Research output per year
Research output per year
Personal profile
Fields of interest
- DNA Damage Repair
- Eukaryotic DNA Replication
- Xenopus cell-free extract system
- Cell Biology
- Molecular Biology
- Eukaryotic Transcription
- Cancer Biology
Current research
DNA Damage Response and Eukaryotic DNA Replication
- DNA-protein crosslink (DPC) repair
- Topoisomerase induced DNA damage repair
- DNA damage response pathway
- Eukaryotic replicaiton
Eukaryotic Transcription Kinetics
Functional gene expression is crucial for proper cellular functions and reproduction. RNA polymerase II (Pol II) plays an irreplaceable role in ensuring function gene expression by conducting the transcription of all genes and coordinating their co-transcriptional mRNA processing events (i.e. splicing). Recently, A kinetic model of transcription offers a better way to understand the connection between transcription and co-transcriptional events. However, obtaining direct support for the biological significance of the kinetic model is often challenging due to pleiotropic effects of perturbing transcription. The transcription elongation speed is a core parameter in the kinetic model of transcription, which is tightly linked to co-transcriptional events. To address the biological significance of transcription speed in plant development we are focusing on the transcription kinetics of Pol II in model plant Arabidopsis.
Education/Academic qualification
Molecular Biology, PhD, University of Copenhagen
1 Feb 2016 → 30 Nov 2019
Award Date: 6 Dec 2019
Plant Biotechnology, MSc, Wageningen University & Research
25 Aug 2013 → 25 Sep 2015
Award Date: 25 Sep 2015
Biology, BSc, Huazhong Agricultural University
1 Sep 2009 → 1 Jul 2013
Award Date: 20 Jun 2013
Keywords
- Faculty of Science
- Geneticallt modified animals, plants and organisms (GMO)
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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PARP1-dependent DNA-protein crosslink repair
Fábián, Z., Kakulidis, E. S., Hendriks, I. A., Kühbacher, U., Larsen, N. B., Oliva-Santiago, M., Wang, J., Leng, X., Dirac-Svejstrup, A. B., Svejstrup, J. Q., Nielsen, M. L., Caldecott, K. & Duxin, J. P., 2024, In: Nature Communications. 15, 18 p., 6641.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)4 Downloads (Pure) -
Targeting DNA-Protein Crosslinks via Post-Translational Modifications
Leng, X. & Duxin, J. P., 2022, In: Frontiers in Molecular Biosciences. 9, 14 p., 944775.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile10 Citations (Scopus)14 Downloads (Pure) -
A G(enomic)P(ositioning)S(ystem) for Plant RNAPII Transcription
Leng, X., Thomas, Q., Rasmussen, S. H. & Marquardt, S., 2020, In: Trends in Plant Science. 25, 8, p. 744-764Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile23 Citations (Scopus)43 Downloads (Pure) -
Organismal benefits of transcription speed control at gene boundaries
Leng, X., Ivanov, M., Kindgren, P., Malik, I., Thieffry, A., Brodersen, P., Sandelin, A., Kaplan, C. D. & Marquardt, S., 2020, In: EMBO Reports. 21, 4, 16 p., e49315.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile25 Citations (Scopus)172 Downloads (Pure) -
The Roles of Transcription Speed and Transcriptional Interference in Plant Gene Expression
Leng, X., 2019, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
File -
Transcription-driven chromatin repression of Intragenic transcription start sites
Nielsen, M., Ard, R., Leng, X., Ivanov, M., Kindgren, P. R., Pelechano, V. & Marquardt, S., 1 Feb 2019, In: PLOS Genetics. 15, 2, p. 1-33 e1007969.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile58 Citations (Scopus)367 Downloads (Pure)
Activities
- 1 Membership in committee, council, board
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Danish RNA society (External organisation)
Xueyuan Leng (Member)
2016 → 2019Activity: Membership types › Membership in committee, council, board