TY - JOUR
T1 - A New Frontier for Nondestructive Spatial Analysis of Pharmaceutical Solid Dosage Forms: Spatially Offset Low-Frequency Raman Spectroscopy
AU - Be̅rziņš, Ka̅rlis
AU - Fraser-Miller, Sara J.
AU - Gordon, Keith C.
PY - 2021
Y1 - 2021
N2 - A new Raman subtechnique, spatially offset low-frequency Raman spectroscopy (SOLFRS), is demonstrated via an analysis of pharmaceutical solid dosage forms. Several different model systems comprised of celecoxib (a popular anti-inflammatory drug), α-lactose anhydrous stable form, α-lactose monohydrate, and polyvinylpyrrolidone (PVP) were used to represent tangible scenarios for the application of SOLFRS. Additionally, the challenges and limitations were highlighted in relation to its real-time use, and potential solutions to address them were also provided. Lastly, the future directions for this new variation of Raman spectroscopic technique were briefly discussed, including its potential for broader application in pharmaceutical analysis and other research fields.
AB - A new Raman subtechnique, spatially offset low-frequency Raman spectroscopy (SOLFRS), is demonstrated via an analysis of pharmaceutical solid dosage forms. Several different model systems comprised of celecoxib (a popular anti-inflammatory drug), α-lactose anhydrous stable form, α-lactose monohydrate, and polyvinylpyrrolidone (PVP) were used to represent tangible scenarios for the application of SOLFRS. Additionally, the challenges and limitations were highlighted in relation to its real-time use, and potential solutions to address them were also provided. Lastly, the future directions for this new variation of Raman spectroscopic technique were briefly discussed, including its potential for broader application in pharmaceutical analysis and other research fields.
U2 - 10.1021/acs.analchem.0c04960
DO - 10.1021/acs.analchem.0c04960
M3 - Journal article
C2 - 33590756
VL - 93
SP - 3698
EP - 3705
JO - Analytical Chemistry
JF - Analytical Chemistry
SN - 0974-7419
IS - 8
ER -