TY - JOUR
T1 - A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening
AU - van den Berg, Rosa
AU - Kooijman, Sander
AU - Noordam, Raymond
AU - Ramkisoensing, Ashna
AU - Abreu-Vieira, Gustavo
AU - Tambyrajah, Lauren L.
AU - Dijk, Wieneke
AU - Ruppert, Philip
AU - Mol, Isabel M.
AU - Kramar, Barbara
AU - Caputo, Rosanna
AU - Puig, Laura Sardón
AU - de Ruiter, Evelien M.
AU - Kroon, Jan
AU - Hoekstra, Menno
AU - van der Sluis, Ronald J.
AU - Meijer, Onno C.
AU - Willems van Dijk, Ko
AU - van Kerkhof, Linda W.M.
AU - Christodoulides, Constantinos
AU - Karpe, Fredrik
AU - Gerhart-Hines, Zachary
AU - Kersten, Sander
AU - Meijer, Johanna H.
AU - Coomans, Claudia P.
AU - van Heemst, Diana
AU - Biermasz, Nienke R.
AU - Rensen, Patrick C.N.
PY - 2018
Y1 - 2018
N2 - Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions.
AB - Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions.
KW - angiopoietin-like 4
KW - APOE3-Leiden.CETP mice
KW - brown adipose tissue
KW - circadian rhythm
KW - diurnal rhythm
KW - fatty acids
KW - lipoprotein lipase
KW - postprandial lipid response
KW - triglycerides
U2 - 10.1016/j.celrep.2018.03.004
DO - 10.1016/j.celrep.2018.03.004
M3 - Journal article
C2 - 29590620
AN - SCOPUS:85044505277
VL - 22
SP - 3521
EP - 3533
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 13
ER -