TY - JOUR
T1 - A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model
AU - Jie, Zhuye
AU - Zhu, Qian
AU - Zou, Yuanqiang
AU - Wu, Qili
AU - Qin, Min
AU - He, Dongdong
AU - Lin, Xiaoqian
AU - Tong, Xin
AU - Zhang, Jiahao
AU - Jie, Zhu
AU - Luo, Wenwei
AU - Xiao, Xiao
AU - Chen, Shiyu
AU - Wu, Yonglin
AU - Guo, Gongjie
AU - Zheng, Shufen
AU - Li, Yong
AU - Lai, Weihua
AU - Yang, Huanming
AU - Wang, Jian
AU - Xiao, Liang
AU - Chen, Jiyan
AU - Zhang, Tao
AU - Kristiansen, Karsten
AU - Jia, Huijue
AU - Zhong, Shilong
N1 - Publisher Copyright:
© 2023
PY - 2023
Y1 - 2023
N2 - By a survey of metagenome-wide association studies (MWAS), we found a robust depletion of Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection of bacteria isolated from healthy Chinese individuals, we selected B. cellulosilyticus, R. intestinalis, and Faecalibacterium longum, a bacterium related to F. prausnitzii, and tested the effects of these bacteria in an Apoe/− atherosclerosis mouse model. We show that administration of these three bacterial species to Apoe−/− mice robustly improves cardiac function, reduces plasma lipid levels, and attenuates the formation of atherosclerotic plaques. Comprehensive analysis of gut microbiota, plasma metabolome, and liver transcriptome revealed that the beneficial effects are associated with a modulation of the gut microbiota linked to a 7α-dehydroxylation–lithocholic acid (LCA)–farnesoid X receptor (FXR) pathway. Our study provides insights into transcriptional and metabolic impact whereby specific bacteria may hold promises for prevention/treatment of ACVD.
AB - By a survey of metagenome-wide association studies (MWAS), we found a robust depletion of Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection of bacteria isolated from healthy Chinese individuals, we selected B. cellulosilyticus, R. intestinalis, and Faecalibacterium longum, a bacterium related to F. prausnitzii, and tested the effects of these bacteria in an Apoe/− atherosclerosis mouse model. We show that administration of these three bacterial species to Apoe−/− mice robustly improves cardiac function, reduces plasma lipid levels, and attenuates the formation of atherosclerotic plaques. Comprehensive analysis of gut microbiota, plasma metabolome, and liver transcriptome revealed that the beneficial effects are associated with a modulation of the gut microbiota linked to a 7α-dehydroxylation–lithocholic acid (LCA)–farnesoid X receptor (FXR) pathway. Our study provides insights into transcriptional and metabolic impact whereby specific bacteria may hold promises for prevention/treatment of ACVD.
KW - Bacteriology
KW - Human metabolism
KW - Microbial metabolism
KW - Microbiology
U2 - 10.1016/j.isci.2023.106960
DO - 10.1016/j.isci.2023.106960
M3 - Journal article
C2 - 37378328
AN - SCOPUS:85161545611
VL - 26
JO - iScience
JF - iScience
SN - 2589-0042
IS - 6
M1 - 106960
ER -