Research output per year
Research output per year
Personal profile
Short presentation
My research is focused on diagnostic/therapeutic applications of monoclonal antibodies (mAbs). We develop mAbs (https://glycomics.ku.dk/research--resources/) to probe biosynthesis of mucin-type O-glycosylation and truncated cancer O-glycans. Our mAbs directed to mucins with truncated O-glycans have cancer-specific reactivity. One mAb designated 5E5 is directed to a cancer-specific epitope on mucin-1, and this is now in a phase 1 clinical trial (CAR-T) at UPENN/Tmunity with collaborators. A novel cell-based mucin display platform is used to explore immunogenicity of human cancer mucins for vaccine developments and to generate novel cancer-specific mAbs. One of these novel mAbs is currently under preclinical evaluation by a company.
Keywords
- Faculty of Health and Medical Sciences
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution
Chen, Y. H., Tian, W., Yasuda, M., Ye, Z., Song, M., Mandel, U., Kristensen, C., Povolo, L., Marques, A. R. A., Čaval, T., Heck, A. J. R., Sampaio, J. L., Johannes, L., Tsukimura, T., Desnick, R., Vakhrushev, S. Y., Yang, Z. & Clausen, H., 2023, In: Frontiers in Bioengineering and Biotechnology. 11, 1128371.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)38 Downloads (Pure) -
Display of the human mucinome with defined O-glycans by gene engineered cells
Nason, R., Büll, C., Konstantinidi, A., Sun, L., Ye, Z., Halim, A., Du, W., Sørensen, D. M., Durbesson, F., Furukawa, S., Mandel, U., Joshi, H. J., Dworkin, L. A., Hansen, L., David, L., Iverson, T. M., Bensing, B. A., Sullam, P. M., Varki, A. & Vries, E. D. & 6 others, , 2021, In: Nature Communications. 12, 1, 16 p., 4070.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile78 Citations (Scopus)101 Downloads (Pure) -
Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3
Rizzo, R., Russo, D., Kurokawa, K., Sahu, P., Lombardi, B., Supino, D., Zhukovsky, M. A., Vocat, A., Pothukuchi, P., Kunnathully, V., Capolupo, L., Boncompain, G., Vitagliano, C., Zito Marino, F., Aquino, G., Montariello, D., Henklein, P., Mandrich, L., Botti, G. & Clausen, H. & 11 others, , 2021, In: EMBO Journal. 40, e107238.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access65 Citations (Scopus) -
Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer
Thomas, D., Sagar, S., Liu, X., Lee, H. R., Grunkemeyer, J. A., Grandgenett, P. M., Caffrey, T., O'Connell, K. A., Swanson, B., Marcos-Silva, L., Steentoft, C., Wandall, H. H., Maurer, H. C., Peng, X. L., Yeh, J. J., Qiu, F., Yu, F., Madiyalakan, R., Olive, K. P. & Mandel, U. & 3 others, , 2021, In: Molecular Therapy. 29, 4, p. 1557-1571Research output: Contribution to journal › Journal article › Research › peer-review
Open Access42 Citations (Scopus) -
A Genetic Approach to Display and Dissect the Cancer-Associated O-Glycoepitome
Clausen, H., Nason, R., Mandel, U. & Narimatsu, Y., 2020, In: FASEB Journal. 34, S1, 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype
Beatson, R., Graham, R., Grundland Freile, F., Cozzetto, D., Kannambath, S., Pfeifer, E., Woodman, N., Owen, J., Nuamah, R., Mandel, U., Pinder, S., Gillett, C., Noll, T., Bouybayoune, I., Taylor-Papadimitriou, J. & Burchell, J. M., 2020, In: Communications Biology . 3, 15 p., 644.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile43 Citations (Scopus)78 Downloads (Pure) -
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells
Narimatsu, Y., Joshi, H. J., Nason, R., Van Coillie, J., Karlsson, R., Sun, L., Ye, Z., Chen, Y.-H., Schjoldager, K. T., Steentoft, C., Furukawa, S., Bensing, B. A., Sullam, P. M., Thompson, A. J., Paulson, J. C., Büll, C., Adema, G. J., Mandel, U., Hansen, L. & Bennett, E. P. & 4 others, , 2019, In: Molecular Cell. 75, 2, p. 394-407, e1-e5Research output: Contribution to journal › Journal article › Research › peer-review
Open Access174 Citations (Scopus) -
A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody
Steentoft, C., Fuhrmann, M., Battisti, F., Van Coillie, J., Madsen, T. D., Campos, D., Halim, A., Vakhrushev, S. Y., Joshi, H., Schreiber, H., Mandel, U. & Narimatsu, Y., 2019, In: Glycobiology. 29, 4, p. 307-319 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access19 Citations (Scopus)