A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

Morten Steen Salling Olesen; Lena Refsgaard; Anders Gaarsdal Holst; Anders Peter Larsen; Søren Grubb; Stig Haunsø; Jesper Hastrup Svendsen; Søren-Peter Olesen; Nicole Schmitt; Kirstine Callø

doi:10.1093/cvr/cvt028

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

Morten Steen Salling Olesen, Lena Refsgaard, Anders Gaarsdal Holst, Anders Peter Larsen, Søren Grubb, Stig Haunsø, Jesper Hastrup Svendsen, Søren-Peter Olesen, Nicole Schmitt, Kirstine Callø

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

AimsAtrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit K4.3 leading to an increase in the transient outward potassium current (I) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in K4.3 or in the auxiliary subunit K Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF.Methods and resultsTwo hundred and nine unrelated early-onset lone AF patients (

Original language	English
Journal	Cardiovascular Research
Volume	98
Issue number	3
Pages (from-to)	488-495
Number of pages	8
ISSN	0008-6363
DOIs	https://doi.org/10.1093/cvr/cvt028
Publication status	Published - 2013

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10.1093/cvr/cvt028

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillationFinal published version, 570 KB

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A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation. / Olesen, Morten Steen Salling; Refsgaard, Lena; Holst, Anders Gaarsdal; Larsen, Anders Peter; Grubb, Søren ; Haunsø, Stig ; Svendsen, Jesper Hastrup; Olesen, Søren-Peter; Schmitt, Nicole ; Callø, Kirstine.

In: Cardiovascular Research, Vol. 98, No. 3, 2013, p. 488-495.

Research output: Contribution to journal › Journal article › Research › peer-review

Olesen, Morten Steen Salling ; Refsgaard, Lena ; Holst, Anders Gaarsdal ; Larsen, Anders Peter ; Grubb, Søren ; Haunsø, Stig ; Svendsen, Jesper Hastrup ; Olesen, Søren-Peter ; Schmitt, Nicole ; Callø, Kirstine. / A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation. In: Cardiovascular Research. 2013 ; Vol. 98, No. 3. pp. 488-495.

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abstract = "AimsAtrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit K4.3 leading to an increase in the transient outward potassium current (I) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in K4.3 or in the auxiliary subunit K Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF.Methods and resultsTwo hundred and nine unrelated early-onset lone AF patients (",

author = "Olesen, {Morten Steen Salling} and Lena Refsgaard and Holst, {Anders Gaarsdal} and Larsen, {Anders Peter} and S{\o}ren Grubb and Stig Hauns{\o} and Svendsen, {Jesper Hastrup} and S{\o}ren-Peter Olesen and Nicole Schmitt and Kirstine Call{\o}",

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doi = "10.1093/cvr/cvt028",

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T1 - A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

AU - Olesen, Morten Steen Salling

AU - Refsgaard, Lena

AU - Holst, Anders Gaarsdal

AU - Larsen, Anders Peter

AU - Grubb, Søren

AU - Haunsø, Stig

AU - Svendsen, Jesper Hastrup

AU - Olesen, Søren-Peter

AU - Schmitt, Nicole

AU - Callø, Kirstine

PY - 2013

Y1 - 2013

N2 - AimsAtrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit K4.3 leading to an increase in the transient outward potassium current (I) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in K4.3 or in the auxiliary subunit K Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF.Methods and resultsTwo hundred and nine unrelated early-onset lone AF patients (

AB - AimsAtrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit K4.3 leading to an increase in the transient outward potassium current (I) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in K4.3 or in the auxiliary subunit K Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF.Methods and resultsTwo hundred and nine unrelated early-onset lone AF patients (

U2 - 10.1093/cvr/cvt028

DO - 10.1093/cvr/cvt028

M3 - Journal article

C2 - 23400760

AN - SCOPUS:84877958196

VL - 98

SP - 488

EP - 495

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 3

ER -