[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice

Mette Munk Jensen; Kamille Dumong Erichsen; Camilla Bardram Johnbeck; Fredrik Björkling; Jacob Madsen; Peter Buhl Jensen; Maxwell Sehested; Liselotte Højgaard; Andreas Kjær

doi:10.1186/1471-2407-13-168

[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice

Mette Munk Jensen, Kamille Dumong Erichsen, Camilla Bardram Johnbeck, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Maxwell Sehested, Liselotte Højgaard, Andreas Kjær

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Abstract

Belinostat is a histone deacetylase inhibitor with anti-tumor effect in several pre-clinical tumor models and clinical trials. The aim of the study was to evaluate changes in cell proliferation and glucose uptake by use of 3'-deoxy-3'-[(18)F]fluorothymidine ([18F]FLT) and 2-deoxy-2-[(18)F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) following treatment with belinostat in ovarian cancer in vivo models.

Original language	English
Article number	168
Journal	B M C Cancer
Volume	13
Pages (from-to)	1-9
Number of pages	10
ISSN	1471-2407
DOIs	https://doi.org/10.1186/1471-2407-13-168
Publication status	Published - 2013

Access to Document

10.1186/1471-2407-13-168

Cite this

[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice. / Jensen, Mette Munk; Erichsen, Kamille Dumong; Johnbeck, Camilla Bardram; Björkling, Fredrik; Madsen, Jacob; Jensen, Peter Buhl; Sehested, Maxwell; Højgaard, Liselotte ; Kjær, Andreas.

In: B M C Cancer, Vol. 13, 168, 2013, p. 1-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Jensen, Mette Munk ; Erichsen, Kamille Dumong ; Johnbeck, Camilla Bardram ; Björkling, Fredrik ; Madsen, Jacob ; Jensen, Peter Buhl ; Sehested, Maxwell ; Højgaard, Liselotte ; Kjær, Andreas. / [18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice. In: B M C Cancer. 2013 ; Vol. 13. pp. 1-9.

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abstract = "Belinostat is a histone deacetylase inhibitor with anti-tumor effect in several pre-clinical tumor models and clinical trials. The aim of the study was to evaluate changes in cell proliferation and glucose uptake by use of 3'-deoxy-3'-[(18)F]fluorothymidine ([18F]FLT) and 2-deoxy-2-[(18)F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) following treatment with belinostat in ovarian cancer in vivo models.",

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AU - Jensen, Mette Munk

AU - Erichsen, Kamille Dumong

AU - Johnbeck, Camilla Bardram

AU - Björkling, Fredrik

AU - Madsen, Jacob

AU - Jensen, Peter Buhl

AU - Sehested, Maxwell

AU - Højgaard, Liselotte

AU - Kjær, Andreas

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AB - Belinostat is a histone deacetylase inhibitor with anti-tumor effect in several pre-clinical tumor models and clinical trials. The aim of the study was to evaluate changes in cell proliferation and glucose uptake by use of 3'-deoxy-3'-[(18)F]fluorothymidine ([18F]FLT) and 2-deoxy-2-[(18)F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) following treatment with belinostat in ovarian cancer in vivo models.

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DO - 10.1186/1471-2407-13-168

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