Ulla M. Wewer

Research output

Research output per year 1980 1986 1988 1994 1996 1997 1998 2000 2002 2003 2005 2006 2008 2018

• 13405 Citations
• 163 Journal article
• 2 Review
• 1 Book
• 1 Book chapter
• 2 More
  • 1 Contribution to newspaper - Comment/debate
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2018

  Personlig medicin vil involvere alle specialer, og det handler om andet end genomet

  Ullum, H., Hersom, C., Wewer, U., Skøtt, O., Nielsen, L. B. & Rasmussen, L. H., 2018, In: Ugeskrift for Laeger. 180, 6, p. 501 1 p.

  Research output: Contribution to journal › Editorial › Research
• 2017

  Corporate culture: research can benefit

  Westendorp, R. G. J. & Wewer, U., 2017, In: Nature. 542, 7641, 1 p., 295.

  Research output: Contribution to journal › Journal article › Communication
• 2016

  The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour

  Høye, A. M., Couchman, J. R., Wewer, U. M. & Yoneda, A., 2016, In: Scientific Reports. 6, 14 p., 28529.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  182 Downloads (Pure)
• 2013

  ADAM12

  Kveiborg, M., Fröhlich, C., Albrechtsen, R. & Wewer, U. M., 29 Aug 2013, Handbook of Proteolytic Enzymes. Elsevier, Vol. 1. p. 1114-1122 9 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins

  Frohlich, C., Klitgaard, M., Noer, J. B., Kotzsch, A., Nehammer, C., Kronqvist, P., Berthelsen, J., Blobel, C., Kveiborg, M., Albrechtsen, R. & Wewer, U. M., 15 May 2013, In: Biochemical Journal. 452, 1, p. 97-109 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  47 Citations (Scopus)

• ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth

  Albrechtsen, R., Kveiborg, M., Hansen, D. S., Vikeså, J., Noer, J. B., Kotzsh, A., Nielsen, F. C., Wewer, U. M. & Frohlich, C., 15 Oct 2013, In: Journal of Cell Science. 126, 20, p. 4707-20 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  53 Citations (Scopus)

• Regulation of ROCK Activity in Cancer

  Morgan-Fisher, M., Wewer, U. M. & Yoneda, A., 29 Jan 2013, In: Journal of Histochemistry and Cytochemistry. 61, 3, p. 185-198

  Research output: Contribution to journal › Journal article › Research › peer-review
  100 Citations (Scopus)
• 2012

  A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II

  Yoneda, A., Morgan-Fisher, M., Wait, R., Couchman, J. R. & Wewer, U. M., 2012, In: Molecular and Cellular Biology. 32, 10, p. 1788-804 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism

  Hansen, D. S., Leyme, A., Grandal, M. V., Albrechtsen, R., van Deurs, B., Wewer, U. & Kveiborg, M., 2012, In: Traffic - International Journal of Intracellular Transport. 13, 11, p. 1532-46 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Functional Analysis of a Breast Cancer-Associated Mutation in the Intracellular Domain of the Metalloprotease ADAM12

  Stautz, D., Wewer, U. M. & Kveiborg, M., 2012, In: P L o S One. 7, 5, p. e37628

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• The newcomer in the integrin family: Integrin α9 in biology and cancer.

  Høye, A. M., Couchman, J. R., Wewer, U. M., Yoneda, A. & Fukami, K., May 2012, In: Advances in Biological Regulation. 52, 2, p. 326-339

  Research output: Contribution to journal › Review › Research › peer-review
  51 Citations (Scopus)
• 2011

  ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression

  Frohlich, C., Nehammer, C., Albrechtsen, R., Kronqvist, P., Kveiborg, M., Sehara-Fujisawa, A., Mercurio, A. M. & Wewer, U. M., 29 Aug 2011, In: Molecular Cancer Research.

  Research output: Contribution to journal › Journal article › Research › peer-review
  46 Citations (Scopus)

• Aging, longevity and health

  Rasmussen, L. J., Sander, M., Wewer, U. M. & Bohr, V. A., 23 Jul 2011, In: Mechanisms of Ageing and Development. p. 522-32 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity

  Albrechtsen, R., Hansen, D. S., Sanjay, A., Kveiborg, M. & Wewer, U. M., 15 Jan 2011, In: Experimental Cell Research. 317, 2, p. 195-209 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• KU bestemmer selv over sin forskning

  Wewer, U. M., Holst, J. J., Schwartz, T. W. & Quistorff, B., 2 Jun 2011, In: Universitetsavisen.

  Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication
• 2010

  ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity

  Stautz, D., Sanjay, A., Hansen, M. T., Albrechtsen, R., Wewer, U. M. & Kveiborg, M., 2010, In: Experimental Cell Research. 316, 1, p. 55-67

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)

• Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

  Kveiborg, M., Jacobsen, J., Lee, M-H., Nagase, H., Wewer, U. M. & Murphy, G., 2010, In: Biochemical Journal. 430, 1, p. 79-86 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)
• 2009

  Alpha9beta1 integrin in melanoma cells can signal different adhesion states for migration and anchorage

  Lydolph, M. C., Morgan-Fisher, M., Høye, A. M., Couchman, J. R., Wewer, U. M. & Yoneda, A., 2009, In: Experimental Cell Research. 315, 19, p. 3312-24 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  41 Citations (Scopus)

• Impaired cutaneous wound healing in mice lacking tetranectin

  Iba, K., Hatakeyama, N., Kojima, T., Murata, M., Matsumura, T., Wewer, U. M., Wada, T., Sawada, N. & Yamashita, T., 2009, In: Wound Repair and Regeneration. 17, 1, p. 108-12 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Targeting ADAM12 in human disease: head, body or tail?

  Jacobsen, J. & Wewer, U. M., 2009, In: Current Pharmaceutical Design. 15, 20, p. 2300-10 10 p.

  Research output: Contribution to journal › Review › Research

  37 Citations (Scopus)
• 2008

  ADAM12: a potential target for the treatment of chronic wounds

  Harsha, A., Stojadinovic, O., Brem, H., Sehara-Fujisawa, A., Wewer, U. M., Loomis, C. A., Blobel, C. P. & Tomic-Canic, M., 1 Aug 2008, In: Journal of Molecular Medicine. 86, 8, p. 961-9 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  48 Citations (Scopus)

• Aging-From molecules to populations.

  Sander, M., Avlund, K., Lauritzen, M., Gottlieb, T., Stevnsner, T., Wewer, U. & Bohr, V. A., 2008, In: Mechanisms of Ageing and Development. 129, p. 614-623

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Catalytic properties of ADAM12 and its domain deletion mutants.

  Jacobsen, J., Visse, R., Sørensen, H. P., Enghild, J. J., Brew, K., Wewer, U. M. & Nagase, H., 2008, In: Biochemistry. 47, 2, p. 537-547 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  54 Citations (Scopus)

• Cellular roles of ADAM12 in health and disease.

  Kveiborg, M., Albrechtsen, R., Couchman, J. R. & Wewer, U. M., 2008, In: International Journal of Biochemistry & Cell Biology. 40, 9, p. 1685-702 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  159 Citations (Scopus)

• Expression, purification and insights into structure and folding of the ADAM22 pro domain.

  Sørensen, H. P., Jacobsen, J., Nielbo, S., Poulsen, F. M. & Wewer, U. M., 2008, In: Protein Expression and Purification. 61, 2, p. 175-83 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Heparan sulfate regulates ADAM12 through a molecular switch mechanism.

  Sørensen, H. P., Vives, R. R., Manetopoulos, C., Albrechtsen, R., Lydolph, M. C., Jacobsen, J., Couchman, J. R. & Wewer, U. M., 2008, In: Journal of Biological Chemistry.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• Urinary metalloproteinases: noninvasive biomarkers for breast cancer risk assessment

  Pories, S. E., Zurakowski, D., Roy, R., Lamb, C. C., Raza, S., Exarhopoulos, A., Scheib, R. G., Schumer, S., Lenahan, C., Borges, V., Louis, G. W., Anand, A., Isakovich, N., Hirshfield-Bartek, J., Wewer, U., Lotz, M. M. & Moses, M. A., 1 May 2008, In: Cancer Epidemiology, Biomarkers & Prevention. 17, 5, p. 1034-42 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  85 Citations (Scopus)
• 2007

  ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome

  Christiansen, M., Spencer, K., Laigaard, J., Cowans, N. J., Larsen, S. O. & Wewer, U. M., 2007, In: Prenatal Diagnosis. 27, 7, p. 611-615 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• Forsknings- og ytringsfriheden på universiteterne: forskningspolitisk årsmøde 2007

  Kærgård, N., Bache, C., Flensted-Jensen, M., Harder, P., Olesen, S-P. & Wewer, U. M., 2007, København: Det Kongelige Danske Videnskabernes Selskab.

  Research output: Book/Report › Book › Communication

  Open Access

  File
  1529 Downloads (Pure)

• The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor

  Atfi, A., Dumont, E., Colland, F., Bonnier, D., L'helgoualc'h, A., Prunier, C., Ferrand, N., Clément, B., Wewer, U. M. & Théret, N., 2007, In: Journal of Cell Biology. 178, 2, p. 201-208 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  103 Citations (Scopus)

• Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice

  Jørgensen, L. H., Jensen, C. H., Wewer, U. M. & Schrøder, H. D., 1 Nov 2007, In: American Journal of Pathology. 171, 5, p. 1599-607 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)
• 2006

  ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome

  Laigaard, J., Spencer, K., Christiansen, M., Cowans, N. J., Larsen, S. O., Pedersen, B. N. & Wewer, U. M., 2006, In: Prenatal Diagnosis. 26, 10, p. 973-979 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  61 Citations (Scopus)

• ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.

  Wewer, U. M., Mörgelin, M., Holck, P., Jacobsen, J., Lydolph, M. C., Johnsen, A. H., Kveiborg, M. & Albrechtsen, R., 2006, In: Journal of Biological Chemistry. 281, 14, p. 9418-22 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  58 Citations (Scopus)

• ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation.

  Kveiborg, M., Albrechtsen, R., Rudkjaer, L., Wen, G., Damgaard-Pedersen, K. & Wewer, U. M., 2006, In: Journal of Bone and Mineral Research. 21, 8, p. 1288-96 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  39 Citations (Scopus)

• Maternal serum ADAM12 levels in Down and Edwards' syndrome pregnancies at 9-12 weeks' gestation

  Laigaard, J., Cuckle, H., Wewer, U. M. & Christiansen, M., 2006, In: Prenatal Diagnosis. 26, 8, p. 689-691 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  46 Citations (Scopus)

• Molecular profiling of ADAM12 in human bladder cancer.

  Albrechtsen, R., Dyrskjøt, L., Rudkjaer, L., Ørntoft, T. F., Frohlich, C. & Wewer, U. M., 2006, In: Clinical Cancer Research. 12, 24, p. 7359-68 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  110 Citations (Scopus)

• RNA-binding IMPs promote cell adhesion and invadopodia formation.

  Vikesaa, J., Hansen, T. V. O., Jønson, L., Borup, R., Wewer, U. M., Christiansen, J. & Nielsen, F. C., 2006, In: EMBO Journal. 25, 7, p. 1456-68 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  283 Citations (Scopus)
• 2005

  ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation

  Lafuste, P., Sonnet, C., Chazaud, B., Dreyfus, P. A., Gherardi, R. K., Wewer, U. M. & Authier, F-J., 1 Feb 2005, In: Molecular Biology of the Cell. 16, 2, p. 861-70 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  83 Citations (Scopus)

• ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.

  Thodeti, C. K., Frohlich, C., Nielsen, C. K., Takada, Y., Fässler, R., Albrechtsen, R. & Wewer, U. M., 2005, In: FEBS Letters. 579, 25, p. 5589-95 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy

  Guo, L. T., Shelton, G. D., Wewer, U. M. & Engvall, E., 1 Nov 2005, In: Neuromuscular Disorders. 15, 11, p. 786-9 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• A role for ADAM12 in breast tumor progression and stromal cell apoptosis.

  Kveiborg, M., Frohlich, C., Albrechtsen, R., Tischler, V., Dietrich, N., Holck, P., Kronqvist, P., Rank, F., Mercurio, A. M. & Wewer, U. M., 2005, In: Cancer Research. 65, 11, p. 4754-61 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  126 Citations (Scopus)

• Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer

  Hammer, N. A., Hansen, T. V. O., Byskov, A. G., Rajpert-De Meyts, E., Grøndahl, M. L., Bredkjaer, H. E., Wewer, U. M., Christiansen, J. & Nielsen, F. C., 2005, In: Reproduction. 130, 2, p. 203-12 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  125 Citations (Scopus)

• Hierarchy of ADAM12 binding to integrins in tumor cells.

  Thodeti, C. K., Fröhlich, C., Nielsen, C. K., Holck, P., Sundberg, C., Kveiborg, M., Mahalingam, Y., Albrechtsen, R., Couchman, J. R. & Wewer, U. M., 2005, In: Experimental Cell Research. 309, 2, p. 438-50 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells

  Le Pabic, H., L'Helgoualc'h, A., Coutant, A., Wewer, U. M., Baffet, G., Clément, B. & Théret, N., 1 Dec 2005, In: Journal of Hepatology. 43, 6, p. 1038-44 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  55 Citations (Scopus)

• PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

  Li, S., Bordoy, R., Stanchi, F., Moser, M., Braun, A., Kudlacek, O., Wewer, U. M., Yurchenco, P. D. & Fässler, R., 1 Jul 2005, In: Journal of Cell Science. 118, Pt 13, p. 2913-21 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  86 Citations (Scopus)

• Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia.

  Laigaard, J., Sørensen, T., Placing, S., Holck, P., Frohlich, C., Wøjdemann, K. R., Sundberg, K., Shalmi, A-C., Tabor, A., Nørgaard-Pedersen, B., Ottesen, B., Christiansen, M. & Wewer, U. M., 2005, In: Obstetrics and Gynecology. 106, 1, p. 144-9 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  108 Citations (Scopus)

• Sub-cellular localisation of fukutin related protein in different cell lines and in the muscle of patients with MDC1C and LGMD2I

  Torelli, S., Brown, S. C., Brockington, M., Dolatshad, N. F., Jimenez, C., Skordis, L., Feng, L. H., Merlini, L., Jones, D. H., Romero, N., Wewer, U., Voit, T., Sewry, C. A., Noguchi, S., Nishino, I. & Muntoni, F., 1 Dec 2005, In: Neuromuscular Disorders. 15, 12, p. 836-43 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18.

  Laigaard, J., Christiansen, M., Frohlich, C., Pedersen, B. N., Ottesen, B. & Wewer, U. M., 2005, In: Prenatal Diagnosis. 25, 1, p. 45-6 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)
• 2004

  ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage

  Roy, R., Wewer, U. M., Zurakowski, D., Pories, S. E. & Moses, M. A., 3 Dec 2004, In: Journal of Biological Chemistry. 279, 49, p. 51323-30 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  215 Citations (Scopus)

• Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice

  Hansen, T. V. O., Hammer, N. A., Nielsen, J., Madsen, M., Dalbaeck, C., Wewer, U. M., Christiansen, J. & Nielsen, F. C., 2004, In: Molecular and Cellular Biology. 24, 10, p. 4448-64 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  196 Citations (Scopus)