Abstract
Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.
Original language | English |
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Book series | Acta Neurochirurgica |
Volume | 164 |
Issue number | 1 |
Pages (from-to) | 267-271 |
Number of pages | 5 |
ISSN | 0001-6268 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
Keywords
- Brain surgery
- FG001
- Fluorescense
- Meningiomas
- Radicality
- uPar