A meta-analysis of genome-wide association studies identifies multiple longevity genes

Joris Deelen; Daniel S. Evans; Dan E. Arking; Niccola Tesi; Marianne Nygaard; Xiaomin Liu; Mary K. Wojczynski; Mary L. Biggs; Ashley van Der Spek; Gil Atzmon; Erin B. Ware; Chloe Sarnowski; Albert, V Smith; Ilkka Seppala; Heather J. Cordell; Janina Dose; Najaf Amin; Alice M. Arnold; Kristin L. Ayers; Nir Barzilai; Elizabeth J. Becker; Marian Beekman; Helene Blanche; Kaare Christensen; Lene Christiansen; Joanna C. Collerton; Sarah Cubaynes; Steven R. Cummings; Karen Davies; Birgit Debrabant; Jean-Francois Deleuze; Rachel Duncan; Jessica D. Faul; Claudio Franceschi; Pilar Galan; Vilmundur Gudnaso; Tamara B. Harris; Martijn Huisman; Mikko A. Hurme; Carol Jagger; Iris Jansen; Marja Jylha; Mika Kahonen; David Karasik; Sharon L. R. Kardia; Andrew Kingston; Thomas B. L. Kirkwood; Lenore J. Launer; Terho Lehtimaki; Wolfgang Lieb; Leo-Pekka Lyytikainen; Carmen Martin-Ruiz; Junxia Min; Almut Nebe; Anne B. Newman; Chao Nie; Ellen A. Nohr; Eric S. Orwoll; Thomas T. Perls; Michael A. Province; Bruce M. Psat; Olli T. Raitakari; Marcel J. T. Reinders; Jean-Marie Robine; Jerome, I Rotter; Paola Sebastiani; Jennifer Smith; Thorkild I. A. Sørensen; Kent D Taylor; Andre G. Uitterlinden; Wiesje van Der Flier; Sven J. van Der Lee; Cornelia M. van Duijn; Diana van Heemst; James W. Vaupel; David Weir; Kenny Ye; Yi Zeng; Wanlin Zheng; Henne Holstege; Douglas P. Kiel; Kathryn L. Lunetta; P. Eline Slagboom; Joanne M. Murabito

doi:10.1038/s41467-019-11558-2

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccola Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van Der Spek, Gil Atzmon, Erin B. Ware, Chloe Sarnowski, Albert, V Smith, Ilkka Seppala, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir BarzilaiElizabeth J. Becker, Marian Beekman, Helene Blanche, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-Francois Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnaso, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylha, Mika Kahonen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimaki, Wolfgang Lieb, Leo-Pekka Lyytikainen, Carmen Martin-Ruiz, Junxia Min, Almut Nebe, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psat, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome, I Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D Taylor, Andre G. Uitterlinden, Wiesje van Der Flier, Sven J. van Der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito

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Original language	English
Article number	3669
Journal	Nature Communications
Volume	10
Number of pages	14
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-019-11558-2
Publication status	Published - 2019

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A meta-analysis of genome-wide association studies identifies multiple longevity genesFinal published version, 1.59 MBLicence: CC BY

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Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van Der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppala, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., ... Murabito, J. M. (2019). A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nature Communications, 10, Article 3669. https://doi.org/10.1038/s41467-019-11558-2

Deelen, J, Evans, DS, Arking, DE, Tesi, N, Nygaard, M, Liu, X, Wojczynski, MK, Biggs, ML, van Der Spek, A, Atzmon, G, Ware, EB, Sarnowski, C, Smith, AV, Seppala, I, Cordell, HJ, Dose, J, Amin, N, Arnold, AM, Ayers, KL, Barzilai, N, Becker, EJ, Beekman, M, Blanche, H, Christensen, K, Christiansen, L, Collerton, JC, Cubaynes, S, Cummings, SR, Davies, K, Debrabant, B, Deleuze, J-F, Duncan, R, Faul, JD, Franceschi, C, Galan, P, Gudnaso, V, Harris, TB, Huisman, M, Hurme, MA, Jagger, C, Jansen, I, Jylha, M, Kahonen, M, Karasik, D, Kardia, SLR, Kingston, A, Kirkwood, TBL, Launer, LJ, Lehtimaki, T, Lieb, W, Lyytikainen, L-P, Martin-Ruiz, C, Min, J, Nebe, A, Newman, AB, Nie, C, Nohr, EA, Orwoll, ES, Perls, TT, Province, MA, Psat, BM, Raitakari, OT, Reinders, MJT, Robine, J-M, Rotter, JI, Sebastiani, P, Smith, J, Sørensen, TIA, D Taylor, K, Uitterlinden, AG, van Der Flier, W, van Der Lee, SJ, van Duijn, CM, van Heemst, D, Vaupel, JW, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, DP, Lunetta, KL, Slagboom, PE & Murabito, JM 2019, 'A meta-analysis of genome-wide association studies identifies multiple longevity genes', Nature Communications, vol. 10, 3669. https://doi.org/10.1038/s41467-019-11558-2

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author = "Joris Deelen and Evans, {Daniel S.} and Arking, {Dan E.} and Niccola Tesi and Marianne Nygaard and Xiaomin Liu and Wojczynski, {Mary K.} and Biggs, {Mary L.} and {van Der Spek}, Ashley and Gil Atzmon and Ware, {Erin B.} and Chloe Sarnowski and Smith, {Albert, V} and Ilkka Seppala and Cordell, {Heather J.} and Janina Dose and Najaf Amin and Arnold, {Alice M.} and Ayers, {Kristin L.} and Nir Barzilai and Becker, {Elizabeth J.} and Marian Beekman and Helene Blanche and Kaare Christensen and Lene Christiansen and Collerton, {Joanna C.} and Sarah Cubaynes and Cummings, {Steven R.} and Karen Davies and Birgit Debrabant and Jean-Francois Deleuze and Rachel Duncan and Faul, {Jessica D.} and Claudio Franceschi and Pilar Galan and Vilmundur Gudnaso and Harris, {Tamara B.} and Martijn Huisman and Hurme, {Mikko A.} and Carol Jagger and Iris Jansen and Marja Jylha and Mika Kahonen and David Karasik and Kardia, {Sharon L. R.} and Andrew Kingston and Kirkwood, {Thomas B. L.} and Launer, {Lenore J.} and Terho Lehtimaki and Wolfgang Lieb and Leo-Pekka Lyytikainen and Carmen Martin-Ruiz and Junxia Min and Almut Nebe and Newman, {Anne B.} and Chao Nie and Nohr, {Ellen A.} and Orwoll, {Eric S.} and Perls, {Thomas T.} and Province, {Michael A.} and Psat, {Bruce M.} and Raitakari, {Olli T.} and Reinders, {Marcel J. T.} and Jean-Marie Robine and Rotter, {Jerome, I} and Paola Sebastiani and Jennifer Smith and S{\o}rensen, {Thorkild I. A.} and {D Taylor}, Kent and Uitterlinden, {Andre G.} and {van Der Flier}, Wiesje and {van Der Lee}, {Sven J.} and {van Duijn}, {Cornelia M.} and {van Heemst}, Diana and Vaupel, {James W.} and David Weir and Kenny Ye and Yi Zeng and Wanlin Zheng and Henne Holstege and Kiel, {Douglas P.} and Lunetta, {Kathryn L.} and Slagboom, {P. Eline} and Murabito, {Joanne M.}",

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AU - Deelen, Joris

AU - Evans, Daniel S.

AU - Arking, Dan E.

AU - Tesi, Niccola

AU - Nygaard, Marianne

AU - Liu, Xiaomin

AU - Wojczynski, Mary K.

AU - Biggs, Mary L.

AU - van Der Spek, Ashley

AU - Atzmon, Gil

AU - Ware, Erin B.

AU - Sarnowski, Chloe

AU - Smith, Albert, V

AU - Seppala, Ilkka

AU - Cordell, Heather J.

AU - Dose, Janina

AU - Amin, Najaf

AU - Arnold, Alice M.

AU - Ayers, Kristin L.

AU - Barzilai, Nir

AU - Becker, Elizabeth J.

AU - Beekman, Marian

AU - Blanche, Helene

AU - Christensen, Kaare

AU - Christiansen, Lene

AU - Collerton, Joanna C.

AU - Cubaynes, Sarah

AU - Cummings, Steven R.

AU - Davies, Karen

AU - Debrabant, Birgit

AU - Deleuze, Jean-Francois

AU - Duncan, Rachel

AU - Faul, Jessica D.

AU - Franceschi, Claudio

AU - Galan, Pilar

AU - Gudnaso, Vilmundur

AU - Harris, Tamara B.

AU - Huisman, Martijn

AU - Hurme, Mikko A.

AU - Jagger, Carol

AU - Jansen, Iris

AU - Jylha, Marja

AU - Kahonen, Mika

AU - Karasik, David

AU - Kardia, Sharon L. R.

AU - Kingston, Andrew

AU - Kirkwood, Thomas B. L.

AU - Launer, Lenore J.

AU - Lehtimaki, Terho

AU - Lieb, Wolfgang

AU - Lyytikainen, Leo-Pekka

AU - Martin-Ruiz, Carmen

AU - Min, Junxia

AU - Nebe, Almut

AU - Newman, Anne B.

AU - Nie, Chao

AU - Nohr, Ellen A.

AU - Orwoll, Eric S.

AU - Perls, Thomas T.

AU - Province, Michael A.

AU - Psat, Bruce M.

AU - Raitakari, Olli T.

AU - Reinders, Marcel J. T.

AU - Robine, Jean-Marie

AU - Rotter, Jerome, I

AU - Sebastiani, Paola

AU - Smith, Jennifer

AU - Sørensen, Thorkild I. A.

AU - D Taylor, Kent

AU - Uitterlinden, Andre G.

AU - van Der Flier, Wiesje

AU - van Der Lee, Sven J.

AU - van Duijn, Cornelia M.

AU - van Heemst, Diana

AU - Vaupel, James W.

AU - Weir, David

AU - Ye, Kenny

AU - Zeng, Yi

AU - Zheng, Wanlin

AU - Holstege, Henne

AU - Kiel, Douglas P.

AU - Lunetta, Kathryn L.

AU - Slagboom, P. Eline

AU - Murabito, Joanne M.

PY - 2019

Y1 - 2019

U2 - 10.1038/s41467-019-11558-2

DO - 10.1038/s41467-019-11558-2

M3 - Journal article

C2 - 31413261

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

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ER -