Uffe Kristiansen

Search results

• 2002

  Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA_A antagonists: Synthesis, pharmacology, and molecular modeling

  Frølund, B., Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, U., Sanchez, C., Krogsgaard-Larsen, P. & Liljefors, T., 6 Jun 2002, In: Journal of Medicinal Chemistry. 45, 12, p. 2454-2468 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  138 Citations (Scopus)

• Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABA_A Antagonists:Synthesis, Pharmacology, and Molecular Modeling

  Frølund, B., Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, U., Sanchez, C., Krogsgaard-Larsen, P. & Liljefors, T., 2002, In: Journal of Medicinal Chemistry. 45, p. 2454–2468

  Research output: Contribution to journal › Journal article › Research › peer-review

• Point mutation in the first transmembrane region of the β2 subunit of the γ-aminobutyric acid type A receptor alters desensitization kinetics of γ-aminobutyric acid- and anesthetic-induced channel gating

  Christine Engblom, A., Carlson, B. X., Olsen, R. W., Schousboe, A. & Kristiansen, U., 17 May 2002, In: Journal of Biological Chemistry. 277, 20, p. 17438-17447 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  18 Citations (Scopus)
• 2001

  Effects of GABA_A receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions

  Hansen, S. L., Ebert, B., Fjalland, B. & Kristiansen, U., 2001, In: British Journal of Pharmacology. 133, 4, p. 539-549 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Ligands for the GABA_A receptor complex

  Krogsgaard-Larsen, P., Frølund, B., Kristiansen, U. & Ebert, B., 1 Jan 2001, Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press, p. 236-274 39 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  15 Citations (Scopus)

• Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2

  Elster, L., Kristiansen, U., Pickering, D. S., Olsen, R. W. & Schousboe, A., 2001, In: Neurochemistry International. 38, 7, p. 581-92 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  1 Citation (Scopus)
• 2000

  A novel class of potent 3-isoxazolol GABA_A antagonists: Design, systhesis, and pharmacology [3]

  Frølund, B., Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, U. & Krogsgaard-Larsen, P., 28 Dec 2000, In: Journal of Medicinal Chemistry. 43, 26, p. 4930-4933 4 p.

  Research output: Contribution to journal › Letter › Research › peer-review
  42 Citations (Scopus)

• A Novel Class of Potent 3-Isoxazolol GABA_A Antagonists: Design, Synthesis, and Pharmacology

  Frølund, B., Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, U. & Krogsgaard-Larsen, P., 2000, In: Journal of Medicinal Chemistry. 43, p. 4930–4933

  Research output: Contribution to journal › Journal article › Research › peer-review

• A single glycine residue at the entrance to the first membrane-spanning domain of the γ-aminobutyric acid type a receptor β₂ subunit affects allosteric sensitivity to GABA and anesthetics

  Carlson, B. X., Engblom, A. C., Kristiansen, U., Schousboe, A. & Olsen, R. W., 2000, In: Molecular Pharmacology. 57, 3, p. 474-484 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  62 Citations (Scopus)
• 1998

  Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells

  Elster, L., Banke, T., Kristiansen, U., Schousboe, A. & Wahl, P., May 1998, In: Neuroscience. 84, 2, p. 519-28 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 1997

  GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: Design and therapeutic prospects

  Krogsgaard-Larsen, P., Frølund, B., Kristiansen, U., Frydenvang, K. & Ebert, B., Nov 1997, In: European Journal of Pharmaceutical Sciences. 5, 6, p. 355-384 30 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)

• GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects

  Frølund, B., Krogsgaard-Larsen, P., Kristiansen, U., Frydenvang, K. A. & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384

  Research output: Contribution to journal › Journal article › Research › peer-review

• Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors

  Brehm, L., Ebert, B., Kristiansen, U., Wafford, K. A., Kemp, J. A. & Krogsgaard-Larsen, P., 1997, In: European Journal of Medicinal Chemistry. 32, 4, p. 357-363 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)
• 1996

  Benzodiazepine and barbiturate ligands modulate responses of cultured hippocampal neurones to the GABA(A) receptor partial agonist, 4-PIOL

  Kristiansen, U. & Lambert, J. D. C., 1996, In: Neuropharmacology. 35, 9-10, p. 1181-1191 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Stereospecific GABA-B receptor antagonism

  Frydenvang, K. A., Frølund, B., Kristiansen, U. & Krogsgaard-Larsen, P., 1996, GABA, receptors, transporters and metabolism. Tanaka, C. & Bowery, N. G. (eds.). Basel: Birkhäuser Verlag

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 1995

  GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer

  Frydenvang, K. A., Kristiansen, U., Frølund, B., Herdeis, C. & Krogsgaard-Larsen, P., 1995, In: Chirality. 7, p. 526–533

  Research output: Contribution to journal › Journal article › Research › peer-review

  3 Citations (Scopus)

• Partial GABA_A Receptor agonists. Synthesis and in vitro Pharmacology

  Frølund, B., Kristiansen, U., Brehm, L., Hansen, A. B., Krogsgaard-Larsen, P. & Falch, E., 1995, In: Journal of Medicinal Chemistry. 38, p. 3287–3296

  Research output: Contribution to journal › Journal article › Research › peer-review

• Partial GABA_A Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol

  Frølund, B., Kristiansen, U., Brehm, L., Hansen, A. B., Krogsgaard-Larsen, P. & Falch, E., 1 Aug 1995, In: Journal of Medicinal Chemistry. 38, 17, p. 3287-3296 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  69 Citations (Scopus)

• The low efficacy γ-aminobutyric acid type A agonist 5-(4- piperidyl)isoxazol-3-ol opens brief Cl^- channels in embryonic rat olfactory bulb neurons

  Kristiansen, U., Barker, J. L. & Serafini, R., 1995, In: Molecular Pharmacology. 48, 2, p. 268-279 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  9 Citations (Scopus)
• 1992

  Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships

  Kristiansen, U., Hedegaard, A., Herdeis, C., Lund, T. M., Nielsen, B., Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, P., Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)
• 1991

  4-PIOL, a low-efficacy partial GABA-A agonist

  Frølund, B., Kristiansen, U., Nathan, T., Falch, E., Lambert, J. D. C. & Krogsgaard-Larsen, P., 1991, Drug Research related to Neuroactive Amino Acids. Munksgaard

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Electrophysiological studies of the GABA_A receptor ligand, 4‐PIOL, on cultured hippocampal neurones

  Kristiansen, U., Lambert, J. D. C., Falch, E. & Krogsgaard‐Larsen, P., Sep 1991, In: British Journal of Pharmacology. 104, 1, p. 85-90 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  42 Citations (Scopus)

• Ligand Structural Specificity of GABA_A Receptors in Guinea Pig Ileum

  Kristiansen, U. & Fjalland, B., May 1991, In: Pharmacology & Toxicology. 68, 5, p. 332-339 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Novel (Gamma-Aminobutyric Acid)_A Agonists and Partial Agonists

  Krogsgaard-Larsen, P., Frølund, B., Kristiansen, U., Lambert, J. D. C., Falch, E. & Curtis, D. R., 1991, Transmitter Amino Acid Receptors. Barnard, E. A. & Costa, E. (eds.). Raven Press, p. 237–249

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review