Tuomas Oskari Kilpeläinen

Search results

• 2025

  Refinement of a Published Gene-Physical Activity Interaction Impacting HDL-Cholesterol: Role of Sex and Lipoprotein Subfractions

  CHARGE Gene‐Lifestyle Interactions Working Group, Jan 2025, In: Genetic Epidemiology. 49, 1, p. e22607

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2024

  A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

  de Vries, P. S., Reventun, P., Brown, M. R., Heath, A. S., Huffman, J. E., Le, N. Q., Bebo, A., Brody, J. A., Temprano-Sagrera, G., Raffield, L. M., Ozel, A. B., Thibord, F., Jain, D., Lewis, J. P., Rodriguez, B. A. T., Pankratz, N., Taylor, K. D., Polasek, O., Chen, M. H., Yanek, L. R. & 32 others, Carrasquilla, G. D., Marioni, R. E., Kleber, M. E., Trégouët, D. A., Yao, J., Li-Gao, R., Joshi, P. K., Trompet, S., Martinez-Perez, A., Ghanbari, M., Howard, T. E., Reiner, A. P., Arvanitis, M., Ryan, K. A., Bartz, T. M., Rudan, I., Faraday, N., Linneberg, A., Ekunwe, L., Davies, G., Delgado, G. E., Hansen, T., Chen, W. M., Jackson, R., Liu, Y., Loos, R. J. F., Rao, D. C., Wang, L., Nielsen, J. B., Kilpeläinen, T. O., Trans-Omics for Precision Medicine (TOPMed) program & the INVENT consortium, 2024, In: Blood. 143, 18, p. 1845-1855

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease

  Carrasquilla, G. D., Ängquist, L., Sørensen, T. I. A., Kilpeläinen, T. O. & Loos, R. J. F., 2024, In: Diabetologia. 67, p. 864–873 10 p.

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• Estimating causality between smoking and abdominal obesity by Mendelian randomization

  Carrasquilla, G. D., García-Ureña, M., Romero-Lado, M. J. & Kilpeläinen, T. O., 2024, In: Addiction. 119, p. 1024-1034

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• NK2R control of energy expenditure and feeding to treat metabolic diseases

  Sass, F., Ma, T., Ekberg, J. H., Kirigiti, M., Ureña, M. G., Dollet, L., Brown, J. M., Basse, A. L., Yacawych, W. T., Burm, H. B., Andersen, M. K., Nielsen, T. S., Tomlinson, A. J., Dmytiyeva, O., Christensen, D. P., Bader, L., Vo, C. T., Wang, Y., Rausch, D. M., Kristensen, C. K. & 27 others, Gestal-Mato, M., In het Panhuis, W., Sjøberg, K. A., Kernodle, S., Petersen, J. E., Pavlovskyi, A., Sandhu, M., Moltke, I., Jørgensen, M. E., Albrechtsen, A., Grarup, N., Babu, M. M., Rensen, P. C. N., Kooijman, S., Seeley, R. J., Worthmann, A., Heeren, J., Pers, T. H., Hansen, T., Gustafsson, M. B. F., Tang-Christensen, M., Kilpeläinen, T. O., Myers, M. G., Kievit, P., Schwartz, T. W., Hansen, J. B. & Gerhart-Hines, Z., 2024, In: Nature. 635, 8040, p. 987–1000 37 p.

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• Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment

  Fadahunsi, N., Petersen, J. O., Metz, S., Jakobsen, A., Mathiesen, C. V., Buch-Rasmussen, A. S., Kurgan, N. K., Larsen, J. K., Andersen, R. C., Topilko, T., Svendsen, C., Christiansen, M., Skovbjerg, G., Schmidt, J. H., Houser, G. A., Jager, S. E., Bach, A., Deshmukh, A. S., Kilpeläinen, T. O., Strømgaard, K. & 2 others, Madsen, K. L. & Clemmensen, C., 2024, In: Science Advances. 10, 9, 20 p., eadg2636.

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• Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles

  Huffman, J. E., Nicholas, J., Hahn, J., Heath, A. S., Raffield, L. M., Yanek, L. R., Brody, J. A., Thibord, F., Almasy, L., Bartz, T. M., Bielak, L. F., Bowler, R. P., Carrasquilla, G. D., Chasman, D. I., Chen, M-H., Emmert, D. B., Ghanbari, M., Haessler, J., Hottenga, J. J., Kleber, M. E. & 116 others, Le, N-Q., Lee, J., Lewis, J. P., Li-Gao, R., Luan, J., Malmberg, A. L., Mangino, M., Marioni, R., Martinez-Perez, A., Pankratz, N., Polasek, O., Richmond, A., Rodriguez, B. A. T., Rotter, J. I., Steri, M., Suchon, P., Trompet, S., Weiss, S., Zare, M., Auer, P. L., Cho, M., Christofidou, P., Davies, G., de Geus, E. J., Deleuze, J-F., Delgado, G. E., Ekunwe, L., Faraday, N., Gogele, M., Greinacher, A., Gao, H., Howard, T. E., Joshi, P. K., Kilpeläinen, T. O., Lahti, J., Linneberg, A., Naitza, S., Noordam, R., Vergés, F. P., Rich, S. S., Rosendaal, F. R., Rudan, I., Ryan, K. A., Souto, J. C. C., van Rooij, F. J. A., Wang, H., Zhao, W., Becker, L., Beswick, A., Brown, M. R., Cade, B., Campbell, H., Cho, K., Crapo, J., Curran, J., de Maat, M. P. M., Doyle, M. F., Elliott, P., Floyd, J. S., Fuchsberger, C., Grarup, N., Guo, X., Harris, S., Hou, L., Kolcic, I., Kooperberg, C., Menni, C., Nauck, M., O'Connell, J. R., Orru, V., Psaty, B. M., Räikkönen, K., Smith, J. A., Soria, J. M., Stott, D., van Hylckama Vlieg, A., Watkins, H., Willemsen, G., Wilson, P. W., Ben-Shlomo, Y., Blangero, J., Boomsma, D., Cox, S. R., Dehghan, A., Eriksson, J. G., Fiorillo, E., Fornage, M., Hansen, T., Hayward, C., Ikram, M. A., Jukema, J. W., Kardia, S., Lange, L., Maerz, W., Mathias, R., Mitchell, B. D., Mook-Kanamori, D. O., Morange, P-E., Pedersen, O., Pramstaller, P. P., Redline, S., Reiner, A. P., Ridker, P. M., Silverman, E. K., Spector, T. D., Volker, U., Wareham, N., Wilson, J., Yao, J., Tregouet, D-A., Johnson, A. D., Wolberg, A. S., de Vries, P. S., Sabater-Lleal, M., Morrison, A. & Smith, N. L., 2024, In: Blood. 144, 21, p. 2248–2265

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)
• 2023

  Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss

  Christiansen, M. R., Kilpelöainen, T. O. & McCaffery, J. M., 2023, In: Diabetes. 72, 10, p. 1424-1432 9 p.

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• Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

  de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C. Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A., Kolčić, I. & 178 others, Lim, E., Liu, Y., Manning, A. K., Marten, J., Musani, S. K., Noordam, R., Padmanabhan, S., Rankinen, T., Richard, M. A., Ridker, P. M., Smith, A. V., Vojinovic, D., Zonderman, A. B., Alver, M., Boissel, M., Christensen, K., Freedman, B. I., Gao, C., Giulianini, F., Harris, S. E., He, M., Hsu, F. C., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L. P., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Robino, A., Sofer, T., Takeuchi, F., Tayo, B. O., van der Most, P. J., Verweij, N., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhan, Y., Amin, N., Arking, D. E., Ballantyne, C., Boerwinkle, E., Brody, J. A., Broeckel, U., Campbell, A., Canouil, M., Chai, X., Chen, Y. D. I., Chen, X., Chitrala, K. N., Concas, M. P., de Faire, U., de Mutsert, R., de Silva, H. J., de Vries, P. S., Do, A., Faul, J. D., Fisher, V., Floyd, J. S., Forrester, T., Friedlander, Y., Girotto, G., Gu, C. C., Hallmans, G., Heikkinen, S., Heng, C. K., Homuth, G., Hunt, S., Ikram, M. A., Jacobs, D. R., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Komulainen, P., Langefeld, C. D., Liang, J., Liu, K., Liu, J., Lohman, K., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Milaneschi, Y., Nauck, M., Nelson, C. P., O’Connell, J. R., Palmer, N. D., Pereira, A. C., Perls, T., Peters, A., Polašek, O., Raitakari, O. T., Rice, K., Rice, T. K., Rich, S. S., Sabanayagam, C., Schreiner, P. J., Shu, X. O., Sidney, S., Sims, M., Smith, J. A., Starr, J. M., Strauch, K., Tai, E. S., Taylor, K. D., Tsai, M. Y., Uitterlinden, A. G., van Heemst, D., Waldenberger, M., Wang, Y. X., Wei, W. B., Wilson, G., Xuan, D., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Becker, D. M., Bonnefond, A., Bowden, D. W., Cooper, R. S., Deary, I. J., Divers, J., Esko, T., Franks, P. W., Froguel, P., Gieger, C., Jonas, J. B., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., North, K. E., Ntalla, I., Penninx, B., Samani, N. J., Snieder, H., Spedicati, B., van der Harst, P., Völzke, H., Wagenknecht, L. E., Weir, D. R., Wojczynski, M. K., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Chasman, D. I., Evans, M. K., Fox, E. R., Gudnason, V., Hayward, C., Horta, B. L., Kardia, S. L. R., Krieger, J. E., Mook-Kanamori, D. O., Peyser, P. A., Province, M. M., Psaty, B. M., Rudan, I., Sim, X., Smith, B. H., van Dam, R. M., van Duijn, C. M., Wong, T. Y., Arnett, D. K., Rao, D. C., Gauderman, J., Liu, C. T., Morrison, A. C., Rotter, J. I. & Fornage, M., 2023, In: Frontiers in Genetics. 14, 16 p., 1235337.

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• Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

  Drag, M. H., Debes, K. P., Franck, C. S., Flethøj, M., Lyhne, M. K., Møller, J. E., Ludvigsen, T. P., Jespersen, T., Olsen, L. H. & Kilpeläinen, T. O., 2023, In: Epigenetics. 18, 1, 17 p., 2199374.

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  4 Citations (Scopus)

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• Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles

  Huffman, J. E., Nicolas, J., Hahn, J., Heath, A. S., Raffield, L. M., Yanek, L. R., Brody, J. A., Thibord, F., Almasy, L., Bartz, T. M., Bielak, L. F., Bowler, R. P., Carrasquilla, G. D., Chasman, D. I., Chen, M-H., Emmert, D. B., Ghanbari, M., Haessle, J., Hottenga, J-J., Kleber, M. E. & 31 others, Le, N-Q., Lee, J., Lewis, J. P., Li-Gao, R., Luan, J., Malmberg, A., Mangino, M., Marioni, R. E., Martinez-Perez, A., Pankratz, N., Polasek, O., Richmond, A., Rodriguez, B. A., Rotter, J. I., Steri, M., Suchon, P., Trompet, S., Weiss, S., Zare, M., Auer, P., Cho, M. H., Christofidou, P., Davies, G., de Geus, E., Deleuze, J-F., Kilpeläinen, T. O., Linneberg, A., Grarup, N., Hansen, T., Pedersen, O. & VA Million Veteran Program, 2023, medRxiv, 20 p.

  Research output: Working paper › Preprint
• 2022

  Association of milk intake with hay fever, asthma, and lung function: a Mendelian randomization analysis

  Skaaby, T., Kilpeläinen, T. O., Mahendran, Y., Huang, L. O., Sallis, H., Thuesen, B. H., Kårhus, L. L., Leth-Møller, K. B., Grarup, N., Hansen, T., Pedersen, O., Burgess, S., Munafò, M. R. & Linneberg, A., 2022, In: European Journal of Epidemiology. 37, p. 713-722

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  3 Citations (Scopus)

• Causality between physical activity, sedentary behavior and obesity: A Mendelian randomization study

  Carrasquilla, G. D., Garcia-Urena, M., Fall, T., Sorensen, T. I. A. & Kilpelainen, T. O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 536-536 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Changes in BMI and physical activity from youth to adulthood distinguish normal-weight, metabolically obese adults from those who remain healthy

  Viitasalo, A., Pahkala, K., Lehtimäki, T., Viikari, J. S. A., Tammelin, T. H., Raitakari, O. & Kilpeläinen, T. O., 2022, In: Frontiers in Endocrinology. 13, 7 p., 923327.

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• Do gene-environment interactions have implications for the precision prevention of type 2 diabetes?

  Sørensen, T. I. A., Metz, S. & Kilpeläinen, T. O., 2022, In: Diabetologia. 65, p. 1804–1813 10 p.

  Research output: Contribution to journal › Review › Research › peer-review

• Estimating the causal relationship between smoking and abdominal adiposity using Mendelian randomization

  Carrasquilla, G. D., García-Ureña, M., Sharma, S. & Kilpeläinen, T. O., 2022, Cold Spring Harbor Laboratory, (bioRxiv).

  Research output: Working paper › Preprint

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• Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention

  McCaffery, J. M., Jablonski, K. A., Pan, Q., Astrup, A., Revsbech Christiansen, M., Corella, D., Corso, L. M. L., Florez, J. C., Franks, P. W., Gardner, C., Hansen, T., Kilpeläinen, T. O., Knowler, W. C., Lindström, J., Saris, W. H. M., Sørensen, T. I. A., Tuomilehto, J., Uusitupa, M., Wing, R. R. & Agurs-Collins, T., 2022, In: Diabetes. 71, 4, p. 669-676 8 p.

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  7 Citations (Scopus)

• Genetic studies indicate that fetal - and not maternal - insulin resistance is associated with birth weight

  Jakupovic, H., Urena, M. G., Sørensen, T. I. A. & Kilpelainen, T. O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 592-593 2 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

  Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, Gieger, C., Graff, M., Hall, L. M., Haller, T., Hartwig, F. P., Hillis, D. A., Huikari, V., Heard-Costa, N., Holzapfel, C., Jackson, A. U., Johansson, A., Jorgensen, A. M., Kaakinen, M. A., Karlsson, R., Kerr, K. F., Kim, B., Koolhaas, C. M., Kutalik, Z., Pacolet, A., Zhao, J-H., Balslev-Harder, M. N., Grarup, N., Linneberg, A., Hansen, T., Melbye, M., Pedersen, O., Pers, T. H., Sorensen, T. I. A., Zierath, J. R., Oskari Kilpeläinen, T., Loos, R. J. F. & LifeLines Cohort Study, 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.

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• Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk

  Leppanen, M. H., Haapala, E. A., Vaisto, J., Ekelund, U., Brage, S., Kilpeläinen, T. O. & Lakka, T. A., 2022, In: Scandinavian Journal of Medicine & Science in Sports. 32, 1, p. 255-266

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  16 Citations (Scopus)

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• Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity

  Carrasquilla, G. D., García-Ureña, M., Fall, T., Sørensen, T. IA. & Kilpeläinen, T., 2022, In: eLife. 11, 25 p., e70386.

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• Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and obesity

  Carrasquilla, G. D., García-Ureña, M., Fall, T., Sørensen, T. I. A. & Kilpeläinen, T. O., 2022, (bioRxiv).

  Research output: Working paper › Research

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• Mendelian randomization suggests a causal effect of abdominal obesity on postprandial lipemia

  Christiansen, M. R., Hansen, T., Sorensen, T. I. A., Grarup, N., Urena, M. G., Borisevich, D., Oppert, J-M., Martinez Hernandez, J. A., Blaak, E. & Kilpelainen, T. O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 184 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
  7 Citations (Scopus)

• The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism

  Metz, S., Krarup, N. T., Bryrup, T., Støy, J., Andersson, E. A., Christoffersen, C., Neville, M. J., Christiansen, M. R., Jonsson, A. E., Witte, D. R., Kampmann, U., Nielsen, L. B., Jørgensen, N. R., Karpe, F., Grarup, N., Pedersen, O., Kilpeläinen, T. O. & Hansen, T., 2022, In: Journal of the Endocrine Society. 6, 5, 10 p., bvac034.

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• With obesity becoming the new normal, what should we do? Volume II

  Tziomalos, K., Kilpeläinen, T. O. & Samaras, K., 2022, In: Frontiers in Endocrinology. 13, 3 p., 1119910.

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• 2021

  Abdominal and gluteofemoral fat depots show opposing associations with postprandial lipemia

  Christiansen, M. R., Ureña, M. G., Borisevich, D., Grarup, N., Martínez, J. A., Oppert, J-M., Sørensen, T. I. A., Hansen, T., Blaak, E. E. & Kilpeläinen, T. O., 2021, In: American Journal of Clinical Nutrition. 114, 4, p. 1467–1475 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Cell-free DNA and RNA - measurement and applications in clinical diagnostics with focus on metabolic disorders

  Drag, M. H. & Kilpeläinen, T. O., 2021, In: Physiological Genomics. 53, 1, p. 33-46

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  28 Citations (Scopus)

• Changes in intake of dairy product subgroups and risk of type 2 diabetes: modelling specified food substitutions in the Danish Diet, Cancer and Health cohort

  Ibsen, D. B., Overvad, K., Laursen, A. S. D., Halkjær, J., Tjønneland, A., Kilpeläinen, T. O., Parner, E. T. & Jakobsen, M. U., 2021, In: European Journal of Nutrition. 60, p. 3449–3459 11 p.

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• Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

  Sulc, J., Sonrel, A., Mounier, N., Auwerx, C., Marouli, E., Darrous, L., Draganski, B., Kilpeläinen, T. O., Joshi, P., Loos, R. J. F. & Kutalik, Z., 2021, In: Communications Biology . 4, 13 p., 1064.

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• Do genetic risk scores for childhood adiposity operate independent of BMI of their mothers?

  Huang, L. O., Morgen, C. S., Angquist, L., Nohr, E. A., Kilpelainen, T. O., Hansen, T., Sorensen, T. I. A. & Schnurr, T. M., 2021, In: International Journal of Obesity. 45, 10 p.

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• Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health

  Williams, K., Carrasquilla, G. D., Ingerslev, L. R., Hochreuter, M. Y., Hansson, S., Pillon, N. J., Donkin, I., Versteyhe, S., Zierath, J. R., Kilpeläinen, T. O. & Barrès, R., 2021, In: Molecular Metabolism. 53, 13 p., 101290.

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  16 Citations (Scopus)

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• Evidence for shared genetics between physical activity, sedentary behaviour and adiposity-related traits

  Schnurr, T. M., Stallknecht, B. M., Sørensen, T. I. A., Kilpelainen, T. O. & Hansen, T., 2021, In: Obesity Reviews. 22, 4, 12 p., e13182.

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  16 Citations (Scopus)

• FGL1 as a modulator of plasma D-dimer levels: exome-wide marker analysis of plasma tPA, PAI-1 and D-dimer

  Thibord, F., Song, C., Pattee, J., Rodriguez, B. A. T., Chen, M-H., O'Donnell, C. J., Kleber, M. E., Delgado, G. E., Guo, X., Yao, J., Taylor, K. D., Ozel, A. B., Brody, J. A., McKnight, B., Gyorgy, B., Simonsick, E., Leonard, H. L., Carrasquilla, G. D., Guindo-Martinez, M., Silveira, A. & 30 others, Temprano-Sagrera, G., Yanek, L. R., Becker, D. M., Mathias, R. A., Becker, L. C., Raffield, L. M., Kilpeläinen, T. O., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Hamsten, A., Watkins, H., Sabater-Lleal, M., Nalls, M. A., Trégouët, D-A., Morange, P-E., Psaty, B. M., Tracy, R. P., Smith, N. L., Desch, K. C., Cushman, M., Rotter, J. I., de Vries, P. S., Pankratz, N. D., Folsom, A. R., Morrison, A. C., März, W., Tang, W. & Johnson, A. D., 2021, In: Journal of Thrombosis and Haemostasis. 19, 8, p. 2019-2028

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

  de Las Fuentes, L., Sung, Y. J., Noordam, R., Winkler, T., Feitosa, M. F., Schwander, K., Bentley, A. R., Brown, M. R., Guo, X., Manning, A., Chasman, D. I., Aschard, H., Bartz, T. M., Bielak, L. F., Campbell, A., Cheng, C-Y., Dorajoo, R., Hartwig, F. P., Horimoto, A. R. V. R., Li, C. & 31 others, Li-Gao, R., Liu, Y., Marten, J., Musani, S. K., Ntalla, I., Rankinen, T., Richard, M., Sim, X., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Vojinovic, D., Warren, H. R., Xuan, D., Alver, M., Boissel, M., Chai, J-F., Chen, X., Christensen, K., Divers, J., Evangelou, E., Gao, C., Girotto, G., Harris, S. E., He, M., Hsu, F-C., Kühnel, B., Laguzzi, F., Li, X., Kilpeläinen, T. O. & LifeLines Cohort Study, 2021, In: Molecular Psychiatry. 26, p. 2111-2125

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  18 Citations (Scopus)

• Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

  Huang, L. O., Rauch, A., Mazzaferro, E., Preuss, M., Carobbio, S., Bayrak, C. S., Chami, N., Wang, Z., Schick, U. M., Yang, N., Itan, Y., Vidal-Puig, A., den Hoed, M., Mandrup, S., Kilpeläinen, T. O. & Loos, R. J. F., 2021, In: Nature Metabolism. 3, 2, p. 228-243 16 p.

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  73 Citations (Scopus)

• Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

  LifeLines Cohort Study, 2021, In: Human Genetics and Genomics Advances. 2, 1, 12 p., 100013.

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• Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

  Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpeläinen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., Liu, Y. & 105 others, Chitrala, K., Rankinen, T., Musani, S. K., Franceschini, N., Rauramaa, R., Alver, M., Zee, P. C., Harris, S. E., van der Most, P. J., Nolte, I. M., Munroe, P. B., Palmer, N. D., Kühnel, B., Weiss, S., Wen, W., Hall, K. A., Lyytikäinen, L-P., O'Connell, J., Eiriksdottir, G., Launer, L. J., de Vries, P. S., Arking, D. E., Chen, H., Boerwinkle, E., Krieger, J. E., Schreiner, P. J., Sidney, S., Shikany, J. M., Rice, K., Chen, Y-D. I., Gharib, S. A., Bis, J. C., Luik, A. I., Ikram, M. A., Uitterlinden, A. G., Amin, N., Xu, H., Levy, D., He, J., Lohman, K. K., Zonderman, A. B., Rice, T. K., Sims, M., Wilson, G., Sofer, T., Rich, S. S., Palmas, W., Yao, J., Guo, X., Rotter, J. I., Biermasz, N. R., Mook-Kanamori, D. O., Martin, L. W., Barac, A., Wallace, R. B., Gottlieb, D. J., Komulainen, P., Heikkinen, S., Mägi, R., Milani, L., Metspalu, A., Starr, J. M., Milaneschi, Y., Waken, R. J., Gao, C., Waldenberger, M., Peters, A., Strauch, K., Meitinger, T., Roenneberg, T., Völker, U., Dörr, M., Shu, X-O., Mukherjee, S., Hillman, D. R., Kähönen, M., Wagenknecht, L. E., Gieger, C., Grabe, H. J., Zheng, W., Palmer, L. J., Lehtimäki, T., Gudnason, V., Morrison, A. C., Pereira, A. C., Fornage, M., Psaty, B. M., van Duijn, C. M., Liu, C-T., Kelly, T. N., Evans, M. K., Bouchard, C., Fox, E. R., Kooperberg, C., Zhu, X., Lakka, T. A., Esko, T., North, K. E., Deary, I. J., Snieder, H., Penninx, B. W. J. H., Gauderman, W. J., Rao, D. C., Redline, S. & van Heemst, D., 2021, In: Molecular Psychiatry. 26, p. 6293-6304

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• Replacing Red Meat with Other Nonmeat Food Sources of Protein is Associated with a Reduced Risk of Type 2 Diabetes in a Danish Cohort of Middle-Aged Adults

  Ibsen, D. B., Jakobsen, M. U., Halkjær, J., Tjønneland, A., Kilpeläinen, T. O., Parner, E. T. & Overvad, K., 2021, In: The Journal of Nutrition. 151, 5, p. 1241-1248 8 p.

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  13 Citations (Scopus)

• The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children: the PANIC Study

  Eloranta, A-M., Sallinen, T., Viitasalo, A., Lintu, N., Väistö, J., Jalkanen, H., Tompuri, T. T., Soininen, S., Haapala, E. A., Kiiskinen, S., Schnurr, T. M., Kilpeläinen, T. O., Mikkonen, S., Savonen, K., Atalay, M., Brage, S., Laaksonen, D. E., Lindi, V., Ågren, J., Schwab, U. & 2 others, Jääskeläinen, J. & Lakka, T. A., 2021, In: European Journal of Nutrition. 60, p. 425-434

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• The Genetic Basis of Hypertriglyceridemia

  Carrasquilla, G. D., Christiansen, M. R. & Kilpeläinen, T. O., 2021, In: Current Atherosclerosis Reports. 23, 10 p., 39.

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• 2020

  A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study

  Lakka, T. A., Lintu, N., Väistö, J., Viitasalo, A., Sallinen, T., Haapala, E. A., Tompuri, T. T., Soininen, S., Karjalainen, P., Schnurr, T. M., Mikkonen, S., Atalay, M., Kilpeläinen, T. O., Laitinen, T., Laaksonen, D. E., Savonen, K., Brage, S., Schwab, U., Jääskeläinen, J., Lindi, V. & 1 others, Eloranta, A-M., 2020, In: Diabetologia. 63, p. 2270-2281

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• From man to mouse: The discovery and validation of CYR61 as a regulator of body composition

  Metz, S., Grevengoed, T. J., Kilpelainen, T. O. & Gillum, M. P., 2020, In: European Journal of Human Genetics. 28, SUPPL 1, p. 741-742 1 p.

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• Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

  Yaghootkar, H., Zhang, Y., Spracklen, C. N., Karaderi, T., Huang, L. O., Bradfield, J., Schurmann, C., Fine, R. S., Preuss, M. H., Kutalik, Z., Wittemans, L. B., Lu, Y., Metz, S., Willems, S. M., Li-Gao, R., Grarup, N., Wang, S., Molnos, S., Sandoval-Zárate, A. A., Nalls, M. A. & 32 others, Lange, L. A., Haesser, J., Guo, X., Lyytikäinen, L-P., Feitosa, M. F., Sitlani, C. M., Venturini, C., Mahajan, A., Kacprowski, T., Wang, C. A., Chasman, D. I., Amin, N., Broer, L., Robertson, N., Young, K. L., Allison, M., Auer, P. L., Blüher, M., Borja, J. B., Bork-Jensen, J., Carrasquilla, G. D., Christofidou, P., Demirkan, A., Doege, C. A., Jakupovic, H., Li, J., Lind, L., Kovacs, P., Hansen, T., Loos, R. JF., Kilpeläinen, T. O. & Leptin Exomechip Collaboration, 2020, In: Diabetes. 69, 11, 93 p.

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• Genetic variation, adipokines, and cardiometabolic disease

  Metz, S., Huang, L. O. & Kilpeläinen, T. O., 2020, In: Current Opinion in Pharmacology. 52, p. 33-39 7 p.

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  7 Citations (Scopus)

• Impact of abdominal obesity on postprandial lipid concentrations

  Christiansen, M. R., Sørensen, T. I. A., Hansen, T. & Kilpelainen, T. O., 2020, In: European Journal of Human Genetics. 28, Suppl. 1, p. 279-280 2 p.

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  4 Citations (Scopus)

• Increase in adiposity from childhood to adulthood predicts a metabolically obese phenotype in normal-weight adults

  Viitasalo, A., Pitkänen, N., Pahkala, K., Lehtimäki, T., Viikari, J. S. A., Raitakari, O. & Kilpeläinen, T. O., 2020, In: International Journal of Obesity. 44, p. 848-851

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  8 Citations (Scopus)

• Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

  Zheng, Y., Huang, T., Wang, T., Mei, Z., Sun, Z., Zhang, T., Ellervik, C., Chai, J-F., Sim, X., van Dam, R. M., Tai, E-S., Koh, W-P., Dorajoo, R., Saw, S-M., Sabanayagam, C., Wong, T. Y., Gupta, P., Rossing, P., Ahluwalia, T. S., Vinding, R. K. & 98 others, Bisgaard, H., Bønnelykke, K., Wang, Y., Graff, M., Voortman, T., van Rooij, F. J. A., Hofman, A., van Heemst, D., Noordam, R., Estampador, A. C., Varga, T. V., Enzenbach, C., Scholz, M., Thiery, J., Burkhardt, R., Orho-Melander, M., Schulz, C-A., Ericson, U., Sonestedt, E., Kubo, M., Akiyama, M., Zhou, A., Kilpeläinen, T. O., Hansen, T., Kleber, M. E., Delgado, G., McCarthy, M., Lemaitre, R. N., Felix, J. F., Jaddoe, V. W. V., Wu, Y., Mohlke, K. L., Lehtimäki, T., Wang, C. A., Pennell, C. E., Schunkert, H., Kessler, T., Zeng, L., Willenborg, C., Peters, A., Lieb, W., Grote, V., Rzehak, P., Koletzko, B., Erdmann, J., Munz, M., Wu, T., He, M., Yu, C., Lecoeur, C., Froguel, P., Corella, D., Moreno, L. A., Lai, C-Q., Pitkänen, N., Boreham, C. A., Ridker, P. M., Rosendaal, F. R., de Mutsert, R., Power, C., Paternoster, L., Sørensen, T. I. A., Tjønneland, A., Overvad, K., Djousse, L., Rivadeneira, F., Lee, N. R., Raitakari, O. T., Kähönen, M., Viikari, J., Langhendries, J-P., Escribano, J., Verduci, E., Dedoussis, G., König, I., Balkau, B., Coltell, O., Dallongeville, J., Meirhaeghe, A., Amouyel, P., Gottrand, F., Pahkala, K., Niinikoski, H., Hyppönen, E., März, W., Mackey, D. A., Gruszfeld, D., Tucker, K. L., Fumeron, F., Estruch, R., Ordovas, J. M., Arnett, D. K., Mook-Kanamori, D. O., Mozaffarian, D., Psaty, B. M., North, K. E., Chasman, D. I. & Qi, L., 2020, In: European Journal of Epidemiology. 35, p. 685–697 13 p.

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  8 Citations (Scopus)

• Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

  Schnurr, T. M., Jakupovic, H., Carrasquilla, G. D., angquist, L., Grarup, N., Sorensen, T. I. A., Tjønneland, A., Overvad, K., Pedersen, O., Hansen, T. & Kilpelainen, T. O., 2020, In: Diabetologia. 63, 7, p. 1324-1332 9 p.

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  140 Citations (Scopus)
• 2019

  Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis

  Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., Atalay, M., Lind, M. V., Heikkinen, S., Frithioff-Bøjsøe, C., Fonvig, C. E., Grarup, N., Kähönen, M., Carrasquilla, G. D., Larnkjær, A., Pedersen, O., Michaelsen, K. F., Lakka, T. A., Holm, J-C., Lehtimäki, T. & 3 others, Raitakari, O., Hansen, T. & Kilpeläinen, T. O., 2019, In: American Journal of Clinical Nutrition. 110, 5, p. 1079-1087 9 p.

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• A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

  Sung, Y. J., de Las Fuentes, L., Winkler, T. W., Chasman, D. I., Bentley, A. R., Kraja, A. T., Ntalla, I., Warren, H. R., Guo, X., Schwander, K., Manning, A. K., Brown, M. R., Aschard, H., Feitosa, M. F., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Marten, J. & 263 others, Musani, S. K., Kilpelainen, T. O., Richard, M. A., Aslibekyan, S., Bartz, T. M., Dorajoo, R., Li, C., Liu, Y., Rankinen, T., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Zhao, W., Zhou, Y., Matoba, N., Sofer, T., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Giulianini, F., Goel, A., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F-C., Jackson, A. U., Kammerer, C. M., Kasturiratne, A., Komulainen, P., Kuehnel, B., Leander, K., Lee, W-J., Lin, K-H., Luan, J., Lyytikainen, L-P., McKenzie, C. A., Nelson, C. P., Noordam, R., Scott, R. A., Sheu, W. H. H., Stancakova, A., Takeuchi, F., van Der Most, P. J., Varga, T. V., Waken, R. J., Wang, H., Wang, Y., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhang, W., Zhao, J. H., Afaq, S., Alfred, T., Amin, N., Arking, D. E., Aung, T., Barr, R. G., Bielak, L. F., Boerwinkle, E., Bottinger, E. P., Braund, P. S., Brody, J. A., Broeckel, U., Cade, B., Campbell, A., Canouil, M., Chakravarti, A., Cocca, M., Collins, F. S., Connell, J. M., de Mutsert, R., de Silva, H. J., Doerr, M., Duan, Q., Eaton, C. B., Ehret, G., Evangelou, E., Faul, J. D., Forouhi, N. G., Franco, O. H., Friedlander, Y., Gao, H., Gigante, B., Gu, C. C., Gupta, P., Hagenaars, S. P., Harris, T. B., He, J., Heikkinen, S., Heng, C-K., Hofman, A., Howard, B. V., Hunt, S. C., Irvin, M. R., Jia, Y., Katsuya, T., Kaufman, J., Kerrison, N. D., Khor, C. C., Koh, W-P., Koistinen, H. A., Kooperberg, C. B., Krieger, J. E., Kubo, M., Kutalik, Z., Kuusisto, J., Lakka, T. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. H., Lehne, B., Levy, D., Lewis, C. E., Li, Y., Lim, S. H., Liu, C-T., Liu, J., Liu, J., Liu, Y., Loh, M., Lohman, K. K., Louie, T., Magi, R., Matsuda, K., Meitinger, T., Metspalu, A., Milani, L., Momozawa, Y., Mosley, T. H. . J., Nalls, M. A., Nasri, U., O'Connell, J. R., Ogunniyi, A., Palmas, W. R., Palmer, N. D., Pankow, J. S., Pedersen, N. L., Peters, A., Peyser, P. A., Polasek, O., Porteous, D., Raitakari, O. T., Renstrom, F., Rice, T. K., Ridker, P. M., Robino, A., Robinson, J. G., Rose, L. M., Rudan, I., Sabanayagam, C., Salako, B. L., Sandow, K., Schmidt, C. O., Schreiner, P. J., Scott, W. R., Sever, P., Sims, M., Sitlani, C. M., Smith, B. H., Smith, J. A., Snieder, H., Starr, J. M., Strauch, K., Tang, H., Taylor, K. D., Teo, Y. Y., Tham, Y. C., Uitterlinden, A. G., Waldenberger, M., Wang, L., Wang, Y. X., Wei, W. B., Wilson, G., Wojczynski, M. K., Xiang, Y-B., Yao, J., Yu, C., Yuan, J-M., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., Chambers, J. C., Chen, Y-D. I., Weir, D. R., de Faire, U., Deary, I. J., Esko, T., Farrall, M., Forrester, T., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Horta, B. L., Hung, Y-J., Jonas, J. B., Kato, N., Kooner, J. S., Laakso, M., Lehtimaki, T., Liang, K-W., Magnusson, P. K. E., Oldehinkel, A. J., Pereira, A. C., Perls, T., Rauramaa, R., Redline, S., Rettig, R., Samani, N. J., Scott, J., Shu, X-O., van Der Harst, P., Wagenknecht, L. E., Wareham, N. J., Watkins, H., Wickremasinghe, A. R., Wu, T., Kamatani, Y., Laurie, C. C., Bouchard, C., Cooper, R. S., Evans, M. K., Gudnason, V., Hixson, J., Kardia, S. L. R., Kritchevsky, S. B., Psaty, B. M., van Dam, R. M., Arnett, D. K., Mook-Kanamori, D. O., Fornage, M., Fox, E. R., Hayward, C., van Duijn, C. M., Tai, E. S., Wong, T. Y., Loos, R. J. F., Reiner, A. P., Rotimi, C. N., Bierut, L. J., Zhu, X., Cupples, L. A., Province, M. A., Rotter, J. I., Franks, P. W., Rice, K., Elliott, P., Caulfield, M. J., Gauderman, W. J., Munroe, P. B., Rao, D. C., Morrison, A. C. & Oskari Kilpeläinen, T., 1 Aug 2019, In: Human Molecular Genetics. 28, 15, p. 2615-2633

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