No photo of Thomas Werge

Thomas Werge

  • Nordre Ringvej 26-67, 2600 Glostrup

  • Blegdamsvej 3

    2200 København N.

  • Source: Scopus
20022025

Research activity per year

Personal profile

Short presentation

My research has focused on explaining the biological reasons that contributes to the development of severe mental disorders such as schizophrenia and autism - disorders, that all have great personal and social costs. In the future this knowledge provides us with the tools to diagnose patients on a patient specific level. Further it provides the basis for a personalized drug development. These can have a more directly effect on the diagnosed disease and less side effects compared to current drugs used in treatment of mental disorders. During my research I have taken initiative to create the Danish Psychiatric Biobank, which aims to identify the genetic constellations of mental disorders. Together with other international research groups I have identified changes in the genome that for some carriers can be associated with the development of severe mental disorders. On a daily basis I am PI and Co-PI on several projects that all have the purpose to obtain a thorough explanation of the biological causes of mental disorders. Such kind of work requires a broad interdisciplinary collaboration where the disorders are examined on multiple levels; from genes and cells to population cohorts, and from fetal life to the patient.

Keywords

  • Faculty of Health and Medical Sciences
  • Mental illness
  • Genetics
  • Mutations
  • Personalized drug development
  • Diagnosis
  • Schizophrenia
  • ADHD
  • Autism
  • Bipolar
  • Depression
  • Etiology
  • Genetic and environmental risk factors
  • Co-morbidity
  • Animal models

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Explore network further

  • High level of immunoglobulin G targeting mycoplasma or cytomegalovirus in the newborn increases risk of ADHD

    Borbye-Lorenzen, N., Holmgaard, S., Ottosson, F., Nudel, R., Appadurai, V., Laursen, T. M., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Nordentoft, M., Børglum, A. D., Mortensen, P. B., Werge, T., Benros, M. E., Hougaard, D. M. & Skogstrand, K., 2025, In: Brain, Behavior, and Immunity. 123, p. 99-107 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
    File

  • 100 ancient genomes show repeated population turnovers in Neolithic Denmark

    Allentoft, M. E., Sikora, M., Fischer, A., Sjögren, K-G., Ingason, A., Macleod, R., Rosengren, A., Schulz Paulsson, B., Jørkov, M. L. S., Novosolov, M., Stenderup, J., Price, T. D., Mortensen, M. F., Nielsen, A. B., Hede, M. U., Sørensen, L., Nielsen, P. O., Rasmussen, P., Jensen, T. Z. T., Refoyo-Martínez, A. & 48 others, Irving-Pease, E. K., Barrie, W., Pearson, A., Sousa da Mota, B., Demeter, F., Henriksen, R. A., Vimala, T., McColl, H., Vaughn, A., Vinner, L., Renaud, G., Stern, A., Johannsen, N. N., Ramsøe, A. D., Schork, A. J., Ruter, A., Gotfredsen, A. B., Nielsen, B. H., Petersen, E. B., Kannegaard, E., Hansen, J., Pedersen, K. B., Pedersen, L., Klassen, L., Meldgaard, M., Johansen, M., Uldum, O. C., Lotz, P., Lysdahl, P., Bangsgaard, P., Petersen, P. V., Maring, R., Iversen, R., Wåhlin, S., Sørensen, S. A., Andersen, S. H., Jørgensen, T., Lynnerup, N., Lawson, D. J., Rasmussen, S., Korneliussen, T. S., Kjær, K. H., Durbin, R., Nielsen, R., Delaneau, O., Werge, T., Kristiansen, K. & Willerslev, E., 2024, In: Nature. 625, 7994, p. 329-337 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
    File
    11 Citations (Scopus)
    73 Downloads (Pure)

  • Clinical segmentation in 22q11.2 deletion syndrome: Cognitive impairments and additional genetic load

    Schmock, H., Stevenson, M. P., Hanebaum, S., Vangkilde, A., Rosengren, A., Weinsheimer, S. M., Skovby, F., Olesen, C., Ullum, H., Baaré, W. F. C., Siebner, H. R., Didriksen, M., Werge, T., Olsen, L. & Jepsen, J. R. M., 2024, In: Journal of Psychiatric Research. 177, p. 153-161 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  • Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

    Bergstedt, J., Pasman, J. A., Ma, Z., Harder, A., Yao, S., Parker, N., Treur, J. L., Smit, D. J. A., Frei, O., Shadrin, A. A., Meijsen, J. J., Shen, Q., Hägg, S., Tornvall, P., Buil, A., Werge, T., Hjerling-Leffler, J., Als, T. D., Børglum, A. D., Lewis, C. M. & 6 others, McIntosh, A. M., Valdimarsdóttir, U. A., Andreassen, O. A., Sullivan, P. F., Lu, Y. & Fang, F., 2024, In: Nature Cardiovascular Research. 3, 6, p. 754-769 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
    File
    5 Downloads (Pure)

  • Distinct genetic liability profiles define clinically relevant patient strata across common diseases

    Trastulla, L., Dolgalev, G., Moser, S., Jiménez-Barrón, L. T., Andlauer, T. F. M., von Scheidt, M., Ruderfer, D. M., Ripke, S., McQuillin, A., Stahl, E. A., Domenici, E., Adolfsson, R., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A. & 31 others, Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Blackwood, D. H. R., Borglum, A. D., Bramon, E., Bruggeman, R., Buccola, N. G., Buckner, R. L., Bulik-Sullivan, B., Buxbaum, J. D., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Hansen, M., Hansen, T., Li, T., Olsen, L., Pantelis, C., Pers, T. H., Rasmussen, H. B., Werge, T. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2024, In: Nature Communications. 15, 1, 28 p., 5534.

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
    File
    1 Citation (Scopus)
    1 Downloads (Pure)

  • Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-wide Association Study

    Breinbjerg, A., Jørgensen, C. S., Walters, G. B., Grove, J., Als, T. D., Kamperis, K., Stéfansdóttir, L., Thirstrup, J. P., Borg, B., Albiñana, C., Vilhjálmsson, B. J., Eðvarðsson, V., Stefánsson, H., Mortensen, P. B., Agerbo, E., Werge, T., Børglum, A., Demontis, D., Stefánsson, K., Rittig, S. & 1 others, Christensen, J. H., 2024, (Accepted/In press) In: Journal of Urology.

    Research output: Contribution to journal › Journal article › Research › peer-review

    1 Citation (Scopus)

  • Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

    Nievergelt, C. M., Maihofer, A. X., Atkinson, E. G., Chen, C. Y., Choi, K. W., Coleman, J. R. I., Daskalakis, N. P., Duncan, L. E., Polimanti, R., Aaronson, C., Amstadter, A. B., Andersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B., Avdibegoviç, E., Babić, D., Bacanu, S. A., Baker, D. G. & 215 others, Batzler, A., Beckham, J. C., Belangero, S., Benjet, C., Bergner, C., Bierer, L. M., Biernacka, J. M., Bierut, L. J., Bisson, J. I., Boks, M. P., Bolger, E. A., Brandolino, A., Breen, G., Bressan, R. A., Bryant, R. A., Bustamante, A. C., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Børglum, A. D., Børte, S., Cahn, L., Calabrese, J. R., Caldas-de-Almeida, J. M., Chatzinakos, C., Cheema, S., Clouston, S. A. P., Colodro-Conde, L., Coombes, B. J., Cruz-Fuentes, C. S., Dale, A. M., Dalvie, S., Davis, L. K., Deckert, J., Delahanty, D. L., Dennis, M. F., Desarnaud, F., DiPietro, C. P., Disner, S. G., Docherty, A. R., Domschke, K., Dyb, G., Kulenović, A. D., Edenberg, H. J., Evans, A., Fabbri, C., Fani, N., Farrer, L. A., Feder, A., Feeny, N. C., Flory, J. D., Forbes, D., Franz, C. E., Galea, S., Garrett, M. E., Gelaye, B., Gelernter, J., Geuze, E., Gillespie, C. F., Goleva, S. B., Gordon, S. D., Goçi, A., Grasser, L. R., Guindalini, C., Haas, M., Hagenaars, S., Hauser, M. A., Heath, A. C., Hemmings, S. M. J., Hesselbrock, V., Hickie, I. B., Hogan, K., Hougaard, D. M., Huang, H., Huckins, L. M., Hveem, K., Jakovljević, M., Javanbakht, A., Jenkins, G. D., Johnson, J., Jones, I., Jovanovic, T., Karstoft, K. I., Kaufman, M. L., Kennedy, J. L., Kessler, R. C., Khan, A., Kimbrel, N. A., King, A. P., Koen, N., Kotov, R., Kranzler, H. R., Krebs, K., Kremen, W. S., Kuan, P. F., Lawford, B. R., Lebois, L. A. M., Lehto, K., Levey, D. F., Lewis, C., Liberzon, I., Linnstaedt, S. D., Logue, M. W., Lori, A., Lu, Y., Luft, B. J., Lupton, M. K., Luykx, J. J., Makotkine, I., Maples-Keller, J. L., Marchese, S., Marmar, C., Martin, N. G., Martínez-Levy, G. A., McAloney, K., McFarlane, A., McLaughlin, K. A., McLean, S. A., Medland, S. E., Mehta, D., Meyers, J., Michopoulos, V., Mikita, E. A., Milani, L., Milberg, W., Miller, M. W., Morey, R. A., Morris, C. P., Mors, O., Mortensen, P. B., Mufford, M. S., Nelson, E. C., Nordentoft, M., Norman, S. B., Nugent, N. R., O’Donnell, M., Orcutt, H. K., Pan, P. M., Panizzon, M. S., Pathak, G. A., Peters, E. S., Peterson, A. L., Peverill, M., Pietrzak, R. H., Polusny, M. A., Porjesz, B., Powers, A., Qin, X. J., Ratanatharathorn, A., Risbrough, V. B., Roberts, A. L., Rothbaum, A. O., Rothbaum, B. O., Roy-Byrne, P., Ruggiero, K. J., Rung, A., Runz, H., Rutten, B. P. F., de Viteri, S. S., Salum, G. A., Sampson, L., Sanchez, S. E., Santoro, M., Seah, C., Seedat, S., Seng, J. S., Shabalin, A., Sheerin, C. M., Silove, D., Smith, A. K., Smoller, J. W., Sponheim, S. R., Stein, D. J., Stensland, S., Stevens, J. S., Sumner, J. A., Teicher, M. H., Thompson, W. K., Tiwari, A. K., Trapido, E., Uddin, M., Ursano, R. J., Valdimarsdóttir, U., Van Hooff, M., Vermetten, E., Vinkers, C. H., Voisey, J., Wang, Y., Wang, Z., Waszczuk, M., Weber, H., Wendt, F. R., Werge, T., Williams, M. A., Williamson, D. E., Winsvold, B. S., Winternitz, S., Wolf, C., Wolf, E. J., Xia, Y., Xiong, Y., Yehuda, R., Young, K. A., Young, R. M. D., Zai, C. C., Zai, G. C., Zervas, M., Zhao, H., Zoellner, L. A., Zwart, J. A., deRoon-Cassini, T., van Rooij, S. J. H., van den Heuvel, L. L., Stein, M. B., Ressler, K. J. & Koenen, K. C., 2024, In: Nature Genetics. 56, 5, p. 792-808 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    12 Citations (Scopus)

  • Identification of women at high risk of postpartum psychiatric episodes: A population-based study quantifying relative and absolute risks following exposure to selected risk factors and genetic liability

    Johannsen, B. M. W., Larsen, J. T., Liu, X., Madsen, K. B., Mægbæk, M. L., Albiñana, C., Bergink, V., Laursen, T. M., Bech, B. H., Mortensen, P. B., Nordentoft, M., Børglum, A. D., Werge, T., Hougaard, D. M., Agerbo, E., Petersen, L. V. & Munk-Olsen, T., 2024, (E-pub ahead of print) In: Acta Psychiatrica Scandinavica. 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
    3 Citations (Scopus)
View all 437 research outputs