Thomas Svava Nielsen

Research output

Research output per year 2010 2012 2014 2016 2019 2021 2022 2024

• 1521 Citations
• 36 Journal article
• 2 Conference abstract in journal
• 1 Letter
• 1 Review

Research output per year

Research output per year

Search results

• 2024

  NK2R control of energy expenditure and feeding to treat metabolic diseases

  Sass, F., Ma, T., Ekberg, J. H., Kirigiti, M., Ureña, M. G., Dollet, L., Brown, J. M., Basse, A. L., Yacawych, W. T., Burm, H. B., Andersen, M. K., Nielsen, T. S., Tomlinson, A. J., Dmytiyeva, O., Christensen, D. P., Bader, L., Vo, C. T., Wang, Y., Rausch, D. M., Kristensen, C. K. & 27 others, Gestal-Mato, M., In het Panhuis, W., Sjøberg, K. A., Kernodle, S., Petersen, J. E., Pavlovskyi, A., Sandhu, M., Moltke, I., Jørgensen, M. E., Albrechtsen, A., Grarup, N., Babu, M. M., Rensen, P. C. N., Kooijman, S., Seeley, R. J., Worthmann, A., Heeren, J., Pers, T. H., Hansen, T., Gustafsson, M. B. F., Tang-Christensen, M., Kilpeläinen, T. O., Myers, M. G., Kievit, P., Schwartz, T. W., Hansen, J. B. & Gerhart-Hines, Z., 2024, In: Nature. 635, 8040, p. 987–1000 37 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)
• 2023

  NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner

  Basse, A. L., Nielsen, K. N., Karavaeva, I., Ingerslev, L. R., Ma, T., Havelund, J. F., Nielsen, T. S., Frost, M., Peics, J., Dalbram, E., Dall, M., Zierath, J. R., Barrès, R., Færgeman, N. J., Treebak, J. T. & Gerhart-Hines, Z., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2220102120.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  11 Citations (Scopus)

  65 Downloads (Pure)

• Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

  Peluso, A. A., Lundgaard, A. T., Babaei, P., Mousovich-Neto, F., Rocha, A. L., Damgaard, M. V., Bak, E. G., Gnanasekaran, T., Dollerup, O. L., Trammell, S. A. J., Nielsen, T. S., Kern, T., Abild, C. B., Sulek, K., Ma, T., Gerhart-Hines, Z., Gillum, M. P., Arumugam, M., Ørskov, C., McCloskey, D. & 4 others, Jessen, N., Herrgård, M. J., Mori, M. A. S. & Treebak, J. T., 2023, In: npj Aging. 9, 21 p., 7.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  9 Citations (Scopus)

  38 Downloads (Pure)
• 2022

  Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice

  Tozzi, M., Brown, E. L., Petersen, P. SS., Lundh, M., Isidor, M. S., Plucińska, K., Nielsen, T. S., Agueda‐Oyarzabal, M., Small, L., Treebak, J. T. & Emanuelli, B., 2022, In: The Journal of Physiology. 600, 4, p. 885-902

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Citations (Scopus)

  41 Downloads (Pure)

• From trainee to trainer: lessons Learned through implementation of a dual-catheter model in mice

  Nielsen, T. S. & Treebak, J. T., 2022, In: Laboratory Animals. 56, S1, p. 105 1 p., S5C1.2.

  Research output: Contribution to journal › Conference abstract in journal › Research

  File

• Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD⁺ without impacting respiratory capacity or insulin sensitivity

  Damgaard, M. V., Nielsen, T. S., Basse, A. L., Chubanava, S., Trost, K., Moritz, T., Dellinger, R. W., Larsen, S. & Treebak, J. T., 2022, In: iScience. 25, 2, 21 p., 103863.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

  51 Downloads (Pure)

• Laboratory animal surgery, can we do better?

  Gantenbein, F., Nielsen, T. S., Hankenson, F. C., Cesarovic, N., Bollen, P. & Bouard, D., 2022, In: Laboratory Animals. 56, Suppl. 1, p. 104-105 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research

  Open Access

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  39 Downloads (Pure)
• 2021

  Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

  Lubberding, A. F., Zhang, J., Lundh, M., Nielsen, T. S., Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, M. B., Treebak, J. T., Holst, J. J., Kanters, J. K., Mandrup-Poulsen, T., Jespersen, T., Emanuelli, B. & Torekov, S. S., 2021, In: Scientific Reports. 11, 1, 14 p., 12253.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  11 Citations (Scopus)

  55 Downloads (Pure)

• An abundant biliary fatty acid metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides

  Grevengoed, T. J., Trammell, S. A. J., Svenningsen, J. S., Makarov, M., Nielsen, T. S., Jacobsen, J. C. B., Calder, P. C., Migaud, M. E., Cravatt, B. & Gillum, M. P., 2021, In: Journal of Clinical Investigation. 131, 6, 12 p., e143861.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  18 Citations (Scopus)

  96 Downloads (Pure)

• Discovery of thymosin β4 as a human exerkine and growth factor

  Gonzalez-Franquesa, A., Stocks, B., Borg, M. L., Kuefner, M., Dalbram, E., Nielsen, T. S., Agrawal, A., Pankratova, S., Chibalin, A. V., Karlsson, H. K. R., Gheibi, S., Björnholm, M., Jørgensen, N. R., Clemmensen, C., Treebak, J. T., Hostrup, M., Krook, A., Zierath, J. R. & Deshmukh, A. S., 2021, In: American Journal of Physiology: Cell Physiology. 321, 5, p. C770-C778 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  14 Citations (Scopus)

  56 Downloads (Pure)

• Hepatocyte-specific perturbation of NAD⁺ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes

  Dall, M., Hassing, A. S., Niu, L., Nielsen, T. S., Ingerslev, L. R., Sulek, K., Trammell, S. A. J., Gillum, M. P., Barrès, R., Larsen, S., Poulsen, S. S., Mann, M., Ørskov, C. & Treebak, J. T., 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  24 Citations (Scopus)

  25 Downloads (Pure)

• Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

  Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, M. S., Broholm, C., Pedersen, O., Hansen, J. B., Grarup, N., Hansen, T., Kjær, A., Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, J. T., Schwartz, T. W., Emanuelli, B., Bartolomucci, A., Pfeifer, A., Zechner, R., Scheele, C., Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  71 Citations (Scopus)

  93 Downloads (Pure)
• 2020

  Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

  Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., Branquinho, J. L., Razolli, D., Pinto, S., Nielsen, T. S., Festuccia, W. T., Martins, A. S., Guerra, B. A., Knittel, T. L., Søgaard, D., Larsen, S., Helge, J. W., Brandauer, J., Velloso, L. A., Emanuelli, B. & 6 others, Kornfeld, J-W., Kahn, C. R., Vienberg, S. G., Zierath, J. R., Treebak, J. T. & Mori, M. A., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 38, p. 23932-23941

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  24 Citations (Scopus)
• 2019

  Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle

  de Guia, R. M., Agerholm, M., Nielsen, T. S., Consitt, L. A., Sogaard, D., Helge, J. W., Larsen, S., Brandauer, J., Houmard, J. A. & Treebak, J. T., 2019, In: Physiological Reports. 7, 12, 15 p., e14139.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  70 Citations (Scopus)

  225 Downloads (Pure)

• Assessment of mouse liver [1-¹³C]pyruvate metabolism by dynamic hyperpolarized MRS

  Faarkrog Høyer, K., Laustsen, C., Ringgaard, S., Qi, H., Mariager, C. Ø., Nielsen, T. S., Sundekilde, U. K., Treebak, J. T., Jessen, N. & Stødkilde-Jørgensen, H., 2019, In: Journal of Endocrinology. 242, 3, p. 251-260 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans

  Ramshanker, N., Jessen, N., Voss, T. S., Pedersen, S. B., Jørgensen, J. O. L., Nielsen, T. S., Frystyk, J. & Møller, N., 2019, In: Metabolism: Clinical and Experimental. 99, p. 1-10

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals

  Park, S., Turner, K. D., Zheng, D., Brault, J. J., Zou, K., Chaves, A. B., Nielsen, T. S., Tanner, C. J., Treebak, J. T. & Houmard, J. A., 2019, In: The Journal of Physiology. 597, 2, p. 449-466

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  25 Citations (Scopus)

• Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes

  Sharma, V. M., Vestergaard, E. T., Jessen, N., Kolind-Thomsen, P., Nellemann, B., Nielsen, T. S., Vendelbo, M. H., Møller, N., Sharma, R., Lee, K. Y., Kopchick, J. J., Jørgensen, J. O. L. & Puri, V., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 1, p. E34-E42

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  43 Citations (Scopus)

• Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis

  Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, T. S., Johannsen, M., Svart, M. V., Jessen, N. & Møller, N., 2019, In: Diabetologia. 62, 3, p. 494-503

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 2018

  Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo

  Høyer, K. F., Nielsen, T. S., Risis, S., Treebak, J. T. & Jessen, N., 2018, In: Basic & Clinical Pharmacology & Toxicology. 123, 6, p. 732-738

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

  Shi, H., Munk, A., Nielsen, T. S., Daughtry, M. R., Larsson, L., Li, S., Høyer, K. F., Geisler, H. W., Sulek, K., Kjøbsted, R., Fisher, T., Andersen, M. M., Shen, Z., Hansen, U. K., England, E. M., Cheng, Z., Højlund, K., Wojtaszewski, J., Yang, X., Hulver, M. W. & 3 others, Helm, R. F., Treebak, J. T. & Gerrard, D. E., 2018, In: Molecular Metabolism. 11, p. 160-177 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  64 Citations (Scopus)

  160 Downloads (Pure)
• 2017

  Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study

  Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, T. S., Johannsen, M., Svart, M. V., Jessen, N. & Møller, N., Jan 2017, In: Diabetologia. 60, 1, p. 143-52 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)
• 2016

  Combined insulin deficiency and endotoxin exposure stimulate lipid mobilization and alter adipose tissue signaling in an experimental model of ketoacidosis in subjects with type 1 diabetes: A randomized, controlled, cross over trial

  Svart, M., Kampmann, U., Voss, T., Pedersen, S. B., Johannsen, M., Rittig, N., Poulsen, P. L., Nielsen, T. S., Jessen, N. & Møller, N., May 2016, In: Diabetes. 65, 5, p. 1380-6 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

  Jensen, B. A. H., Nielsen, T. S., Fritzen, A. M., Holm, J. B., Fjære, E., Serup, A. K. L., Borkowski, K., Risis, S., Pærregaard, S. I., Søgaard, I., Poupeau, A. A. G., Poulsen, M., Ma, T., Sina, C., Kiens, B., Madsen, L., Kristiansen, K. & Treebak, J. T., 2016, In: Metabolism. 65, 12, p. 1706-1719 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  23 Citations (Scopus)

  206 Downloads (Pure)

• Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast

  Bak, A. M., Møller, A. B., Vendelbo, M. H., Nielsen, T. S., Viggers, R., Rungby, J., Pedersen, S. B., Jørgensen, J. O. L., Jessen, N. & Møller, N., 1 Jul 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 1, p. E224-35 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• Pronounced expression of the lipolytic inhibitor G0/G1 Switch Gene 2 (G0S2) in adipose tissue from brown bears (Ursus arctos) prior to hibernation

  Jessen, N., Nielsen, T. S., Vendelbo, M. H., Viggers, R., Støen, O-G., Evans, A. & Frøbert, O., Apr 2016, In: Physiological Reports. 4, 8, p. 1-7 7 p., e12781.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  12 Citations (Scopus)

• Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial

  Rittig, N., Bach, E., Thomsen, H. H., Pedersen, S. B., Nielsen, T. S., Jørgensen, J. O., Jessen, N. & Møller, N., 2016, In: P L o S One. 11, 9, p. 1-13 13 p., e0162167.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  53 Citations (Scopus)

• Stress hormone release is a key component of the metabolic response to lipopolysaccharide (LPS): studies in hypopituitary and healthy subjects

  Bach, E., Møller, A. B., Jorgensen, J. O. L., Vendelbo, M. H., Jessen, N., Pedersen, S. B., Nielsen, T. S. & Møller, N., 25 Aug 2016, In: European Journal of Endocrinology. 175, 5, p. 455-465 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2015

  Intact Pituitary Function is Decisive for the Catabolic Response to TNF-α: Studies of Protein, Glucose and Fatty Acid Metabolism in Hypopituitary and Healthy Subjects

  Bach, E., Møller, A. B., Jørgensen, J. O. L., Vendelbo, M. H., Jessen, N., Olesen, J. F., Pedersen, S. B., Nielsen, T. S. & Møller, N., Feb 2015, In: The Journal of clinical endocrinology and metabolism. 100, 2, p. 578-86 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2014

  A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

  Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O. & 3 others, Nielsen, R., Albrechtsen, A. & Hansen, T., 2014, In: Nature. 512, 7513, p. 190-193 4 p.

  Research output: Contribution to journal › Letter › Research › peer-review
  311 Citations (Scopus)

• Adipose triglyceride lipase and g0/g1 switch gene 2: approaching proof of concept

  Nielsen, T. S. & Møller, N., Mar 2014, In: Diabetes. 63, 3, p. 847-9 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

  Nielsen, T. S., Jessen, N., Jørgensen, J. O. L., Møller, N. & Lund, S., Jun 2014, In: Journal of Molecular Endocrinology. 52, 3, p. R199-R222 24 p.

  Research output: Contribution to journal › Review › Research › peer-review
  280 Citations (Scopus)

• Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

  Nellemann, B., Vendelbo, M. H., Nielsen, T. S., Bak, A. M., Høgild, M., Pedersen, S. B., Biensø, R. S., Pilegaard, H., Møller, N., Jessen, N. & Jørgensen, J. O. L., 2014, In: Acta Physiologica. 210, 2, p. 392-402 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)
• 2012

  Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

  Christensen, B., Lundby, C., Jessen, N., Nielsen, T. S., Vestergaard, P. F., Møller, N., Pilegaard, H., Pedersen, S. B., Kopchick, J. J. & Jørgensen, J. O. L., 2012, In: P L o S One. 7, 2, 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  15 Citations (Scopus)

  762 Downloads (Pure)

• Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

  Vendelbo, M., Clasen, B. F. F., Treebak, J. T., Møller, L., Krusenstjerna-Hafstrøm, T., Madsen, M., Nielsen, T. S., Stødkilde-Jørgensen, H., Pedersen, S. B., Jørgensen, J. O. L., Goodyear, L. J., Wojtaszewski, J., Møller, N. & Jessen, N., 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 302, 2, p. E190-E200 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  56 Citations (Scopus)

• Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes

  Nielsen, T. S., Kampmann, U., Nielsen, R. R., Jessen, N., Orskov, L., Pedersen, S. B., Jørgensen, J. O. L., Lund, S. & Møller, N., Jul 2012, In: The Journal of clinical endocrinology and metabolism. 97, 7, p. E1348-52

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)
• 2011

  Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue

  Nielsen, T. S., Vendelbo, M., Jessen, N., Pedersen, S. B., Jørgensen, J. O. L., Lund, S. & Møller, N., Aug 2011, In: The Journal of clinical endocrinology and metabolism. 96, 8, p. E1293-7

  Research output: Contribution to journal › Journal article › Research › peer-review
  67 Citations (Scopus)

• GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance

  Kampmann, U., Christensen, B., Nielsen, T. S., Pedersen, S. B., Ørskov, L., Lund, S., Møller, N. & Jessen, N., 2011, In: PLOS ONE. 6, 11, p. e27854

  Research output: Contribution to journal › Journal article › Research › peer-review
  72 Citations (Scopus)
• 2010

  Effects of GH in human muscle and fat

  Jørgensen, J. O. L., Rubeck, K. Z., Nielsen, T. S., Clasen, B. F. F., Vendelboe, M., Hafstrøm, T. K., Madsen, M. & Lund, S., Apr 2010, In: Pediatric nephrology (Berlin, Germany). 25, 4, p. 705-9 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Reduced cannabinoid receptor 1 protein in subcutaneous adipose tissue of obese

  Bennetzen, M. F., Nielsen, T. S., Paulsen, S. K., Bendix, J., Fisker, S., Jessen, N., Lund, S., Richelsen, B. & Pedersen, S. B., Feb 2010, In: European Journal of Clinical Investigation. 40, 2, p. 121-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)