A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications

Martina Aulitto; Laura Martinez-Alvarez; Gabriella Fiorentino; Danila Limauro; Xu Peng; Patrizia Contursi

doi:10.3390/ijms23063135

A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications

Martina Aulitto, Laura Martinez-Alvarez, Gabriella Fiorentino, Danila Limauro, Xu Peng, Patrizia Contursi^*

^*Corresponding author for this work

Functional Genomics

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

19 Downloads (Pure)

Abstract

The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain’s genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications.

Original language	English
Article number	3135
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	6
Number of pages	23
ISSN	1661-6596
DOIs	https://doi.org/10.3390/ijms23063135
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

B. coagulans
Bacteriocins
CAZymes
CRISPR-Cas systems

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FulltextFinal published version, 5.18 MBLicence: CC BY

Cite this

A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications. / Aulitto, Martina; Martinez-Alvarez, Laura; Fiorentino, Gabriella; Limauro, Danila; Peng, Xu; Contursi, Patrizia.

In: International Journal of Molecular Sciences , Vol. 23, No. 6, 3135, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain{\textquoteright}s genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications.",

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AU - Aulitto, Martina

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AU - Limauro, Danila

AU - Peng, Xu

AU - Contursi, Patrizia

PY - 2022

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AB - The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain’s genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications.

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