Tommy Nørskov Johansen

Research output

Research output per year 1994 1997 1998 2001 2002 2005 2007 2008 2017 2024

• 1117 Citations
• 46 Journal article
• 3 Book chapter
• 1 Conference abstract in journal

Research output per year

Research output per year

Search results

• 2024

  Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand

  Chałupnik, P., Marek, A., Hovah, M. E. L., Pickering, D. S., Temperini, P., Donbosco, S., Szymańska, E. & Johansen, T. N., 2024, In: Journal of Labelled Compounds and Radiopharmaceuticals. 67, 4, p. 120-130

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Downloads (Pure)
• 2023

  Structure-Activity Relationship and Solubility Studies of Novel N1-substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists

  Chałupnik, P., Vialko, A., Pickering, D. S., Nielsen, B., Bay, Y., Kristensen, A. S., Hinkkanen, M., Szczepańska, K., Karcz, T., Latacz, G., Johansen, T. N. & Szymanska, E. M., 2023, In: ChemMedChem. 18, 18, 15 p., e202300278.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  4 Downloads (Pure)
• 2022

  Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

  Chałupnik, P., Vialko, A., Pickering, D. S., Hinkkanen, M., Donbosco, S., Møller, T. C., Jensen, A. A., Nielsen, B., Bay, Y., Kristensen, A. S., Johansen, T. N., Łątka, K., Bajda, M. & Szymańska, E., 2022, In: International Journal of Molecular Sciences. 23, 15, 16 p., 8797.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Citations (Scopus)

  53 Downloads (Pure)
• 2021

  Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

  Pallesen, J. S., Narayanan, D., Tran, K. T., Solbak, S. M. Ø., Marseglia, G., Sørensen, L. M. E., Høj, L. J., Munafò, F., Carmona, R. M. C., Garcia, A. D., Desu, H. L., Brambilla, R., Johansen, T. N., Popowicz, G. M., Sattler, M., Gajhede, M. & Bach, A., 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4623–4661

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  35 Citations (Scopus)

  30 Downloads (Pure)
• 2019

  N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology

  Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, P., Pasini, D., Bornholdt, J., Nielsen, B., Mamedova, E., Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen, J. T., Frydenvang, K., Kastrup, J. S., Johansen, T. N. & Pickering, D. S., 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

  Pallesen, J. S., Møllerud, S., Frydenvang, K. A., Pickering, D. S., Bornholt, J., Nielsen, B., Pasini, D., Han, L., Marconi, L., Kastrup, J. S. J. & Johansen, T. N., 20 Mar 2019, In: A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 2017

  Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands

  Szymańska, E., Chałupnik, P., Johansen, T. N., Nielsen, B., Cuñado Moral, A. M., Pickering, D. S. & Kieć-Kononowicz, K., 1 Dec 2017, In: Chemical Biology & Drug Design. 90, p. 1271-1281 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors

  Szymańska, E., Nielsen, B., Johansen, T. N., Cuñado Moral, A. M., Pickering, D. S., Szczepańska, K., Mickowska, A. & Kieć-Kononowicz, K., 2017, In: European Journal of Medicinal Chemistry. 138, p. 874-883 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

  Møllerud, S., Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, T. N., Kastrup, J. S., Pickering, D. S. & Frydenvang, K. A., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2016

  Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

  Szymańska, E., Chałupnik, P., Szczepańska, K., Moral, A. M. C., Pickering, D. S., Nielsen, B., Johansen, T. N. & Kieć-Kononowicz, K-K., 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 22, p. 5568-5572 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

  Szymanska, E., Frydenvang, K. A., Pickering, D. S., Krintel, C., Nielsen, B., Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, J. S. J. & Johansen, T. N., 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)
• 2014

  Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

  Sköld, N., Nielsen, B., Olsen, J., Han, L., Olsen, L., Madsen, U., Kristensen, J. L., Pickering, D. S. & Johansen, T. N., 2 Aug 2014, In: Bioorganic & Medicinal Chemistry. 22, 19, p. 5368-5377 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2012

  Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors

  Venskutonyte, R., Frydenvang, K., Valadés, E. A., Szymanska, E. M., Johansen, T. N., Kastrup, J. S. & Pickering, D. S., Oct 2012, In: ChemMedChem. 7, 10, p. 1793-1798 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)
• 2011

  A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

  Szymanska, E., Frydenvang, K., Contreras-Sanz, A., Pickering, D. S., Frola, E., Serafimoska, Z., Nielsen, B., Kastrup, J. S. & Johansen, T. N., 4 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2010

  4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

  Lolli, M. L., Giordano, C., Pickering, D. S., Rolando, B., Hansen, K. B., Foti, A., Contreras-Sanz, A., Amir, A., Fruttero, R., Gasco, A., Nielsen, B. & Johansen, T. N., 2010, In: Journal of Medicinal Chemistry. 53, 10, p. 4110-8 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones

  Christensen, M. K., Erichsen, K. D., Trojel-Hansen, C., Tjørnelund, J., Nielsen, S. J., Frydenvang, K. A., Johansen, T. N., Nielsen, B., Sehested, M., Jensen, P. B., Ikaunieks, M., Zaichenko, A., Loza, E., Kalvinsh, I. & Björkling, F., 14 Oct 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7140-7145 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  59 Citations (Scopus)
• 2009

  3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands

  Szymanska, E., Pickering, D. S., Nielsen, B. & Johansen, T. N., 2009, In: Bioorganic & Medicinal Chemistry. 17, 17, p. 6390-401 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)
• 2008

  Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies

  Madsen, K. G., Skonberg, C., Jurva, U., Cornett, C., Hansen, S. H., Johansen, T. N. & Olsen, J., 2008, In: Chemical Research in Toxicology. 21, 5, p. 1107-19 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  78 Citations (Scopus)

• Palladium-catalyzed monoamination of dihalogenated benzenes

  Larsen, S. B., Bang-Andersen, B., Johansen, T. N. & Jørgensen, M., 2008, In: Tetrahedron. 64, 13, p. 2938-2950

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency

  Beich-Frandsen, M., Pickering, D. S., Mirza, O., Johansen, T. N., Greenwood, J., Vestergaard, B., Schousboe, A., Gajhede, M., Liljefors, T. & Kastrup, J. S., 2008, In: Journal of Medicinal Chemistry. 51, 5, p. 1459-63

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)
• 2007

  A tetrazolyl-substituted subtype-selective AMPA receptor agonist

  Vogensen, S. B., Frydenvang, K. A., Greenwood, J. R., Postorino, G., Nielsen, B., Pickering, D. S., Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, M., Kastrup, J. S. J., Johansen, T. N., Clausen, R. P. & Krogsgaard-Larsen, P., 2007, In: Journal of Medicinal Chemistry. 50, 10, p. 2408-2414

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA

  Jensen, A. A., Christesen, T., Bølcho, U., Greenwood, J. R., Postorino, G., Vogensen, S. B., Johansen, T. N., Egebjerg, J., Bräuner-Osborne, H. & Clausen, R. P., 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4177-4185 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Selektive lægemiddelstoffer designet ud fra krystalstrukturer

  Szymanska, E. M. & Johansen, T. N., 2007, In: Lægemiddelforskning. p. 34-35

  Research output: Contribution to journal › Journal article › Communication

  Open Access

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  1640 Downloads (Pure)
• 2006

  Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

  Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, B., Wellendorph, P., Madsen, K., Larsen, O. M., Kristiansen, U., Fruttero, R., Gasco, A. & Johansen, T. N., 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  29 Citations (Scopus)
• 2005

  Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues

  Vogensen, SB., Clausen, R. P., Greenwood, JR., Johansen, T. N., Pickering, DS., Nielsen, B., Ebert, B. & Krogsgaard-Larsen, P., 5 May 2005, In: Journal of Medicinal Chemistry. 48, 9, p. 3438-3442

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders

  Madsen, U., Bräuner-Osborne, H., Greenwood, J. R., Johansen, T. N., Krogsgaard-Larsen, P., Liljefors, T., Nielsen, M. & Frølund, B., 27 Jan 2005, Drug Discovery Handbook. John Wiley & Sons, Inc., p. 797-907 111 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  11 Citations (Scopus)

• GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders

  Madsen, U., Greenwood, J., Johansen, T. N., Krogsgaard-Larsen, P., Liljefors, T., Nielsen, M. & Frølund, B., 2005, Drug Discovery Handbook. Wiley, p. 797–907

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 2004

  A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors

  Vogensen, SB., Greenwood, JR., Varming, A. R., Brehm, L., Pickering, DS., Nielsen, B., Liljefors, T., Clausen, R. P., Johansen, T. N. & Krogsgaard-Larsen, P., 2004, In: Organic & Biomolecular Chemistry. 2, 2, p. 206-213

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)
• 2003

  Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors

  Johansen, T. N., Greenwood, J. R., Frydenvang, K. A., Madsen, U. & Krogsgaard-Larsen, P., 2003, In: Chirality. 15, 2, p. 167-79 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)
• 2002

  2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

  Johansen, T. N., Janin, Y. L., Nielsen, B., Frydenvang, K. A., Bräuner-Osborne, H., Stensbøl, T. B., Vogensen, S. B., Madsen, U. & Krogsgaard-Larsen, P., 2002, In: Bioorganic & Medicinal Chemistry. 10, 7, p. 2259-66 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  24 Citations (Scopus)

• Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

  Guldbrandt, M., Johansen, T. N., Frydenvang, K. A., Bräuner-Osborne, H., Stensbøl, T. B., Nielsen, B., Karla, R., Santi, F., Krogsgaard-Larsen, P. & Madsen, U., 2002, In: Chirality. 14, 4, p. 351-63 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors

  Jensen, A. A., Mosbacher, J., Elg, S., Lingenhoehl, K., Lohmann, T., Johansen, T. N., Abrahamsen, B., Mattsson, J., Lehmann, A., Bettler, B. & Bräuner-Osborne, H., 2002, In: Molecular Pharmacology. 61, 6, p. 1377-84 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  104 Citations (Scopus)
• 2001

  Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA

  Johansen, T. N., Stensbøl, T. B., Nielsen, B., Vogensen, S. B., Frydenvang, K. A., Sløk, F. A., Bräüner-Osborne, H., Madsen, U. & Krogsgaard-Larsen, P., 2001, In: Chirality. 13, 9, p. 523-32 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist

  Stensbøl, T. B., Jensen, H. S., Nielsen, B., Johansen, T. N., Egebjerg, J., Frydenvang, K. A. & Krogsgaard-Larsen, P., 2001, In: European Journal of Pharmacology. 411, 3, p. 245-53 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  18 Citations (Scopus)

• Structural and stereochemical requirements for activation and blocade of excitatory amino acid receptors

  Sløk, F. A., Bräuner-Osborne, H., Stensbøl, T. B., Johansen, T. N., Ebert, B., Mortensen, M., Nielsen, B., Madsen, U., Brehm, L., Falch, E. & Krogsgaard-Larsen, P., 2001, Medicinal Chemistry into the Millenium. Campbell, M. M. & Blagbrough, I. S. (eds.). UK: Royal Society of Chemistry, p. 52-64 13 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors

  Madsen, U., Bräuner-Osborne, H., Frydenvang, K. A., Hvene, L., Johansen, T. N., Nielsen, B., Sánchez, C., Stensbøl, T. B., Bischoff, F. & Krogsgaard-Larsen, P., 2001, In: Journal of Medicinal Chemistry. 44, 7, p. 1051-9 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  21 Citations (Scopus)

• Synthesis and receptor binding affinity of new selective GluR5 ligands

  Bunch, L., Johansen, T. H., Bräuner-Osborne, H., Stensbøl, T. B., Johansen, T. N., Krogsgaard-Larsen, P. & Madsen, U., Apr 2001, In: Bioorganic & Medicinal Chemistry. 9, 4, p. 875-9

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)
• 2000

  A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2

  Bräuner-Osborne, H., Hermit, M. B., Nielsen, B., Krogsgaard-Larsen, P. & Johansen, T. N., 6 Oct 2000, In: European Journal of Pharmacology. 406, 1, p. 41-4

  Research output: Contribution to journal › Journal article › Research › peer-review

  18 Citations (Scopus)

• Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist

  Vogensen, S. B., Jensen, H. S., Stensbøl, T. B., Frydenvang, K. A., Bang-Andersen, B., Johansen, T. N., Egebjerg, J. & Krogsgaard-Larsen, P., 2000, In: Chirality. 12, 10, p. 705-13 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)
• 1999

  3-pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing

  Zimmermann, D., Janin, Y. L., Brehm, L., Bräuner-Osborne, H., Ebert, B., Johansen, T. N., Madsen, U. & Krogsgaard-Larsen, P., 1 Nov 1999, In: European Journal of Medicinal Chemistry. 34, 11, p. 967-976

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Synthesis and Pharmacology of the Baclofen Homologues. 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R- and S-Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid

  Karla, R., Ebert, B., Thorkildsen, C., Herdeis, C., Johansen, T. N., Nielsen, B. & Krogsgaard-Larsen, P., 1999, In: Journal of Medicinal Chemistry. 42, p. 2053-2059 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)
• 1998

  Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects

  Skjærbæk, N., Brehm, L., Johansen, T. N., Hansen, L. M., Nielsen, B., Ebert, B., Søby, K., Stensbøl, T. B., Falch, E. & Krogsgaard-Larsen, P., 1998, In: Bioorganic & Medicinal Chemistry. 6, 1, p. 119-131 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  14 Citations (Scopus)

• Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid

  Johansen, T. N., Ebert, B., Bräuner-Osborne, H., Didriksen, M., Christensen, I. T., Søby, K. K., Madsen, U., Krogsgaard-Larsen, P. & Brehm, L., 12 Mar 1998, In: Journal of Medicinal Chemistry. 41, 6, p. 930-9

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)

• Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships

  Falch, E., Brehm, L., Mikkelsen, I., Johansen, T. N., Skjærbæk, N., Nielsen, B., Stensbøl, T. B., Ebert, B. & Krogsgaard-Larsen, P., 1998, In: Journal of Medicinal Chemistry. 41, p. 2513-2523 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  41 Citations (Scopus)
• 1997

  (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

  Ahmadian, H., Nielsen, B., Bräuner-Osborne, H., Johansen, T. N., Stensbøl, T. B., Sløk, F. A., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, P. & Madsen, U., 24 Oct 1997, In: Journal of Medicinal Chemistry. 40, 22, p. 3700-5

  Research output: Contribution to journal › Journal article › Research › peer-review
  61 Citations (Scopus)

• Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA)

  Johansen, T. N., Frydenvang, K. A., Ebert, B., Madsen, U. & Krogsgaard-Larsen, P., 1997, In: Chirality. 9, 5-6, p. 529-36 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors

  Bräuner-Osborne, H., Nielsen, B., Stensbøl, T. B., Johansen, T. N., Skjaerbaek, N. & Krogsgaard-Larsen, P., 24 Sep 1997, In: European Journal of Pharmacology. 335, 2-3, p. R1-3

  Research output: Contribution to journal › Journal article › Research › peer-review

  29 Citations (Scopus)
• 1996

  Design of excitatory amino acid receptor agonists, partial agonists and antagonists: Ibotenic acid as a key lead structure

  Krogsgaard-Larsen, P., Ebert, B., Lund, T. M., Bräuner-Osborne, H., Sloøk, F. A., Johansen, T. N., Brehm, L. & Madsen, U., 10 Sep 1996, In: European Journal of Medicinal Chemistry. 31, 7-8, p. 515-537 23 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  58 Citations (Scopus)

• N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

  Madsen, U., Frydenvang, K. A., Ebert, B., Johansen, T. N., Brehm, L. & Krogsgaard-Larsen, P., 1996, In: Journal of Medicinal Chemistry. 39, 1, p. 183-90 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)
• 1994

  Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands

  Johansen, T. N., Frydenvang, K. A., Ebert, B., Krogsgaard-Larsen, P. & Madsen, U., 1994, In: Journal of Medicinal Chemistry. 37, 20, p. 3252-62 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  19 Citations (Scopus)