A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer; Caitrin W McDonough; Pamela J Hicks; Bong H Roh; Maria R Wing; S Sandy An; Jessica M Hester; Jessica N Cooke; Meredith A Bostrom; Megan E Rudock; Matthew E Talbert; Joshua P Lewis; Assiamira Ferrara; Lingyi Lu; Julie T Ziegler; Michele M Sale; Jasmin Divers; Daniel Shriner; Adebowale Adeyemo; Charles N Rotimi; Maggie C Y Ng; Carl D Langefeld; Barry I Freedman; Donald W Bowden; Benjamin F Voight; Laura J Scott; Valgerdur Steinthorsdottir; Andrew P Morris; Christian Dina; Ryan P Welch; Eleftheria Zeggini; Cornelia Huth; Yurii S Aulchenko; Gudmar Thorleifsson; Laura J McCulloch; Teresa Ferreira; Harald Grallert; Najaf Amin; Guanming Wu; Cristen J Willer; Soumya Raychaudhuri; Steve A McCarroll; Claudia Langenberg; Niels Grarup; Torben Jørgensen; Thomas Sparsø; Torben Hansen; Oluf Pedersen; Peter Schwarz; Fredrik Karpe; DIAGRAM Consortium

doi:10.1371/journal.pone.0029202

A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer, Caitrin W McDonough, Pamela J Hicks, Bong H Roh, Maria R Wing, S Sandy An, Jessica M Hester, Jessica N Cooke, Meredith A Bostrom, Megan E Rudock, Matthew E Talbert, Joshua P Lewis, Assiamira Ferrara, Lingyi Lu, Julie T Ziegler, Michele M Sale, Jasmin Divers, Daniel Shriner, Adebowale Adeyemo, Charles N RotimiMaggie C Y Ng, Carl D Langefeld, Barry I Freedman, Donald W Bowden, Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Soumya Raychaudhuri, Steve A McCarroll, Claudia Langenberg, Niels Grarup, Torben Jørgensen, Thomas Sparsø, Torben Hansen, Oluf Pedersen, Peter Schwarz, Fredrik Karpe, DIAGRAM Consortium

Research output: Contribution to journal › Journal article › Research › peer-review

144 Citations (Scopus)

Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n¿=¿550 independent loci) were genotyped in a replication cohort and 122 SNPs (n¿=¿98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Original language	English
Journal	P L o S One
Volume	7
Issue number	1
Pages (from-to)	e29202
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0029202
Publication status	Published - 2012

Keywords

Adult
African Americans
Aged
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Male
Meta-Analysis as Topic
Middle Aged
Polymorphism, Single Nucleotide
Validation Studies as Topic

Access to Document

10.1371/journal.pone.0029202

Cite this

Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., ... DIAGRAM Consortium (2012). A genome-wide association search for type 2 diabetes genes in African Americans. P L o S One, 7(1), e29202. https://doi.org/10.1371/journal.pone.0029202

A genome-wide association search for type 2 diabetes genes in African Americans. / Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N; Ng, Maggie C Y; Langefeld, Carl D; Freedman, Barry I; Bowden, Donald W; Voight, Benjamin F; Scott, Laura J; Steinthorsdottir, Valgerdur; Morris, Andrew P; Dina, Christian; Welch, Ryan P; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii S; Thorleifsson, Gudmar; McCulloch, Laura J; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen J; Raychaudhuri, Soumya; McCarroll, Steve A; Langenberg, Claudia; Grarup, Niels; Jørgensen, Torben; Sparsø, Thomas; Hansen, Torben ; Pedersen, Oluf ; Schwarz, Peter; Karpe, Fredrik; DIAGRAM Consortium.

In: P L o S One, Vol. 7, No. 1, 2012, p. e29202.

Research output: Contribution to journal › Journal article › Research › peer-review

Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, Voight, BF, Scott, LJ, Steinthorsdottir, V, Morris, AP, Dina, C, Welch, RP, Zeggini, E, Huth, C, Aulchenko, YS, Thorleifsson, G, McCulloch, LJ, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, CJ, Raychaudhuri, S, McCarroll, SA, Langenberg, C, Grarup, N, Jørgensen, T, Sparsø, T, Hansen, T , Pedersen, O , Schwarz, P, Karpe, F & DIAGRAM Consortium 2012, 'A genome-wide association search for type 2 diabetes genes in African Americans', P L o S One, vol. 7, no. 1, pp. e29202. https://doi.org/10.1371/journal.pone.0029202

Palmer, Nicholette D ; McDonough, Caitrin W ; Hicks, Pamela J ; Roh, Bong H ; Wing, Maria R ; An, S Sandy ; Hester, Jessica M ; Cooke, Jessica N ; Bostrom, Meredith A ; Rudock, Megan E ; Talbert, Matthew E ; Lewis, Joshua P ; Ferrara, Assiamira ; Lu, Lingyi ; Ziegler, Julie T ; Sale, Michele M ; Divers, Jasmin ; Shriner, Daniel ; Adeyemo, Adebowale ; Rotimi, Charles N ; Ng, Maggie C Y ; Langefeld, Carl D ; Freedman, Barry I ; Bowden, Donald W ; Voight, Benjamin F ; Scott, Laura J ; Steinthorsdottir, Valgerdur ; Morris, Andrew P ; Dina, Christian ; Welch, Ryan P ; Zeggini, Eleftheria ; Huth, Cornelia ; Aulchenko, Yurii S ; Thorleifsson, Gudmar ; McCulloch, Laura J ; Ferreira, Teresa ; Grallert, Harald ; Amin, Najaf ; Wu, Guanming ; Willer, Cristen J ; Raychaudhuri, Soumya ; McCarroll, Steve A ; Langenberg, Claudia ; Grarup, Niels ; Jørgensen, Torben ; Sparsø, Thomas ; Hansen, Torben ; Pedersen, Oluf ; Schwarz, Peter ; Karpe, Fredrik ; DIAGRAM Consortium. / A genome-wide association search for type 2 diabetes genes in African Americans. In: P L o S One. 2012 ; Vol. 7, No. 1. pp. e29202.

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AU - An, S Sandy

AU - Hester, Jessica M

AU - Cooke, Jessica N

AU - Bostrom, Meredith A

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AU - Freedman, Barry I

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AU - Steinthorsdottir, Valgerdur

AU - Morris, Andrew P

AU - Dina, Christian

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AU - Zeggini, Eleftheria

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AU - Aulchenko, Yurii S

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