[99mTc]diphosphonate uptake and hemodynamics in experimental arthritis: effect of naproxen in the canine carrageenan injection model

E S Hansen, S Z He, K Søballe, D Kjølseth, T B Henriksen, V E Hjortdal, C Bünger

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3 Citations (Scopus)

Abstract

The impact of naproxen treatment on juxta-articular hemodynamics and bone metabolism in experimental juvenile arthritis was studied in the articular carrageenan injection model. Unilateral gonarthritis was induced for 12 weeks in eight dogs receiving naproxen (dosage, 2 mg/kg) and eight controls. Regional blood flow was assessed by the microsphere method, plasma volume by the distribution space of [125I]fibrinogen, and bone metabolism by the 2-h uptake of [99mTc]diphosphonate ([99mTc]DPD). Synovial effusion was less prominent with naproxen treatment as judged by joint fluid volume and pressure. Naproxen reduced the arthritic capsular hyperemia, almost normalized a severe blood flow increase in patella and both juxta-articular epiphyses, ameliorated an expansion of plasma volume in the patella and the distal femoral epiphysis, and normalized an increased [99mTc]DPD uptake in subchondral femoral bone and the tibial cortex. Significantly increased arteriovenous shunting in the arthritic extremity was unaffected by naproxen. The study suggests that long-term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta-articular bone secondary to synovial inflammation.

Original languageEnglish
JournalJournal of Orthopaedic Research
Volume10
Issue number5
Pages (from-to)647-56
Number of pages10
ISSN0736-0266
DOIs
Publication statusPublished - Sep 1992

Keywords

  • Animals
  • Arthritis/chemically induced
  • Bone and Bones/blood supply
  • Capillary Permeability/physiology
  • Carrageenan/administration & dosage
  • Diphosphonates/pharmacokinetics
  • Disease Models, Animal
  • Dogs
  • Growth Plate/blood supply
  • Hemodynamics/drug effects
  • Homeostasis
  • Injections
  • Microspheres
  • Naproxen/pharmacology
  • Regional Blood Flow
  • Technetium/pharmacokinetics
  • Technetium Compounds

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