Yen-Hsi Chen

Research output

Research output per year 2015 2018 2021 2024

• 721 Citations
• 15 Journal article
• 1 Ph.D. thesis
• 1 Comment/debate
• 1 Review

Research output per year

Research output per year

Search results

• 2024

  Mammalian cell-based production of glycans, glycopeptides and glycomodules

  Jaroentomeechai, T., Karlsson, R., Goerdeler, F., Teoh, F. K. Y., Grønset, M. N., de Wit, D., Chen, Y-H., Furukawa, S., Psomiadou, V., Hurtado-Guerrero, R., Vidal-Calvo, E. E., Salanti, A., Boltje, T. J., van den Bos, L. J., Wunder, C., Johannes, L., Schjoldager, K. T., Joshi, H. J., Miller, R. L., Clausen, H. & 2 others, Vakhrushev, S. Y. & Narimatsu, Y., 8 Nov 2024, In: Nature Communications. 15, 1, p. 9668

  Research output: Contribution to journal › Journal article › Research › peer-review

• Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate

  Vidal-Calvo, E. E., Martin-Salazar, A., Choudhary, S., Dagil, R., Raghavan, S. S. R., Duvnjak, L., Nordmaj, M. A., Clausen, T. M., Skafte, A., Oberkofler, J., Wang, K., Agerbæk, M. Ø., Løppke, C., Jørgensen, A. M., Ropac, D., Mujollari, J., Willis, S., Garcias López, A., Miller, R. L., Karlsson, R. T. G. & 21 others, Goerdeler, F., Chen, Y-H., Colaço, A. R., Wang, Y., Lavstsen, T., Martowicz, A., Nelepcu, I., Marzban, M., Oo, H. Z., Ørum-Madsen, M. S., Wang, Y., Nielsen, M. A., Clausen, H., Wierer, M., Wolf, D., Gögenur, I., Theander, T. G., Al-Nakouzi, N., Gustavsson, T., Daugaard, M. & Salanti, A., 2024, In: Nature Communications. 15, 1, 20 p., 7553.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  13 Downloads (Pure)
• 2023

  A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution

  Chen, Y. H., Tian, W., Yasuda, M., Ye, Z., Song, M., Mandel, U., Kristensen, C., Povolo, L., Marques, A. R. A., Čaval, T., Heck, A. J. R., Sampaio, J. L., Johannes, L., Tsukimura, T., Desnick, R., Vakhrushev, S. Y., Yang, Z. & Clausen, H., 2023, In: Frontiers in Bioengineering and Biotechnology. 11, 1128371.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Citations (Scopus)

  33 Downloads (Pure)

• Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection

  Bagdonaite, I., Marinova, I. N., Rudjord-Levann, A. M., Pallesen, E. M. H., King-Smith, S. L., Karlsson, R., Rømer, T. B., Chen, Y-H., Miller, R. L., Olofsson, S., Nordén, R., Bergström, T., Dabelsteen, S. & Wandall, H. H., 2023, In: Nature Communications. 14, 19 p., 7000.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  3 Citations (Scopus)

  18 Downloads (Pure)
• 2022

  Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction

  Guimond, S. E., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., Le, T. T., Spalluto, C. M., Humbert, M. V., Buttigieg, K. R., Coombes, N., Elmore, M. J., Wand, M., Nyström, K., Said, J., Setoh, Y. X., Amarilla, A. A., Modhiran, N., Sng, J. D. J., Chhabra, M., Young, P. R., Rawle, D. J. & 22 others, Lima, M. A., Yates, E. A., Karlsson, R., Miller, R. L., Chen, Y. H., Bagdonaite, I., Yang, Z., Stewart, J., Nguyen, D., Laidlaw, S., Hammond, E., Dredge, K., Wilkinson, T. M. A., Watterson, D., Khromykh, A. A., Suhrbier, A., Carroll, M. W., Trybala, E., Bergström, T., Ferro, V., Skidmore, M. A. & Turnbull, J. E., 2022, In: ACS Central Science. 8, 5, p. 527-545 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  59 Citations (Scopus)

  17 Downloads (Pure)
• 2021

  Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

  Karlsson, R., Chopra, P., Joshi, A., Yang, Z., Vakhrushev, S. Y., Clausen, T. M., Painter, C. D., Szekeres, G. P., Chen, Y. H., Sandoval, D. R., Hansen, L., Esko, J. D., Pagel, K., Dyer, D. P., Turnbull, J. E., Clausen, H., Boons, G. J. & Miller, R. L., 2021, In: Science Advances. 7, 52, eabl6026.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  29 Citations (Scopus)

  36 Downloads (Pure)

• Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

  Schuurs, Z. P., Hammond, E., Elli, S., Rudd, T. R., Mycroft-West, C. J., Lima, M. A., Skidmore, M. A., Karlsson, R., Chen, Y-H., Bagdonaite, I., Yang, Z., Ahmed, Y. A., Richard, D. J., Turnbull, J., Ferro, V., Coombe, D. R. & Gandhi, N. S., 2021, In: Computational and Structural Biotechnology Journal. 19, p. 2806-2818 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  32 Citations (Scopus)

  22 Downloads (Pure)

• Genetic glycoengineering in mammalian cells

  Narimatsu, Y., Büll, C., Chen, Y. H., Wandall, H. H., Yang, Z. & Clausen, H., 2021, In: Journal of Biological Chemistry. 296, 25 p., 100448.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  64 Citations (Scopus)

  63 Downloads (Pure)

• The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

  Jorgensen, A. S., Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, K. L., Moussouras, N. A., Vilhardt, F., Kalinski, P., Basse, P., Chen, Y-H., Yang, Z., Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, P. J., Lahl, K., Goth, C. K., Rosenkilde, M. M. & Hjorto, G. M., 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

  22 Downloads (Pure)

• The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models

  Davies, S. P., Mycroft-West, C. J., Pagani, I., Hill, H. J., Chen, Y. H., Karlsson, R., Bagdonaite, I., Guimond, S. E., Stamataki, Z., De Lima, M. A., Turnbull, J. E., Yang, Z., Vicenzi, E., Skidmore, M. A., Khanim, F. L. & Richardson, A., 2021, In: Frontiers in Pharmacology. 12, 660490.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  26 Citations (Scopus)

  18 Downloads (Pure)

• Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations

  Tree, J. A., Turnbull, J. E., Buttigieg, K. R., Elmore, M. J., Coombes, N., Hogwood, J., Mycroft-West, C. J., Lima, M. A., Skidmore, M. A., Karlsson, R., Chen, Y. H., Yang, Z., Spalluto, C. M., Staples, K. J., Yates, E. A., Gray, E., Singh, D., Wilkinson, T., Page, C. P. & Carroll, M. W., 2021, In: British Journal of Pharmacology. 178, 3, p. 626-635 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  77 Citations (Scopus)

  50 Downloads (Pure)
• 2019

  An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

  Narimatsu, Y., Joshi, H. J., Nason, R., Van Coillie, J., Karlsson, R., Sun, L., Ye, Z., Chen, Y-H., Schjoldager, K. T., Steentoft, C., Furukawa, S., Bensing, B. A., Sullam, P. M., Thompson, A. J., Paulson, J. C., Büll, C., Adema, G. J., Mandel, U., Hansen, L., Bennett, E. P. & 4 others, Varki, A., Vakhrushev, S. Y., Yang, Z. & Clausen, H., 2019, In: Molecular Cell. 75, 2, p. 394-407, e1-e5

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  160 Citations (Scopus)

• The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

  Tian, W., Ye, Z., Wang, S., Schulz, M. A., Van Coillie, J., Sun, L., Chen, Y-H., Narimatsu, Y., Hansen, L., Kristensen, C., Mandel, U., Bennett, E. P., Jabbarzadeh-Tabrizi, S., Schiffmann, R., Shen, J-S., Vakhrushev, S. Y., Clausen, H. & Yang, Z., 2019, In: Nature Communications. 10, 13 p., 1785.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  53 Citations (Scopus)

  214 Downloads (Pure)
• 2018

  A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome

  Narimatsu, Y., Joshi, H. J., Zhang, Y., Gomes, C., Chen, Y-H., Lorenzetti, F., Furukawa, S., Schjoldager, K., Hansen, L., Clausen, H., Bennett, E. P. & Wandall, H. H., 2018, In: Glycobiology. 28, 5, p. 295–305

  Research output: Contribution to journal › Journal article › Research › peer-review
  66 Citations (Scopus)

• Glycoengineering design options for IgG1 in CHO cells using precise gene editing

  Schulz, M. A., Tian, W., Mao, Y., Van Coillie, J., Sun, L., Larsen, J. S., Chen, Y-H., Kristensen, C., Vakhrushev, S. Y., Clausen, H. & Yang, Z., 2018, In: Glycobiology. 28, 7, p. 542–549

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• The GAGOme: a cell-based library of displayed glycosaminoglycans

  Chen, Y-H., Narimatsu, Y., Clausen, T. M., Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, T., Salanti, A., Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, E. P., Mao, Y., Clausen, H. & Yang, Z., 2018, In: Nature Methods. 15, 11, p. 881-888

  Research output: Contribution to journal › Journal article › Research › peer-review
  107 Citations (Scopus)

• Turning Glycosaminoglycans into Lego-toying

  Chen, Y-H., 20 Apr 2018, Københavns Universitet.

  Research output: Book/Report › Ph.D. thesis › Research
• 2015

  A novel chemosensitivity profiling platform for small acute lymphoblastic leukemia cell populations

  Groth-Pedersen, L., Chen, Y-H., Faber, M., Valentin, R., Albertsen, B. K., Wehner, P. S., Rosthøj, S., Frandsen, T. L., Marquart, H. V. & Schmiegelow, K., 2015, In: Leukemia and Lymphoma. 56, 7, p. 2208-11 4 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review