A core outcome set for trials of infant-feeding interventions to prevent childhood obesity

Karen Matvienko-Sikar; Ciara Griffin; Colette Kelly; Caroline Heary; Majken Lillholm Pico Pedersen; Niamh McGrath; Elaine Toomey; Janas Harrington; Marita Hennessy; Michelle Queally; Catherine Hayes; Jenny McSharry; Declan Devane; Molly Byrne; Patricia M Kearney

doi:10.1038/s41366-020-0538-2

A core outcome set for trials of infant-feeding interventions to prevent childhood obesity

Karen Matvienko-Sikar^*, Ciara Griffin, Colette Kelly, Caroline Heary, Majken Lillholm Pico Pedersen, Niamh McGrath, Elaine Toomey, Janas Harrington, Marita Hennessy, Michelle Queally, Catherine Hayes, Jenny McSharry, Declan Devane, Molly Byrne, Patricia M Kearney

^*Corresponding author for this work

Obesity Research

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

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Abstract

Background: Standardisation of outcomes measured and reported in trials of infant-feeding interventions to prevent childhood obesity is essential to evaluate and synthesise intervention effects. The aim of this study is to develop an infant-feeding core outcome set for use in randomised trials of infant-feeding interventions, with children ≤1 year old, to prevent childhood obesity.

Methods: Core outcome set development followed four stages: (1) systematic review of outcomes reported in the extant literature; (2) meeting with national and international stakeholders to discuss and clarify identified outcomes; (3) e-Delphi study with national and international stakeholders to prioritise outcomes; (4) meeting with national and international stakeholders to reach consensus on outcomes. Stakeholders in stages 2–4 were paediatricians, general practitioners, nurses, midwives, non-clinician researchers, parents, dieticians, nutritionists, and childcare providers.

Results: Twenty-six outcomes were identified for inclusion in the core outcome set. These were grouped in nine outcome domains: ‘breastfeeding and formula feeding’, ‘introduction of solids’, ‘parent feeding practices and styles’, ‘parent knowledge and beliefs’, ‘practical feeding’, ‘food environment’, ‘dietary intake’, ‘perceptions of infant behaviour and preferences’, and ‘child weight’.

Conclusions: The core outcome set identified in this study is the minimum that should be measured and reported in trials of infant-feeding interventions to prevent childhood obesity. This standardisation of outcomes will enable more comprehensive examination and synthesis of the effects of infant-feeding interventions to prevent childhood obesity.

Original language	English
Journal	International Journal of Obesity
Volume	44
Issue number	10
Pages (from-to)	2035-2043
Number of pages	9
ISSN	0307-0565
DOIs	https://doi.org/10.1038/s41366-020-0538-2
Publication status	Published - 1 Oct 2020

Bibliographical note

Funding Information:
Funding This research was supported by a Health Research Board Interdisciplinary Capacity Enhancement Award (ICE-2015-1026) and an Irish Research Council New Foundations Award (2015). CG was in receipt of a Health Research Board-Trials Methodology Research Network (HRB-TMRN) summer studentship to support this research.

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.

Access to Document

10.1038/s41366-020-0538-2

Matvienko-Sikar COS_(accepted_verion)Accepted author manuscript, 980 KBLicence: CC BY-SA

Cite this

Matvienko-Sikar, K., Griffin, C., Kelly, C., Heary, C., Lillholm Pico Pedersen, M., McGrath, N., Toomey, E., Harrington, J., Hennessy, M., Queally, M., Hayes, C., McSharry, J., Devane, D., Byrne, M., & Kearney, P. M. (2020). A core outcome set for trials of infant-feeding interventions to prevent childhood obesity. International Journal of Obesity, 44(10), 2035-2043. https://doi.org/10.1038/s41366-020-0538-2

Matvienko-Sikar, K, Griffin, C, Kelly, C, Heary, C, Lillholm Pico Pedersen, M, McGrath, N, Toomey, E, Harrington, J, Hennessy, M, Queally, M, Hayes, C, McSharry, J, Devane, D, Byrne, M & Kearney, PM 2020, 'A core outcome set for trials of infant-feeding interventions to prevent childhood obesity', International Journal of Obesity, vol. 44, no. 10, pp. 2035-2043. https://doi.org/10.1038/s41366-020-0538-2

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abstract = "Background: Standardisation of outcomes measured and reported in trials of infant-feeding interventions to prevent childhood obesity is essential to evaluate and synthesise intervention effects. The aim of this study is to develop an infant-feeding core outcome set for use in randomised trials of infant-feeding interventions, with children ≤1 year old, to prevent childhood obesity. Methods: Core outcome set development followed four stages: (1) systematic review of outcomes reported in the extant literature; (2) meeting with national and international stakeholders to discuss and clarify identified outcomes; (3) e-Delphi study with national and international stakeholders to prioritise outcomes; (4) meeting with national and international stakeholders to reach consensus on outcomes. Stakeholders in stages 2–4 were paediatricians, general practitioners, nurses, midwives, non-clinician researchers, parents, dieticians, nutritionists, and childcare providers. Results: Twenty-six outcomes were identified for inclusion in the core outcome set. These were grouped in nine outcome domains: {\textquoteleft}breastfeeding and formula feeding{\textquoteright}, {\textquoteleft}introduction of solids{\textquoteright}, {\textquoteleft}parent feeding practices and styles{\textquoteright}, {\textquoteleft}parent knowledge and beliefs{\textquoteright}, {\textquoteleft}practical feeding{\textquoteright}, {\textquoteleft}food environment{\textquoteright}, {\textquoteleft}dietary intake{\textquoteright}, {\textquoteleft}perceptions of infant behaviour and preferences{\textquoteright}, and {\textquoteleft}child weight{\textquoteright}. Conclusions: The core outcome set identified in this study is the minimum that should be measured and reported in trials of infant-feeding interventions to prevent childhood obesity. This standardisation of outcomes will enable more comprehensive examination and synthesis of the effects of infant-feeding interventions to prevent childhood obesity.",

author = "Karen Matvienko-Sikar and Ciara Griffin and Colette Kelly and Caroline Heary and {Lillholm Pico Pedersen}, Majken and Niamh McGrath and Elaine Toomey and Janas Harrington and Marita Hennessy and Michelle Queally and Catherine Hayes and Jenny McSharry and Declan Devane and Molly Byrne and Kearney, {Patricia M}",

note = "Funding Information: Funding This research was supported by a Health Research Board Interdisciplinary Capacity Enhancement Award (ICE-2015-1026) and an Irish Research Council New Foundations Award (2015). CG was in receipt of a Health Research Board-Trials Methodology Research Network (HRB-TMRN) summer studentship to support this research. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature Limited.",

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AU - Matvienko-Sikar, Karen

AU - Griffin, Ciara

AU - Kelly, Colette

AU - Heary, Caroline

AU - Lillholm Pico Pedersen, Majken

AU - McGrath, Niamh

AU - Toomey, Elaine

AU - Harrington, Janas

AU - Hennessy, Marita

AU - Queally, Michelle

AU - Hayes, Catherine

AU - McSharry, Jenny

AU - Devane, Declan

AU - Byrne, Molly

AU - Kearney, Patricia M

N1 - Funding Information: Funding This research was supported by a Health Research Board Interdisciplinary Capacity Enhancement Award (ICE-2015-1026) and an Irish Research Council New Foundations Award (2015). CG was in receipt of a Health Research Board-Trials Methodology Research Network (HRB-TMRN) summer studentship to support this research. Publisher Copyright: © 2020, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Background: Standardisation of outcomes measured and reported in trials of infant-feeding interventions to prevent childhood obesity is essential to evaluate and synthesise intervention effects. The aim of this study is to develop an infant-feeding core outcome set for use in randomised trials of infant-feeding interventions, with children ≤1 year old, to prevent childhood obesity. Methods: Core outcome set development followed four stages: (1) systematic review of outcomes reported in the extant literature; (2) meeting with national and international stakeholders to discuss and clarify identified outcomes; (3) e-Delphi study with national and international stakeholders to prioritise outcomes; (4) meeting with national and international stakeholders to reach consensus on outcomes. Stakeholders in stages 2–4 were paediatricians, general practitioners, nurses, midwives, non-clinician researchers, parents, dieticians, nutritionists, and childcare providers. Results: Twenty-six outcomes were identified for inclusion in the core outcome set. These were grouped in nine outcome domains: ‘breastfeeding and formula feeding’, ‘introduction of solids’, ‘parent feeding practices and styles’, ‘parent knowledge and beliefs’, ‘practical feeding’, ‘food environment’, ‘dietary intake’, ‘perceptions of infant behaviour and preferences’, and ‘child weight’. Conclusions: The core outcome set identified in this study is the minimum that should be measured and reported in trials of infant-feeding interventions to prevent childhood obesity. This standardisation of outcomes will enable more comprehensive examination and synthesis of the effects of infant-feeding interventions to prevent childhood obesity.

AB - Background: Standardisation of outcomes measured and reported in trials of infant-feeding interventions to prevent childhood obesity is essential to evaluate and synthesise intervention effects. The aim of this study is to develop an infant-feeding core outcome set for use in randomised trials of infant-feeding interventions, with children ≤1 year old, to prevent childhood obesity. Methods: Core outcome set development followed four stages: (1) systematic review of outcomes reported in the extant literature; (2) meeting with national and international stakeholders to discuss and clarify identified outcomes; (3) e-Delphi study with national and international stakeholders to prioritise outcomes; (4) meeting with national and international stakeholders to reach consensus on outcomes. Stakeholders in stages 2–4 were paediatricians, general practitioners, nurses, midwives, non-clinician researchers, parents, dieticians, nutritionists, and childcare providers. Results: Twenty-six outcomes were identified for inclusion in the core outcome set. These were grouped in nine outcome domains: ‘breastfeeding and formula feeding’, ‘introduction of solids’, ‘parent feeding practices and styles’, ‘parent knowledge and beliefs’, ‘practical feeding’, ‘food environment’, ‘dietary intake’, ‘perceptions of infant behaviour and preferences’, and ‘child weight’. Conclusions: The core outcome set identified in this study is the minimum that should be measured and reported in trials of infant-feeding interventions to prevent childhood obesity. This standardisation of outcomes will enable more comprehensive examination and synthesis of the effects of infant-feeding interventions to prevent childhood obesity.

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DO - 10.1038/s41366-020-0538-2

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JO - International Journal of Obesity

JF - International Journal of Obesity

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