A novel PNA-monomer for recognition of thymine in triple-helix structures

A. Goldbech Olsen; O. Dahl; Peter E. Nielsen

doi:10.1081/NCN-120022958

A novel PNA-monomer for recognition of thymine in triple-helix structures

A. Goldbech Olsen, O. Dahl, Peter E. Nielsen

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.

Original language	English
Journal	Nucleosides, nucleotides & nucleic acids
Volume	22
Issue number	5-8
Pages (from-to)	1331-1333
Number of pages	3
DOIs	https://doi.org/10.1081/NCN-120022958
Publication status	Published - 21 Oct 2003

Keywords

Base Pairing
Binding Sites
Nucleic Acid Conformation
Peptide Nucleic Acids/chemical synthesis
Thymine

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10.1081/NCN-120022958

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Cite this

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title = "A novel PNA-monomer for recognition of thymine in triple-helix structures",

abstract = "To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.",

keywords = "Base Pairing, Binding Sites, Nucleic Acid Conformation, Peptide Nucleic Acids/chemical synthesis, Thymine",

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T1 - A novel PNA-monomer for recognition of thymine in triple-helix structures

AU - Olsen, A. Goldbech

AU - Dahl, O.

AU - Nielsen, Peter E.

PY - 2003/10/21

Y1 - 2003/10/21

N2 - To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.

AB - To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.

KW - Base Pairing

KW - Binding Sites

KW - Nucleic Acid Conformation

KW - Peptide Nucleic Acids/chemical synthesis

KW - Thymine

U2 - 10.1081/NCN-120022958

DO - 10.1081/NCN-120022958

M3 - Journal article

C2 - 14565411

SN - 1532-2335

VL - 22

SP - 1331

EP - 1333

JO - Nucleosides, nucleotides & nucleic acids

JF - Nucleosides, nucleotides & nucleic acids

IS - 5-8

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