. & 6 others, Theander, T. G., Fu, D., Aicher, A., Salanti, A., Shen, B. & Heeschen, C., 2024, In: Cell Reports Medicine. 5, 9, 26 p., 101692.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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• Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate

  Vidal-Calvo, E. E., Martin-Salazar, A., Choudhary, S., Dagil, R., Raghavan, S. S. R., Duvnjak, L., Nordmaj, M. A., Clausen, T. M., Skafte, A., Oberkofler, J., Wang, K., Agerbæk, M. Ø., Løppke, C., Jørgensen, A. M., Ropac, D., Mujollari, J., Willis, S., Garcias López, A., Miller, R. L., Karlsson, R. T. G. & 21 others, Goerdeler, F., Chen, Y-H., Colaço, A. R., Wang, Y., Lavstsen, T., Martowicz, A., Nelepcu, I., Marzban, M., Oo, H. Z., Ørum-Madsen, M. S., Wang, Y., Nielsen, M. A., Clausen, H., Wierer, M., Wolf, D., Gögenur, I., Theander, T. G., Al-Nakouzi, N., Gustavsson, T., Daugaard, M. & Salanti, A., 2024, In: Nature Communications. 15, 1, 20 p., 7553.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

  13 Downloads (Pure)
• 2023

  Identification of global inhibitors of cellular glycosylation

  Sørensen, D. M., Büll, C., Madsen, T. D., Lira-Navarrete, E., Clausen, T. M., Clark, A. E., Garretson, A. F., Karlsson, R., Pijnenborg, J. F. A., Yin, X., Miller, R. L., Chanda, S. K., Boltje, T. J., Schjoldager, K. T., Vakhrushev, S. Y., Halim, A., Esko, J. D., Carlin, A. F., Hurtado-Guerrero, R., Weigert, R. & 2 others, Clausen, H. & Narimatsu, Y., 2023, In: Nature Communications. 14, 1, 19 p., 948.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  10 Citations (Scopus)

  22 Downloads (Pure)
• 2022

  Noninvasive detection of any-stage cancer using free glycosaminoglycans

  Bratulic, S., Limeta, A., Dabestani, S., Birgisson, H., Enblad, G., Stålberg, K., Hesselager, G., Häggman, M., Höglund, M., Simonson, O. E., Stålberg, P., Lindman, H., Bång-Rudenstam, A., Ekstrand, M., Kumar, G., Cavarretta, I., Alfano, M., Pellegrino, F., Mandel-Clausen, T., Salanti, A. & 16 others, Maccari, F., Galeotti, F., Volpi, N., Daugaard, M., Belting, M., Lundstam, S., Stierner, U., Nyman, J., Bergman, B., Edqvist, P-H., Levin, M., Salonia, A., Kjölhede, H., Jonasch, E., Nielsen, J. & Gatto, F., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 50, p. e2115328119

  Research output: Contribution to journal › Journal article › Research › peer-review

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  32 Citations (Scopus)

  24 Downloads (Pure)

• Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer

  Al Nakouzi, N., Wang, C. K., Oo, H. Z., Nelepcu, I., Lallous, N., Spliid, C. B., Khazamipour, N., Lo, J., Truong, S., Collins, C., Hui, D., Esfandnia, S., Adomat, H., Clausen, T. M., Gustavsson, T., Choudhary, S., Dagil, R., Corey, E., Wang, Y., Chauchereau, A. & 6 others, Fazli, L., Esko, J. D., Salanti, A., Nelson, P. S., Gleave, M. & Daugaard, M., 2022, In: Nature Communications. 13, 4760.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  27 Downloads (Pure)
• 2021

  Beware, commercial chondroitinases vary in activity and substrate specificity

  Spliid, C. B., Toledo, A. G., Salanti, A., Esko, J. D. & Clausen, T. M., 2021, In: Glycobiology. 31, 2, p. 103-115 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

  Yuan, S., Yin, X., Meng, X., Chan, J. F. W., Ye, Z. W., Riva, L., Pache, L., Chan, C. C. Y., Lai, P. M., Chan, C. C. S., Poon, V. K. M., Lee, A. C. Y., Matsunaga, N., Pu, Y., Yuen, C. K., Cao, J., Liang, R., Tang, K., Sheng, L., Du, Y. & 25 others, Xu, W., Lau, C. Y., Sit, K. Y., Au, W. K., Wang, R., Zhang, Y. Y., Tang, Y. D., Clausen, T. M., Pihl, J., Oh, J., Sze, K. H., Zhang, A. J., Chu, H., Kok, K. H., Wang, D., Cai, X. H., Esko, J. D., Hung, I. F. N., Li, R. A., Chen, H., Sun, H., Jin, D. Y., Sun, R., Chanda, S. K. & Yuen, K. Y., 2021, In: Nature. 593, p. 418–423

  Research output: Contribution to journal › Journal article › Research › peer-review

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  153 Citations (Scopus)

  6 Downloads (Pure)

• Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

  Wang, K., Dagil, R., Lavstsen, T., Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, T., Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, S., Agerbaek, M. Ø., Lindorff-Larsen, K., Nielsen, M. A., Theander, T. G., Sharp, J. S., Clausen, T. M., Gourdon, P. & Salanti, A., 2021, In: Nature Communications. 12, 1, 10 p., 2956.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  30 Citations (Scopus)

  103 Downloads (Pure)

• Development of a bispecific immune engager using a recombinant malaria protein

  Nordmaj, M. A., Roberts, M. E., Sachse, E. S., Dagil, R., Andersen, A. P., Skeltved, N., Grunddal, K. V., Erdoğan, S. M., Choudhary, S., Gustavsson, T., Ørum-madsen, M. S., Moskalev, I., Tian, W., Yang, Z., Clausen, T. M., Theander, T. G., Daugaard, M., Nielsen, M. A. & Salanti, A., 2021, In: Cell Death & Disease. 12, 4, 11 p., 353.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Citations (Scopus)

  59 Downloads (Pure)

• Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

  Karlsson, R., Chopra, P., Joshi, A., Yang, Z., Vakhrushev, S. Y., Clausen, T. M., Painter, C. D., Szekeres, G. P., Chen, Y. H., Sandoval, D. R., Hansen, L., Esko, J. D., Pagel, K., Dyer, D. P., Turnbull, J. E., Clausen, H., Boons, G. J. & Miller, R. L., 2021, In: Science Advances. 7, 52, eabl6026.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  29 Citations (Scopus)

  36 Downloads (Pure)

• Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

  Weiss, R. J., Spahn, P. N., Chiang, A. W. T., Liu, Q., Li, J., Hamill, K. M., Rother, S., Clausen, T. M., Hoeksema, M. A., Timm, B. M., Godula, K., Glass, C. K., Tor, Y., Gordts, P. L. S. M., Lewis, N. E. & Esko, J. D., 2021, In: Nature Chemical Biology. 17, p. 684–692

  Research output: Contribution to journal › Journal article › Research › peer-review

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  14 Citations (Scopus)

  8 Downloads (Pure)

• Oncofetal chondroitin sulfate is a highly expressed therapeutic target in non-small cell lung cancer

  Oo, H. Z., Lohinai, Z., Khazamipour, N., Lo, J., Kumar, G., Pihl, J., Adomat, H., Nabavi, N., Behmanesh, H., Zhai, B., Dagil, R., Choudhary, S., Gustavsson, T., Clausen, T. M., Esko, J. D., Allen, J. W., Thompson, M. A., Tran, N. L., Moldvay, J., Dome, B. & 4 others, Salanti, A., Al-Nakouzi, N., Weiss, G. J. & Daugaard, M., 2021, In: Cancers. 13, 17, 16 p., 4489.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  7 Citations (Scopus)

  27 Downloads (Pure)

• The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

  Spliid, C. B., Toledo, A. G., Sanderson, P., Mao, Y., Gatto, F., Gustavsson, T., Choudhary, S., Saldanha, A. L., Vogelsang, R. P., Gögenur, I., Theander, T. G., Leach, F. E., Amster, I. J., Esko, J. D., Salanti, A. & Clausen, T. M., 2021, In: The Journal of Biological Chemistry. 297, 6, 15 p., 101391.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  29 Downloads (Pure)
• 2020

  An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer

  Toledo, A. G., Pihl, J., Spliid, C. B., Persson, A., Nilsson, J., Pereira, M. A., Gustavsson, T., Choudhary, S., Zarni Oo, H., Black, P. C., Daugaard, M., Esko, J. D., Larson, G., Salanti, A. & Clausen, T. M., 2020, In: Glycobiology. 30, 12, p. 989-1002 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  18 Citations (Scopus)

• A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine

  Clausen, T. M., Kumar, G., Ibsen, E. K., Ørum-Madsen, M. S., Hurtado-Coll, A., Gustavsson, T., Agerbæk, M. Ø., Gatto, F., Todenhöfer, T., Basso, U., Knowles, M. A., Sanchez-Carbayo, M., Salanti, A., Black, P. C. & Daugaard, M., 2020, In: Cell Death Discovery. 6, 65.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  9 Citations (Scopus)

  65 Downloads (Pure)

• SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

  Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., Yang, Z., Torres, J. L., Golden, G. J., Bartels, P. L., Porell, R. N., Garretson, A. F., Laubach, L., Feldman, J. & 16 others, Yin, X., Pu, Y., Hauser, B. M., Caradonna, T. M., Kellman, B. P., Martino, C., Gordts, P. L. S. M., Chanda, S. K., Schmidt, A. G., Godula, K., Leibel, S. L., Jose, J., Corbett, K. D., Ward, A. B., Carlin, A. F. & Esko, J. D., 2020, In: Cell. 183, 4, p. 1043-1057.e15

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  807 Citations (Scopus)

• The role of proteoglycans in cancer metastasis and circulating tumor cell analysis

  Ahrens, T. D., Bang-Christensen, S. R., Jørgensen, A. M., Løppke, C., Spliid, C. B., Sand, N. T., Clausen, T. M., Salanti, A. & Agerbæk, M. O., 2020, In: Frontiers in Cell and Developmental Biology. 8, 27 p., 749.

  Research output: Contribution to journal › Review › Research › peer-review

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  57 Citations (Scopus)

  86 Downloads (Pure)
• 2019

  Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein

  Bang-Christensen, S. R., Pedersen, R. S., Pereira, M. A., Clausen, T. M., Løppke, C., Sand, N. T., Ahrens, T. D., Jørgensen, A. M., Lim, Y. C., Goksøyr, L., Choudhary, S., Gustavsson, T., Dagil, R., Daugaard, M., Sander, A. F., Torp, M. H., Søgaard, M., Theander, T. G., Østrup, O., Lassen, U. & 3 others, Hamerlik, P., Salanti, A. & Agerbæk, M. Ø., 2019, In: Cells. 8, 9, 21 p., 998.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  52 Citations (Scopus)

  128 Downloads (Pure)
• 2018

  The GAGOme: a cell-based library of displayed glycosaminoglycans

  Chen, Y-H., Narimatsu, Y., Clausen, T. M., Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, T., Salanti, A., Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, E. P., Mao, Y., Clausen, H. & Yang, Z., 2018, In: Nature Methods. 15, 11, p. 881-888

  Research output: Contribution to journal › Journal article › Research › peer-review
  107 Citations (Scopus)

• The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

  Agerbæk, M. Ø., Bang-Christensen, S. R., Yang, M-H., Clausen, T. M., Pereira, M. A., Sharma, S., Ditlev, S. B., Nielsen, M. A., Choudhary, S., Gustavsson, T., Sorensen, P. H., Meyer, T., Propper, D., Shamash, J., Theander, T. G., Aicher, A., Daugaard, M., Heeschen, C. & Salanti, A., 2018, In: Nature Communications. 9, 1, 13 p., 3279.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  118 Citations (Scopus)

  273 Downloads (Pure)

• Virus-like particle display of HER2 induces potent anti-cancer responses

  Palladini, A., Thrane, S., Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, T. M., Nicoletti, G., Landuzzi, L., Penichet, M. L., Balboni, T., Ianzano, M. L., Giusti, V., Theander, T. G., Nielsen, M. A., Salanti, A., Lollini, P-L., Nanni, P. & Sander, A. F., 2018, In: OncoImmunology. 7, 3, 12 p., e1408749.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  80 Citations (Scopus)
• 2017

  An oncofetal glycosaminoglycan modification provides therapeutic access to Cisplatin-resistant bladder cancer

  Seiler, R., Oo, H. Z., Tortora, D., Clausen, T. M., Wang, C. K., Kumar, G., Ayres Pereira, M., Ørum-Madsen, M. S., Agerbæk, M. Ø., Gustavsson, T., Nordmaj, M. A., Rich, J. R., Lallous, N., Fazli, L., Lee, S., Douglas, J., Todenhöfer, T., Esfandnia, S., Battsogt, D., Babcook, J. S. & 10 others, Al Nakouzi, N., Crabb, S. J., Moskalev, I., Kiss, B., Davicioni, E., Thalmann, G. N., Rennie, P. S., Black, P. C., Salanti, A. & Daugaard, M., 2017, In: European Urology Supplements. 72, 1, p. 142-150 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)

• Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration

  Agerbaek, M. Ø., Bento Ayres Pereira, M. M., Clausen, T. M., Pehrson, C., Oo, H. Z., Spliid, C., Rich, J. R., Fung, V., Nkrumah, F., Neequaye, J., Biggar, R. J., Reynolds, S. J., Tosato, G., Pullarkat, S. T., Ayers, L. W., Theander, T. G., Daugaard, M., Bhatia, K., Nielsen, M. A., Mbulaiteye, S. M. & 1 others, Salanti, A., 2017, In: International Journal of Cancer. 140, 7, p. 1597–1608 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  15 Citations (Scopus)
• 2016

  Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library

  Sugiura, N., Clausen, T. M., Shioiri, T., Gustavsson, T., Watanabe, H. & Salanti, A., Dec 2016, In: Glycoconjugate Journal. 33, 6, p. 985-994 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility

  Clausen, T. M., Bento Ayres Pereira, M. M., Al Nakouzi, N., Oo, H. Z., Agerbæk, M. Ø., Lee, S., Ørum-Madsen, M. S., Kristensen, A. R., El-Naggar, A., Grandgenett, P. M., Grem, J. L., Hollingsworth, M. A., Holst, P. J., Theander, T., Sorensen, P. H., Daugaard, M. & Salanti, A., Dec 2016, In: Molecular Cancer Research. 14, 12, p. 1288-1299 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  56 Citations (Scopus)

• Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1

  Ayres Pereira, M., Mandel Clausen, T., Pehrson, C., Mao, Y., Resende, M., Daugaard, M., Riis Kristensen, A., Spliid, C. B., Mathiesen, L., E Knudsen, L., Damm, P., G Theander, T., R Hansson, S., A Nielsen, M. & Salanti, A., Aug 2016, In: P L o S Pathogens. 12, 8, 26 p., e1005831.

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  78 Citations (Scopus)

  587 Downloads (Pure)

• Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting

  Clausen, T. M., Ayres Pereira, M., Oo, H. Z., Resende, M., Gustavson, T., Mao, Y., Sugiura, N., Liew, J., Fazli, L., Theander, T. G., Daugaard, M. & Salanti, A., Jul 2016, In: Sensing and Bio-Sensing Research. 9, p. 23-30 8 p.

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  17 Citations (Scopus)

  826 Downloads (Pure)
• 2015

  Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

  Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, Thrane, S., Holst, P. J., Meng, L., Favero, F., Weiss, G. J., Nielsen, M. A., Freeth, J., Nielsen, T. O., Zaia, J., Tran, N. L., Trent, J., Babcook, J. S., Theander, T. G., Sorensen, P. H. & Daugaard, M., 2015, In: Cancer Cell. 28, 4, p. 500-14 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  166 Citations (Scopus)
• 2014

  Characterization of human placental glycosaminoglycans and regional binding to VAR2CSA in malaria infected erythrocytes

  Beaudet, J. M., Mansur, L., Joo, E. J., Kamhi, E., Yang, B., Clausen, T. M., Salanti, A., Zhang, F. & Linhardt, R. J., Feb 2014, In: Glycoconjugate Journal. 31, 2, p. 109-16 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)
• 2012

  Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

  Clausen, T. M., Christoffersen, S., Dahlbäck, M., Langkilde, A. E., Jensen, K. E., Resende, M., Agerbæk, M. Ø., Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, M. A., Theander, T. G., Larsen, S. & Salanti, A., 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  146 Citations (Scopus)