Van Long Pham

Research output

Research output per year 2012 2021 2022 2023 2023

• 599 Citations
• 20 Journal article
• 1 Conference abstract for conference
• 1 Poster
• 1 Preprint

Research output per year

Research output per year

Search results

• 2023

  An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals

  Offersgaard, A., Duarte Hernandez, C. R., Feng, S., Marichal-Gallardo, P., Holmbeck, K., Pihl, A. F., Fernandez-Antunez, C., Alzua, G. P., Hartmann, K. T., Pham, L. V., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Schneider, U. V., Pedersen, G. K., Jensen, H. E., Christensen, J. P., Ramirez, S., Bukh, J. & Gottwein, J. M., 2023, In: iScience. 26, 2, 105949.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  60 Downloads (Pure)

• Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide

  Sherwood, A. V., Rivera-Rangel, L. R., Ryberg, L. A., Larsen, H. S., Anker, K. M., Costa, R., Vågbø, C. B., Jakljevič, E., Pham, L. V., Fernandez-Antunez, C., Indrisiunaite, G., Podolska-Charlery, A., Grothen, J. E. R., Langvad, N. W., Fossat, N., Offersgaard, A., Al-Chaer, A., Nielsen, L., Kuśnierczyk, A., Sølund, C. & 8 others, Weis, N., Gottwein, J. M., Holmbeck, K., Bottaro, S., Ramirez, S., Bukh, J., Scheel, T. K. H. & Vinther, J., 2023, In: Nature. 619, p. 811-818

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  12 Citations (Scopus)

• Substitutions in SARS-CoV-2 Mpro Selected by Protease Inhibitor Boceprevir Confer Resistance to Nirmatrelvir

  Gammeltoft, K. A., Zhou, Y., Ryberg, L. A., Pham, L. V., Binderup, A., Duarte Hernandez, C. R., Offersgaard, A., Fahnøe, U., Peters, G. H. J., Ramirez, S., Bukh, J. & Gottwein, J. M., 2023, In: Viruses. 15, 9, 17 p., 1970.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Citations (Scopus)

  12 Downloads (Pure)
• 2022

  Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals

  Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P., Ramirez Almeida, S. & 4 others, Reichl, U., Genzel, Y., Bukh, J. & Gottwein, J. M., 6 Jul 2022.

  Research output: Contribution to conference › Poster › Communication

• Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals

  Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Holmbeck, K., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P. & 5 others, Ramirez Almeida, S., Reichl, U., Genzel, Y., Bukh, J. & Gottwein, J. M., 6 Jul 2022.

  Research output: Contribution to conference › Conference abstract for conference › Communication

• HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4

  Pham, L. V., Pedersen, M. S., Fahnøe, U., Fernandez-Antunez, C., Humes, D., Schønning, K., Ramirez, S. & Bukh, J., 2022, In: Gut. 71, p. 627-642 20323585.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  36 Downloads (Pure)

• Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system

  Zhou, Y., Gammeltoft, K. A., Ryberg, L. A., Pham, L. V., Tjørnelund, H. D., Binderup, A., Hernandez, C. R. D., Fernandez-Antunez, C., Offersgaard, A., Fahnøe, U., Peters, G. H. J., Ramirez, S., Bukh, J. & Gottwein, J. M., 2022, In: Science Advances. 8, 51, eadd7197.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  81 Citations (Scopus)

  10 Downloads (Pure)

• Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization

  Pham, L. V., Velázquez-Moctezuma, R., Fahnøe, U., Collignon, L., Bajpai, P., Sølund, C., Weis, N., Holmbeck, K., Prentoe, J. & Bukh, J., 2022, In: Viruses. 14, 11, 2527.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  16 Downloads (Pure)

• Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication

  Fahnøe, U., Pham, L. V., Fernandez-Antunez, C., Costa, R., Rivera-Rangel, L. R., Galli, A., Feng, S., Mikkelsen, L. S., Gottwein, J. M., Scheel, T. K. H., Ramirez, S. & Bukh, J., 2022, In: Viruses. 14, 2, 172.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

  55 Downloads (Pure)
• 2021

  Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro

  Gammeltoft, K. A., Zhou, Y., Duarte Hernandez, C. R., Galli, A., Offersgaard, A., Costa, R., Pham, L. V., Fahnøe, U., Feng, S., Scheel, T. K. H., Ramirez, S., Bukh, J. & Gottwein, J. M., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, e02680-20.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  27 Citations (Scopus)

  32 Downloads (Pure)

• In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

  Zhou, Y., Gilmore, K., Ramirez, S., Settels, E., Gammeltoft, K. A., Pham, L. V., Fahnøe, U., Feng, S., Offersgaard, A., Trimpert, J., Bukh, J., Osterrieder, K., Gottwein, J. M. & Seeberger, P. H., 2021, In: Scientific Reports. 11, 14571.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  64 Citations (Scopus)

  61 Downloads (Pure)

• Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication

  Ramirez, S., Fernandez-Antunez, C., Galli, A., Underwood, A., Pham, L. V., Ryberg, L. A., Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Sølund, C., Weis, N., Gottwein, J. M., Fahnøe, U. & Bukh, J., 2021, In: Antimicrobial Agents and Chemotherapy. 65, 7, 20 p., e00097-21.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  55 Citations (Scopus)

• Sars-cov-2 production in a scalable high cell density bioreactor

  Offersgaard, A., Hernandez, C. R. D., Pihl, A. F., Costa, R., Venkatesan, N. P., Lin, X., Van Pham, L., Feng, S., Fahnøe, U., Scheel, T. K. H., Ramirez, S., Reichl, U., Bukh, J., Genzel, Y. & Gottwein, J. M., 2021, In: Vaccines. 9, 7, 706.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  19 Citations (Scopus)

  65 Downloads (Pure)
• 2020

  Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compounds

  Ramirez, S., Fernandez-Antunez, C., Pham, L. V., Ryberg, L. A., Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Gottwein, J. M., Fahnøe, U. & Bukh, J., 2020, bioRxiv.

  Research output: Working paper › Preprint

  Open Access
• 2019

  Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

  Jensen, S. B., Fahnøe, U., Pham, L. V., Serre, S. B. N., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez, S., Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J. M., Sarrazin, C., Weis, N., Schønning, K., Krarup, H., Bukh, J. & 1 others, Gottwein, J. M., 2019, In: Hepatology. 70, 3, p. 771-787 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  43 Citations (Scopus)

  200 Downloads (Pure)

• HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

  Pham, L. V., Jensen, S. B., Fahnøe, U., Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez, S., Humes, D., Serre, S. B. N., Schønning, K., Bukh, J. & Gottwein, J. M., 2019, In: Journal of Hepatology. 70, 3, p. 388-397

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)
• 2018

  Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants

  Gottwein, J. M., Pham, L. V., Mikkelsen, L. S., Ghanem, L., Ramirez, S., Scheel, T. K. H., Carlsen, T. H. R. & Bukh, J., Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  85 Citations (Scopus)

• HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

  Pham, L., Ramirez Almeida, S., Gottwein, J. M., Fahnøe, U., Li, Y., Pedersen, J. & Bukh, J., 2018, In: Gastroenterology. 154, 8, p. 2194-2208.e12

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)
• 2017

  Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors

  Pham, L. V., Ramirez Almeida, S., Carlsen, T. H. R., Li, Y-P., Gottwein, J. M. & Bukh, J., 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  10 Citations (Scopus)
• 2016

  Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir

  Li, Y., Pham, L., Uzcategui, N. & Bukh, J., Jun 2016, In: Journal of General Virology. 97, p. 1381-1394

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)
• 2014

  Stearoyl coenzyme A desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replication.

  Nguyen, LN., Lim, YS., Pham, L., Shin, HY., Kim, YS. & Hwang, SB., Nov 2014, In: Journal of Virology. 88, 21, p. 12311-12325

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)
• 2013

  Modulation of mitogen-activated protein kinase-activated protein kinase 3 by hepatitis C virus core protein.

  Ngo, HT., Pham, L., Kim, JW., Lim, YS. & Hwang, SB., May 2013, In: Journal of Virology. 87, 10, p. 5718-5731

  Research output: Contribution to journal › Journal article › Research › peer-review

  21 Citations (Scopus)
• 2012

  Hepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation

  Pham, L., Ngo, HT., Lim, YS. & Hwang, SB., Nov 2012, In: Journal of Hepatology. 57, 5, p. 960-966 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  19 Citations (Scopus)