A naturalistic glyceryl trinitrate infusion migraine model in the rat

Roshni Ramachandran; Deepak Kumar Bhatt; Kenneth Beri Ploug; Jes Olesen; Inger Jansen-Olesen; Anders Hay-Schmidt; Saurabh Gupta

doi:10.1177/0333102411430855

A naturalistic glyceryl trinitrate infusion migraine model in the rat

Roshni Ramachandran, Deepak Kumar Bhatt, Kenneth Beri Ploug, Jes Olesen, Inger Jansen-Olesen, Anders Hay-Schmidt, Saurabh Gupta

Eyepath Lab

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Abstract

Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.

Original language	English
Journal	Cephalalgia : an international journal of headache
Volume	32
Issue number	1
Pages (from-to)	73-84
Number of pages	12
DOIs	https://doi.org/10.1177/0333102411430855
Publication status	Published - Jan 2012

Keywords

Anesthesia
Animals
Blood Pressure
Disease Models, Animal
Dose-Response Relationship, Drug
Humans
Male
Migraine Disorders
Nitroglycerin
Proto-Oncogene Proteins c-fos
RNA, Messenger
Rats
Rats, Sprague-Dawley
Trigeminal Caudal Nucleus
Vasodilator Agents
Wakefulness

Access to Document

10.1177/0333102411430855

Cite this

A naturalistic glyceryl trinitrate infusion migraine model in the rat. / Ramachandran, Roshni; Bhatt, Deepak Kumar; Ploug, Kenneth Beri; Olesen, Jes; Jansen-Olesen, Inger; Hay-Schmidt, Anders; Gupta, Saurabh.

In: Cephalalgia : an international journal of headache, Vol. 32, No. 1, 01.2012, p. 73-84.

Research output: Contribution to journal › Journal article › Research › peer-review

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