A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors

WeiSun Huang, Shengjie Hu, Xuecheng Jiang, Yuyan Weng, Yu Liu, Xue Tang, Guofeng Yang, Xun Wang*, Naiyan Lu

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

1 Citation (Scopus)

Abstract

Carcinoembryonic antigen (CEA) is a well-known biomarker and validated serum biomarker for lung cancer. We introduce a simple label-free method for CEA detection. Specific recognition of CEA was made possible by immobilizing CEA antibodies in the sensing region of AlGaN/GaN high-electron-mobility transistors. The biosensors have a detection limit of 1 fg ml(-1) in phosphate buffer solution. This approach has advantages of integration, miniaturization, low cost, and rapid detection compared to other testing methods for lung cancer and could be used in future medical diagnostics.

Original languageEnglish
Article number315203
JournalNanotechnology
Volume34
Issue number31
Number of pages7
ISSN0957-4484
DOIs
Publication statusPublished - 30 Jul 2023

Keywords

  • AlGaN
  • GaN HEMT
  • biosensor
  • CEA
  • lung cancer screening
  • CANCER STATISTICS
  • LUNG-CANCER
  • BIOMARKERS

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