Thomas Zeuthen

Search results

• 2022

  Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

  MacAulay, N., Keep, R. F. & Zeuthen, T., 2022, In: Fluids and Barriers of the CNS. 19, 1, 18 p., 26.

  Research output: Contribution to journal › Review › peer-review

  Open Access

  File
  75 Citations (Scopus)

  43 Downloads (Pure)

• Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

  Oernbo, E. K., Steffensen, A. B., Khamesi, P. R., Toft-Bertelsen, T. L., Barbuskaite, D., Vilhardt, F., Gerkau, N. J., Tritsaris, K., Simonsen, A. H., Lolansen, S. D., Andreassen, S. N., Hasselbalch, S. G., Zeuthen, T., Rose, C. R., Kurtcuoglu, V. & MacAulay, N., 2022, In: Fluids and Barriers of the CNS. 19, 1, 25 p., 65.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  26 Citations (Scopus)

  34 Downloads (Pure)
• 2016

  Structural and functional significance of water permeation through cotransporters

  Zeuthen, T., Gorraitz, E., Her, K., Wright, E. M. & Loo, D. D. F., 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. E6887-E6894

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)
• 2014

  Local impermeant anions establish the neuronal chloride concentration

  Glykys, J., Dzhala, V., Egawa, K., Balena, T., Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, T. & Staley, K. J., 7 Feb 2014, In: Science (New York, N.Y.). 343, 6171, p. 670-5 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  162 Citations (Scopus)

• Response to comments on "Local impermeant anions establish the neuronal chloride concentration"

  Glykys, J., Dzhala, V., Egawa, K., Balena, T., Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, T. & Staley, K. J., 5 Sept 2014, In: Science (New York, N.Y.). 345, 6201, 2 p., 1130-D.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)
• 2013

  Osmotic water transport in aquaporins: evidence for a stochastic mechanism

  Zeuthen, T., Alsterfjord, M., Beitz, E. & MacAulay, N., 15 Oct 2013, In: Journal of Physiology. 591, Pt 20, p. 5017-29 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)
• 2012

  Cotransport of water by Na¿-K¿-2Cl¿ cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2

  Zeuthen, T. & Macaulay, N., 1 Mar 2012, In: Journal of Physiology. 590, Pt 5, p. 1139-54 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  82 Citations (Scopus)

• Glial K(+) Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps

  Macaulay, N. & Zeuthen, T., Nov 2012, In: Neurochemical Research. 37, 11, p. 2299-2309 11 p.

  Research output: Contribution to journal › Review › peer-review
  98 Citations (Scopus)
• 2011

  Enhancement of proton conductance by mutations of the selectivity filter of aquaporin-1

  Li, H., Chen, H., Steinbronn, C., Wu, B., Beitz, E., Zeuthen, T. & Voth, G. A., 8 Apr 2011, In: Journal of Molecular Biology. 407, 4, p. 607-20 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  62 Citations (Scopus)

• Requirement for asparagine in the aquaporin NPA sequence signature motifs for cation exclusion

  Wree, D., Wu, B., Zeuthen, T. & Beitz, E., 1 Mar 2011, In: FEBS Journal. 278, 5, p. 740-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  50 Citations (Scopus)
• 2010

  Cotransport of water by the Na+-K+-2Cl(-) cotransporter NKCC1 in mammalian epithelial cells

  Hamann, S., Herrera-Perez, J. J., Zeuthen, T., Alvarez-Leefmans, F. J., Hamann, S., Herrera-Perez, J. J., Zeuthen, T. & Alvarez-Leefmans, F. J., 1 Nov 2010, In: Journal of Physiology. 588, Pt 21, p. 4089-101 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  101 Citations (Scopus)

• Water transport between CNS compartments: contributions of aquaporins and cotransporters

  MacAulay, N. & Zeuthen, T., Jul 2010, In: Neuroscience. 168, 4, p. 941-56 15 p.

  Research output: Contribution to journal › Review › peer-review
  175 Citations (Scopus)

• Water-transporting proteins

  Zeuthen, T., 2010, In: Journal of Membrane Biology. 234, 2, p. 57-73 16 p.

  Research output: Contribution to journal › Review
  163 Citations (Scopus)
• 2009

  Ammonia and urea permeability of mammalian aquaporins

  Litman, T., Søgaard, R. & Zeuthen, T., 2009, In: Handbook of Experimental Pharmacology. 190, p. 327-58 31 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  106 Citations (Scopus)

• Ammonium ion transport by the AMT/Rh homolog TaAMT1;1 is stimulated by acidic pH

  Søgaard, R., Alsterfjord, M., Macaulay, N. & Zeuthen, T., 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 733-43 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  46 Citations (Scopus)

• Analysis of mice with targeted deletion of AQP9 gene provides conclusive evidence for expression of AQP9 in neurons

  Mylonakou, M. N., Petersen, P. H., Rinvik, E., Rojek, A., Valdimarsdottir, E., Zelenin, S., Zeuthen, T., Nielsen, S., Ottersen, O. P. & Amiry-Moghaddam, M., 2009, In: Journal of Neuroscience Research. 87, 6, p. 1310-22 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)

• Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space

  Østby, I., Øyehaug, L., Einevoll, G. T., Nagelhus, E. A., Plahte, E., Zeuthen, T., Lloyd, C. M., Ottersen, O. P. & Omholt, S. W., 2009, In: PLoS Computational Biology. 5, 1, p. e1000272

  Research output: Contribution to journal › Journal article › Research › peer-review
  101 Citations (Scopus)

• Chloride transporters as water pumps: Elements in a new model of epithelial water transport: From Molecules to diseases

  MacAulay, N., Hamann, S. & Zeuthen, T., 2009, Physiology and pathology of chloride transporters and channels in the nervous system. Alvarez-Leefmans, F. & Delpire, E. (eds.). Amsterdam, The Netherlands: Academic Press, p. 547-568 22 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Concerted action of two cation filters in the aquaporin water channel

  Wu, B., Steinbronn, C., Alsterfjord, M., Zeuthen, T. & Beitz, E., 2009, In: EMBO Journal. 28, 15, p. 2188-2194 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  81 Citations (Scopus)

• Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes

  Moeller, H. B., Fenton, R. A., Zeuthen, T. & Macaulay, N., Dec 2009, In: Neuroscience. 164, 4, p. 1674-84 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  56 Citations (Scopus)
• 2008

  New isoforms of rat Aquaporin-4.

  Moe, S. E., Sorbo, J. G., Søgaard, R., Zeuthen, T., Petter Ottersen, O. & Holen, T., 2008, In: Genomics. 91, 4, p. 367-77 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  94 Citations (Scopus)
• 2007

  Molecular water pumps: or how water can move uphill across epithelia

  Zeuthen, T., 2007, In: Physiology News. 68, p. 3-5 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Test of blockers of AQP1 water permeability by a high-resolution method: no effects of tetraethylammonium ions or acetazolamide.

  Søgaard, R. & Zeuthen, T., 2007, In: Pflügers Archiv: European Journal of Physiology. 456, 2, p. 285-92 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  51 Citations (Scopus)

• The mechanism of water transport in Na+-coupled glucose transporters expressed in Xenopus oocytes

  Zeuthen, T., 2007, In: Biophysical Journal. 93, 4, p. 1413-1416 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  19 Citations (Scopus)

• Water transport by GLUT2 expressed in Xenopus laevis oocytes

  Zeuthen, T., Zeuthen, E. & MacAulay, N., 2007, In: Journal of Physiology. 579, 2, p. 345-361 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  39 Citations (Scopus)
• 2006

  Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei

  Zeuthen, T., Wu, B. H., Pavlovic-Djuranovic, S., Holm, L. M., Uzcategui, N. L., Duszenko, M., Kun, J. F. J., Schultz, J. E. & Beitz, E., 2006, In: Molecular Microbiology. 61, 6, p. 1598-1608 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  72 Citations (Scopus)

• Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia and protons

  Beitz, E., Wu, B., Holm, L. M., Schultz, J. E. & Zeuthen, T., 2006, In: Proceedings of the National Academy of Science of the United States of America. 103(2), p. 269-274

  Research output: Contribution to journal › Journal article › Research › peer-review
  294 Citations (Scopus)
• 2005

  NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes

  Holm, L. M., Jahn, T. P., Møller, A. L. B., Schjørring, J. K., Ferri, D., Klærke, D. A. & Zeuthen, T., 2005, In: Pflügers Archiv: European Journal of Physiology. 450, 6, p. 415-428 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  221 Citations (Scopus)

• Water permeability of Na+-K+-2C1- cotransporters in mammalian epithelial cells

  Hammann, S., Herrera-Perez, J. J., Bundgaard, M., Alvarez-Leefmans, F. J. & Zeuthen, T., 2005, In: Journal of Physiology. 568, p. 123-135

  Research output: Contribution to journal › Journal article › Research › peer-review
  68 Citations (Scopus)

• Water transport by Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substrate size studied at high resolution

  Zeuthen, T., Belhage, B. & Zeuthen, E., 2005, In: Journal of Physiology. 570, 3, p. 485-99 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  58 Citations (Scopus)
• 2004

  Aquaporin 6 is permeable to glycerol and urea

  Holm, L. M., Klærke, D. A. & Zeuthen, T., 2004, In: Pflügers Archiv: European Journal of Physiology. 448, p. 181-186 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  46 Citations (Scopus)

• Aquaporin homologues in plants and mammals transport ammonia

  Jahn, T. P., Møller, A. L. B., Zeuthen, T., Holm, L. M., Klærke, D. A., Mohsin, B., Kühlbrandt, W. & Schjørring, J. K., 2004, In: FEBS Letters. 574, 1-3, p. 31-36 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  284 Citations (Scopus)

• Molecular cloning of a K⁺ channel from the malaria parasite Plasmodium falciparum

  Ellekvist, P., Ricke, C. H., Litman, T., Salanti, A., Colding, H., Zeuthen, T. & Klaerke, D. A., 2004, In: Biochemical and Biophysical Research Communications. 318, 2, p. 477-84 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Water transport in brain: Role of cotransporters

  MacAulay, N., Hamann, S. & Zeuthen, T., 2004, In: Neuroscience. 129, 4, p. 1031-1044

  Research output: Contribution to journal › Journal article › Research › peer-review
  102 Citations (Scopus)
• 2003

  Cotransport of H⁺, lactate, and H₂O in porcine retinal pigment epithelial cells

  Hamann, S., Kiilgaard, J. F., Cour, M. L., Prause, J. U. & Zeuthen, T., 2003, In: Experimental Eye Research. 76, p. 493-504

  Research output: Contribution to journal › Journal article › Research › peer-review

• Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

  MacAulay, N., Meinild, A.-K., Zeuthen, T. & Gether, U., 2003, In: Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 2002

  Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1

  MacAulay, N., Zeuthen, T. & Gether, U., 15 Oct 2002, In: Journal of Physiology. 544, Pt 2, p. 447-58 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  45 Citations (Scopus)

• Conformational basis for the Li⁺- induced leak current in the rat ¿- aminobutyric acid (GABA) transporter- 1

  MacAulay, N., Zeuthen, T. & Gether, U., 2002, In: Journal of Physiology. 544, 2, p. 447-458

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)

• Cotransporters as molecular water pumps

  Zeuthen, T. & MacAulay, N., 2002, In: International Review of Cytology. 215, p. 259-84 25 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  39 Citations (Scopus)

• General models for water transport across leaky epithelia

  Zeuthen, T., 2002, In: International Review of Cytology. 215, p. 285-317

  Research output: Contribution to journal › Journal article › Research › peer-review

  37 Citations (Scopus)

• Measurement of cell volume changes by fluorescence self-quenching

  Hamann, S., Kiilgaard, J. F., Litman, T., Alvarez-Leefmans, F. J., Winther, B. R. & Zeuthen, T., 2002, In: Journal of Fluorescence. 12, 2, p. 139-145 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  161 Citations (Scopus)

• Mobility of ions, sugar, and water in the cytoplasm of Xenopus oocytes expressing Na (+)-coupled sugar transporters (SGLT1)

  Zeuthen, T., Zeuthen, E. & Klærke, D. A., 2002, In: Journal of Physiology. 542, p. 71-87

  Research output: Contribution to journal › Journal article › Research › peer-review
  57 Citations (Scopus)

• Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes

  Macaulay, N., Gether, U., Klærke, D. A. & Zeuthen, T., 2002, In: Journal of Physiology. 542, 3, p. 817-828 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Passive water transport in biological pores

  Zeuthen, T. & Macaulay, N., 2002, In: International Review of Cytology. 215, p. 203-230

  Research output: Contribution to journal › Journal article › Research › peer-review

  17 Citations (Scopus)

• Water pumps

  Loo, D. D. F., Wright, E. M. & Zeuthen, T., 2002, In: Journal of Physiology. 542, p. 53-60

  Research output: Contribution to journal › Journal article › Research › peer-review
  166 Citations (Scopus)
• 2001

  Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

  Macaulay, N., Bendahan, A., Løland, C. J., Zeuthen, T., Kanner, B. I. & Gether, U., 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)

• Isotonic transport by the Na+-glucose cotransporter SGLT1 from humans and rabbit.

  Zeuthen, T., Meinild, A. K., Loo, D. D., Wright, E. M. & Klaerke, D. A., 2001, In: Journal of Physiology. 531, 3, p. 631-44 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  82 Citations (Scopus)
• 2000

  Transport of protons and lactate in cultured human fetal retinal pigment epithelial cells

  Hamann, S., Cour, M. L., Ming Lui, G., Bundgaard, M. & Zeuthen, T., 2000, In: Pflügers Archiv: European Journal of Physiology. 440, p. 84-92

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Water transport by the renal Na(+)-dicarboxylate cotransporter.

  Meinild, A. K., Loo, D. D., Pajor, A. M., Zeuthen, T. & Wright, E. M., 2000, In: American Journal of Physiology - Renal Physiology. 278, 5, p. F777-83

  Research output: Contribution to journal › Journal article › Research › peer-review
  53 Citations (Scopus)
• 1999

  Commentary on "Epithelial Fluid Transport--A Century of Investigation"

  Loo, D. D. F., Wright, E. M., Meinild, A.-K., Klaerke, D. A. & Zeuthen, T., 1999, In: Physiology. 14, 3, p. 98-100 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)