Research output per year
Research output per year
Personal profile
Short presentation
Henrik Semb's research focus on elucidating basic mechanism in morphogenesis and how tissue architecture controls cell lineage commitment by using a combination of in vivo and in vitro genetic and cell biological experimental tools. Pancreas organogenesis in the mouse is used as model. We also use human pluripotent stem cells (hESCs/hiPSCs) as tools to study human pancreatic beta cell development and beta cell dysfunction in vitro as well as a source for transplantable beta cells in type 1 diabetes therapy.
For more information please visit the following webpages:
About Henrik Semb: http://danstem.ku.dk/people/semb_staff/semb/
Semb lab: http://danstem.ku.dk/research1/semb_laboratory/
Keywords
- Faculty of Health and Medical Sciences
- Human Embryonic Stem Cells
- pancreas
- endoderm
- pluripotency
- Induced Pluripotent Stem Cells (iPSC)
- Diabetes
- beta cells
- Insulin
- cell fate
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells
Hermann, F. M., Kjærgaard, M. F., Tian, C., Tiemann, U., Jackson, A., Olsen, L. R., Kraft, M., Carlsson, P. O., Elfving, I. M., Kettunen, J. L. T., Tuomi, T., Novak, I. & Semb, H., 2023, In: Cell Stem Cell. 30, 1, p. 38-51.e8 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)20 Downloads (Pure) -
Flow cytometry detection of surface and intracellular antigens in pancreas from a single mouse embryo
Nyeng, P., Dela Cruz, G. V. & Semb, T. H., 2021, In: STAR Protocols. 2, 3, 21 p., 100636.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)17 Downloads (Pure) -
Quantifying spatial position in a branched structure in immunostained mouse tissue sections
Heilmann, S., Semb, T. H. & Nyeng, P., 2021, In: STAR Protocols. 2, 4, 31 p., 100806.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile23 Downloads (Pure) -
In-Silico Staining from Bright-Field and Fluorescent Images Using Deep Learning
Waibel, D. J. E., Tiemann, U., Lupperger, V., Semb, H. & Marr, C., 2019, Artificial Neural Networks and Machine Learning – ICANN 2019: Image Processing. p. 184-186 Chapter 15. (Artificial Neural Networks and Machine Learning – ICANN 2019: Image Processing, Vol. 11729).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
2 Citations (Scopus) -
Mechanosignalling via integrins directs fate decisions of pancreatic progenitors
Mamidi, A., Prawiro, C., Seymour, P. A., de Lichtenberg, K. H., Jackson, A., Serup, P. & Semb, H., Dec 2018, In: Nature. 564, 7734, p. 114-118 5 p.Research output: Contribution to journal › Letter › Research › peer-review
155 Citations (Scopus) -
Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors
Ameri, J., Borup, R., Prawiro, C., Ramond, C., Schachter, K., Scharfmann, R. & Semb, T. H., 4 Apr 2017, In: Cell Reports. 19, 1, p. 36-49 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access94 Citations (Scopus) -
EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
Löf-Öhlin, Z. M., Nyeng, P., Bechard, M. E., Hess, K., Bankaitis, E., Greiner, T. U., Ameri, J., Wright, C. V. & Semb, H., Nov 2017, In: Nature Cell Biology. 19, 11, p. 1313-1325 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
41 Citations (Scopus) -
Reconstructing human pancreatic differentiation by mapping specific cell populations during development
Ramond, C., Glaser, N., Berthault, C., Ameri, J., Kirkegaard, J. S., Hansson, M., Honoré, C., Semb, T. H. & Scharfmann, R., 2017, In: eLife. 6, 22 p., e27564.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile43 Citations (Scopus)273 Downloads (Pure)