1,2,3-triazolyl amino acids as AMPA receptor ligands

Nathan J. Stanley; Daniel Sejer Pedersen; Birgitte Nielsen; Trine Kvist; Jesper M Mathiesen; Hans Bräuner-Osborne; Dennis K Taylor; Andrew D Abell

doi:10.1016/j.bmcl.2010.09.139

1,2,3-triazolyl amino acids as AMPA receptor ligands

Nathan J. Stanley, Daniel Sejer Pedersen, Birgitte Nielsen, Trine Kvist, Jesper M Mathiesen, Hans Bräuner-Osborne, Dennis K Taylor, Andrew D Abell

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Abstract

The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	20
Issue number	24
Pages (from-to)	7512-7515
ISSN	0960-894X
DOIs	https://doi.org/10.1016/j.bmcl.2010.09.139
Publication status	Published - 15 Dec 2010

Bibliographical note

Keywords: synthesis; glutamate receptor; triazole

Keywords

Former Faculty of Pharmaceutical Sciences

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10.1016/j.bmcl.2010.09.139

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Cite this

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title = "1,2,3-triazolyl amino acids as AMPA receptor ligands",

abstract = "The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.",

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AU - Stanley, Nathan J.

AU - Pedersen, Daniel Sejer

AU - Nielsen, Birgitte

AU - Kvist, Trine

AU - Mathiesen, Jesper M

AU - Bräuner-Osborne, Hans

AU - Taylor, Dennis K

AU - Abell, Andrew D

N1 - Keywords: synthesis; glutamate receptor; triazole

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AB - The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

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U2 - 10.1016/j.bmcl.2010.09.139

DO - 10.1016/j.bmcl.2010.09.139

M3 - Journal article

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JO - Bioorganic & Medicinal Chemistry Letters

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