A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors

WeiSun Huang; Shengjie Hu; Xuecheng Jiang; Yuyan Weng; Yu Liu; Xue Tang; Guofeng Yang; Xun Wang; Naiyan Lu

doi:10.1088/1361-6528/acd1f2

A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors

WeiSun Huang, Shengjie Hu, Xuecheng Jiang, Yuyan Weng, Yu Liu, Xue Tang, Guofeng Yang, Xun Wang^*, Naiyan Lu

^*Corresponding author for this work

Condensed Matter Physics

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

Carcinoembryonic antigen (CEA) is a well-known biomarker and validated serum biomarker for lung cancer. We introduce a simple label-free method for CEA detection. Specific recognition of CEA was made possible by immobilizing CEA antibodies in the sensing region of AlGaN/GaN high-electron-mobility transistors. The biosensors have a detection limit of 1 fg ml(-1) in phosphate buffer solution. This approach has advantages of integration, miniaturization, low cost, and rapid detection compared to other testing methods for lung cancer and could be used in future medical diagnostics.

Original language	English
Article number	315203
Journal	Nanotechnology
Volume	34
Issue number	31
Number of pages	7
ISSN	0957-4484
DOIs	https://doi.org/10.1088/1361-6528/acd1f2
Publication status	Published - 30 Jul 2023

Keywords

AlGaN
GaN HEMT
biosensor
CEA
lung cancer screening
CANCER STATISTICS
LUNG-CANCER
BIOMARKERS

Access to Document

10.1088/1361-6528/acd1f2

Cite this

A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors. / Huang, WeiSun; Hu, Shengjie; Jiang, Xuecheng; Weng, Yuyan; Liu, Yu; Tang, Xue; Yang, Guofeng; Wang, Xun; Lu, Naiyan.

In: Nanotechnology, Vol. 34, No. 31, 315203, 30.07.2023.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Carcinoembryonic antigen (CEA) is a well-known biomarker and validated serum biomarker for lung cancer. We introduce a simple label-free method for CEA detection. Specific recognition of CEA was made possible by immobilizing CEA antibodies in the sensing region of AlGaN/GaN high-electron-mobility transistors. The biosensors have a detection limit of 1 fg ml(-1) in phosphate buffer solution. This approach has advantages of integration, miniaturization, low cost, and rapid detection compared to other testing methods for lung cancer and could be used in future medical diagnostics.",

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AU - Huang, WeiSun

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AU - Liu, Yu

AU - Tang, Xue

AU - Yang, Guofeng

AU - Wang, Xun

AU - Lu, Naiyan

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AB - Carcinoembryonic antigen (CEA) is a well-known biomarker and validated serum biomarker for lung cancer. We introduce a simple label-free method for CEA detection. Specific recognition of CEA was made possible by immobilizing CEA antibodies in the sensing region of AlGaN/GaN high-electron-mobility transistors. The biosensors have a detection limit of 1 fg ml(-1) in phosphate buffer solution. This approach has advantages of integration, miniaturization, low cost, and rapid detection compared to other testing methods for lung cancer and could be used in future medical diagnostics.

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