Research output per year
Research output per year
MD, DMSc, specialist in internal medicine and endocrinology
Blegdamsvej 3, 2200 København N.
Blegdamsvej 3B
2200 København N
Research activity per year
Thomas Mandrup-Poulsen is a physician scientist, specialist in internal medicine and endocrinology. He is a pioneer in the field of immuno-metabolism with the discovery that inflammatory cytokines impair the function and viability of pancreatic islet b-cells [1, 2], for which he was awarded the 1994 Minkowski Prize of the EASD. His research focuses on the mechanisms of action of pro-inflammatory cytokines, metabolites and oxidative stress causing islet cell damage in diabetes and how this can be prevented, employing in silico, in vitro, ex vivo and in vivo studies, animal diabetes models and clinical trials in diabetic patients. He and colleagues conducted the first proof-of-concept clinical trial showing that pro-inflammatory cytokine antagonists improve glycemia and b-cell function in diabetic patients [3, 4]. His expertise covers basic molecular and cellular techniques in b-cell biology, stress signalling, genomics and proteomics, epigenetics, animal models, clinical intervention trials and pharmaco-genomic and biochemical biomarker studies. >370 publications e.g. in Science, Lancet, N Engl J Med, Cell Metabolism, J Clin Invest, Proc Natl Acad Sci USA, J Immunol, J Biol Chem, Diabetes and Diabetologia. Reviews and commentaries in e.g. Nature Immunology, Nature Rev Endocrinol, Nature Clin Pract Endocrinol Metab, Nature Study, British Medical Journal, Diabetes and Diabetologia. H-index 64. Citations >14,500. >70 invited international lectures. Wide collaborative network in Europe, North America and Australia. Leading PI or co-PI of EU and JDRF grants, 3 international multicenter clinical studies, Chair of the TRIGR-trial DSMB, Advisory board member in international multicenter studies.
Immuno-endocrinology and immuno-metabolism
Professor Mandrup-Poulsen is a physician scientist, board certified in internal medicine and endocrinology, who serves as Professor of Medical Research Methodology at the University of Copenhagen and adjunct professor in Immuno-diabetology at the Karolinska Institute in Stockholm. His research focuses on understanding inflammatory and oxidative beta-cell death leading to diabetes, and his discovery that proinflammatory cytokines cause beta-cell functional failure and destruction qualified him for the 1994 Oskar Minkowski prize of the European Association for the Study of Diabetes. He has been leading PI or co-PI of EU and JDRF (USA) grants, three international multicenter clinical studies and had leadership roles in the data safety monitoring board/advisory boards in two international multicenter clinical studies. His group currently consists of 10 academics.
Education
Emploment
Scientific journals, societies, awards etc.
Membership of major university committees, research councils, etc.
Current research support
Mechanisms of action of pro-inflammatory cytokines, metabolites and oxidative stress causing islet cell damage in diabetes and how this can be prevented.
Basic molecular and cellular studies in b-cell biology, stress signalling, genomics and proteomics, epigenetics, animal models, clinical intervention trials and pharmaco-genomic and biochemical biomarker studies.
Molecular biomedicine, endocrinology
Research output: Working paper › Preprint › Research
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review