Tuomas Oskari Kilpeläinen

Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.

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Tuomas Kilpeläinen is an Associate Professor at the Novo Nordisk Foundation Center for Basic Metabolic Research (Denmark) and a Visiting Scientist at the Broad Institute of MIT and Harvard (USA). He completed his PhD at the University of Kuopio (Finland) and a 3-year postdoc at the University of Cambridge (UK). In 2015-2016, he was a Visiting Scientist and an Adjunct Assistant Professor at the Icahn School of Medicine at Mount Sinai (New York). Tuomas leads an inter-disciplinary research group that studies the genomics of obesity and metabolic health. His goal is to advance our understanding of obesity-related cardiometabolic disease by uncovering the mechanisms of action of genetic risk variants, particularly in adipose tissue.

10830 Citations
98 Journal article
8 Conference abstract in journal
4 Review
3 Book chapter
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A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
de Vries, P. S., Reventun, P., Brown, M. R., Heath, A. S., Huffman, J. E., Le, N. Q., Bebo, A., Brody, J. A., Temprano-Sagrera, G., Raffield, L. M., Ozel, A. B., Thibord, F., Jain, D., Lewis, J. P., Rodriguez, B. A. T., Pankratz, N., Taylor, K. D., Polasek, O., Chen, M. H., Yanek, L. R. & 32 others, Carrasquilla, G. D., Marioni, R. E., Kleber, M. E., Trégouët, D. A., Yao, J., Li-Gao, R., Joshi, P. K., Trompet, S., Martinez-Perez, A., Ghanbari, M., Howard, T. E., Reiner, A. P., Arvanitis, M., Ryan, K. A., Bartz, T. M., Rudan, I., Faraday, N., Linneberg, A., Ekunwe, L., Davies, G., Delgado, G. E., Hansen, T., Chen, W. M., Jackson, R., Liu, Y., Loos, R. J. F., Rao, D. C., Wang, L., Nielsen, J. B., Kilpeläinen, T. O., Trans-Omics for Precision Medicine (TOPMed) program & the INVENT consortium, 2024, In: Blood. 143, 18, p. 1845-1855
Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)
Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
Carrasquilla, G. D., Ängquist, L., Sørensen, T. I. A., Kilpeläinen, T. O. & Loos, R. J. F., 2024, In: Diabetologia. 67, p. 864–873 10 p.
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1 Citation (Scopus)

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Estimating causality between smoking and abdominal obesity by Mendelian randomization
Carrasquilla, G. D., García-Ureña, M., Romero-Lado, M. J. & Kilpeläinen, T. O., 2024, In: Addiction. 119, p. 1024-1034
Research output: Contribution to journal › Journal article › Research › peer-review

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Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment
Fadahunsi, N., Petersen, J. O., Metz, S., Jakobsen, A., Mathiesen, C. V., Buch-Rasmussen, A. S., Kurgan, N. K., Larsen, J. K., Andersen, R. C., Topilko, T., Svendsen, C., Apuschkin, M., Skovbjerg, G., Schmidt, J. H., Houser, G. A., Jager, S. E., Bach, A., Deshmukh, A. S., Kilpeläinen, T. O., Strømgaard, K. & 2 others, Madsen, K. L. & Clemmensen, C., 2024, In: Science Advances. 10, 9, 20 p., eadg2636.
Research output: Contribution to journal › Journal article › Research › peer-review

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1 Citation (Scopus)

34 Downloads (Pure)
Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss
Christiansen, M. R., Kilpelöainen, T. O. & McCaffery, J. M., 2023, In: Diabetes. 72, 10, p. 1424-1432 9 p.
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4 Citations (Scopus)

2 Downloads (Pure)
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C. Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A., Kolčić, I. & 178 others, Lim, E., Liu, Y., Manning, A. K., Marten, J., Musani, S. K., Noordam, R., Padmanabhan, S., Rankinen, T., Richard, M. A., Ridker, P. M., Smith, A. V., Vojinovic, D., Zonderman, A. B., Alver, M., Boissel, M., Christensen, K., Freedman, B. I., Gao, C., Giulianini, F., Harris, S. E., He, M., Hsu, F. C., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L. P., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Robino, A., Sofer, T., Takeuchi, F., Tayo, B. O., van der Most, P. J., Verweij, N., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhan, Y., Amin, N., Arking, D. E., Ballantyne, C., Boerwinkle, E., Brody, J. A., Broeckel, U., Campbell, A., Canouil, M., Chai, X., Chen, Y. D. I., Chen, X., Chitrala, K. N., Concas, M. P., de Faire, U., de Mutsert, R., de Silva, H. J., de Vries, P. S., Do, A., Faul, J. D., Fisher, V., Floyd, J. S., Forrester, T., Friedlander, Y., Girotto, G., Gu, C. C., Hallmans, G., Heikkinen, S., Heng, C. K., Homuth, G., Hunt, S., Ikram, M. A., Jacobs, D. R., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Komulainen, P., Langefeld, C. D., Liang, J., Liu, K., Liu, J., Lohman, K., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Milaneschi, Y., Nauck, M., Nelson, C. P., O’Connell, J. R., Palmer, N. D., Pereira, A. C., Perls, T., Peters, A., Polašek, O., Raitakari, O. T., Rice, K., Rice, T. K., Rich, S. S., Sabanayagam, C., Schreiner, P. J., Shu, X. O., Sidney, S., Sims, M., Smith, J. A., Starr, J. M., Strauch, K., Tai, E. S., Taylor, K. D., Tsai, M. Y., Uitterlinden, A. G., van Heemst, D., Waldenberger, M., Wang, Y. X., Wei, W. B., Wilson, G., Xuan, D., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Becker, D. M., Bonnefond, A., Bowden, D. W., Cooper, R. S., Deary, I. J., Divers, J., Esko, T., Franks, P. W., Froguel, P., Gieger, C., Jonas, J. B., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., North, K. E., Ntalla, I., Penninx, B., Samani, N. J., Snieder, H., Spedicati, B., van der Harst, P., Völzke, H., Wagenknecht, L. E., Weir, D. R., Wojczynski, M. K., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Chasman, D. I., Evans, M. K., Fox, E. R., Gudnason, V., Hayward, C., Horta, B. L., Kardia, S. L. R., Krieger, J. E., Mook-Kanamori, D. O., Peyser, P. A., Province, M. M., Psaty, B. M., Rudan, I., Sim, X., Smith, B. H., van Dam, R. M., van Duijn, C. M., Wong, T. Y., Arnett, D. K., Rao, D. C., Gauderman, J., Liu, C. T., Morrison, A. C., Rotter, J. I. & Fornage, M., 2023, In: Frontiers in Genetics. 14, 16 p., 1235337.
Research output: Contribution to journal › Journal article › Research › peer-review

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Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs
Drag, M. H., Debes, K. P., Franck, C. S., Flethøj, M., Lyhne, M. K., Møller, J. E., Ludvigsen, T. P., Jespersen, T., Olsen, L. H. & Kilpeläinen, T. O., 2023, In: Epigenetics. 18, 1, 17 p., 2199374.
Research output: Contribution to journal › Journal article › Research › peer-review

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40 Downloads (Pure)
Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
Huffman, J. E., Nicolas, J., Hahn, J., Heath, A. S., Raffield, L. M., Yanek, L. R., Brody, J. A., Thibord, F., Almasy, L., Bartz, T. M., Bielak, L. F., Bowler, R. P., Carrasquilla, G. D., Chasman, D. I., Chen, M-H., Emmert, D. B., Ghanbari, M., Haessle, J., Hottenga, J-J., Kleber, M. E. & 31 others, Le, N-Q., Lee, J., Lewis, J. P., Li-Gao, R., Luan, J., Malmberg, A., Mangino, M., Marioni, R. E., Martinez-Perez, A., Pankratz, N., Polasek, O., Richmond, A., Rodriguez, B. A., Rotter, J. I., Steri, M., Suchon, P., Trompet, S., Weiss, S., Zare, M., Auer, P., Cho, M. H., Christofidou, P., Davies, G., de Geus, E., Deleuze, J-F., Kilpeläinen, T. O., Linneberg, A., Grarup, N., Hansen, T., Pedersen, O. & VA Million Veteran Program, 2023, medRxiv, 20 p.
Research output: Working paper › Preprint › Research

Tuomas Oskari Kilpeläinen

Personal profile

Short presentation

Collaborations and top research areas from the last five years

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A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease

Estimating causality between smoking and abdominal obesity by Mendelian randomization

Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment

Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles

Tuomas Oskari Kilpeläinen

Personal profile

Short presentation

Collaborations and top research areas from the last five years

Research output