[18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice

Mette Munk Jensen; Kamille Dumong Erichsen; Fredrik Björkling; J Madsen; Peter B Jensen; Maxwell Sehested; Liselotte Højgaard; Andreas Kjær

doi:10.1371/journal.pone.0050618

[18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice

Mette Munk Jensen, Kamille Dumong Erichsen, Fredrik Björkling, J Madsen, Peter B Jensen, Maxwell Sehested, Liselotte Højgaard, Andreas Kjær

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Abstract

3'-deoxy-3'-[¹⁸F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use [18F]FLT positron emission tomography (PET) to study non-invasively early anti-proliferative effects of the experimental chemotherapeutic agent TP202377 in both sensitive and resistant tumors.

Original language	English
Article number	e50618
Journal	P L o S One
Volume	7
Issue number	11
Pages (from-to)	e50618
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0050618
Publication status	Published - 2012

Keywords

Animals
Antineoplastic Agents
Biological Transport
Cell Line, Tumor
Cell Proliferation
Dideoxynucleosides
Female
Gene Expression Regulation, Neoplastic
Humans
Indoles
Ki-67 Antigen
Mice
Ovarian Neoplasms
Positron-Emission Tomography
Thymidine Kinase
Time Factors
Tomography, X-Ray Computed
Treatment Failure
Tumor Burden
Xenograft Model Antitumor Assays

Access to Document

10.1371/journal.pone.0050618

Cite this

Jensen, M. M., Erichsen, K. D., Björkling, F., Madsen, J., Jensen, P. B., Sehested, M., Højgaard, L., & Kjær, A. (2012). [18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice. P L o S One, 7(11), e50618. [e50618]. https://doi.org/10.1371/journal.pone.0050618

[18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice : studies with experimental chemotherapy TP202377 in human cancer xenografts in mice. / Jensen, Mette Munk; Erichsen, Kamille Dumong; Björkling, Fredrik; Madsen, J; Jensen, Peter B; Sehested, Maxwell; Højgaard, Liselotte ; Kjær, Andreas.

In: P L o S One, Vol. 7, No. 11, e50618, 2012, p. e50618.

Research output: Contribution to journal › Journal article › Research › peer-review

Jensen, MM, Erichsen, KD, Björkling, F, Madsen, J, Jensen, PB, Sehested, M, Højgaard, L & Kjær, A 2012, '[18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice', P L o S One, vol. 7, no. 11, e50618, pp. e50618. https://doi.org/10.1371/journal.pone.0050618

Jensen MM, Erichsen KD, Björkling F, Madsen J, Jensen PB, Sehested M et al. [18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice. P L o S One. 2012;7(11):e50618. e50618. https://doi.org/10.1371/journal.pone.0050618

Jensen, Mette Munk ; Erichsen, Kamille Dumong ; Björkling, Fredrik ; Madsen, J ; Jensen, Peter B ; Sehested, Maxwell ; Højgaard, Liselotte ; Kjær, Andreas. / [18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice : studies with experimental chemotherapy TP202377 in human cancer xenografts in mice. In: P L o S One. 2012 ; Vol. 7, No. 11. pp. e50618.

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abstract = "3'-deoxy-3'-[¹⁸F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use [18F]FLT positron emission tomography (PET) to study non-invasively early anti-proliferative effects of the experimental chemotherapeutic agent TP202377 in both sensitive and resistant tumors.",

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AU - Jensen, Mette Munk

AU - Erichsen, Kamille Dumong

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KW - Indoles

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KW - Xenograft Model Antitumor Assays

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