5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

Christian A. Olsen; Núria Parera; Fernando Albericio; Mercedes Álvarez

doi:10.1016/j.tetlet.2005.01.145

5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

Christian A. Olsen, Núria Parera, Fernando Albericio^*, Mercedes Álvarez

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

Abstract

Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1-b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.

Original language	English
Journal	Tetrahedron Letters
Volume	46
Issue number	12
Pages (from-to)	2041-2044
Number of pages	4
ISSN	0040-4039
DOIs	https://doi.org/10.1016/j.tetlet.2005.01.145
Publication status	Published - 21 Mar 2005

Keywords

Cross-coupling reactions
Heterocycles
Marine alkaloids
Palladium

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abstract = "Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1-b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.",

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AU - Parera, Núria

AU - Albericio, Fernando

AU - Álvarez, Mercedes

PY - 2005/3/21

Y1 - 2005/3/21

N2 - Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1-b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.

AB - Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1-b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.

KW - Cross-coupling reactions

KW - Heterocycles

KW - Marine alkaloids

KW - Palladium

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JF - Tetrahedron Letters

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ER -

5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

Abstract

Keywords

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