TY - JOUR
T1 - A G(enomic)P(ositioning)S(ystem) for Plant RNAPII Transcription
AU - Leng, Xueyuan
AU - Thomas, Quentin
AU - Rasmussen, Simon Horskjær
AU - Marquardt, Sebastian
PY - 2020
Y1 - 2020
N2 - Post-translational modifications (PTMs) of histone residues shape the landscape of gene expression by modulating the dynamic process of RNA polymerase II (RNAPII) transcription. The contribution of particular histone modifications to the definition of distinct RNAPII transcription stages remains poorly characterized in plants. Chromatin immunoprecipitation combined with next-generation sequencing (ChIP-seq) resolves the genomic distribution of histone modifications. Here, we review histone PTM ChIP-seq data in Arabidopsis thaliana and find support for a Genomic Positioning System (GPS) that guides RNAPII transcription. We review the roles of histone PTM ‘readers’, ‘writers’, and ‘erasers’, with a focus on the regulation of gene expression and biological functions in plants. The distinct functions of RNAPII transcription during the plant transcription cycle may rely, in part, on the characteristic histone PTM profiles that distinguish transcription stages.
AB - Post-translational modifications (PTMs) of histone residues shape the landscape of gene expression by modulating the dynamic process of RNA polymerase II (RNAPII) transcription. The contribution of particular histone modifications to the definition of distinct RNAPII transcription stages remains poorly characterized in plants. Chromatin immunoprecipitation combined with next-generation sequencing (ChIP-seq) resolves the genomic distribution of histone modifications. Here, we review histone PTM ChIP-seq data in Arabidopsis thaliana and find support for a Genomic Positioning System (GPS) that guides RNAPII transcription. We review the roles of histone PTM ‘readers’, ‘writers’, and ‘erasers’, with a focus on the regulation of gene expression and biological functions in plants. The distinct functions of RNAPII transcription during the plant transcription cycle may rely, in part, on the characteristic histone PTM profiles that distinguish transcription stages.
U2 - 10.1016/j.tplants.2020.03.005
DO - 10.1016/j.tplants.2020.03.005
M3 - Review
C2 - 32673579
VL - 25
SP - 744
EP - 764
JO - Trends in Plant Science
JF - Trends in Plant Science
SN - 1360-1385
IS - 8
ER -