Abstract
Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
Original language | English |
---|---|
Journal | Journal of Integrative Medicine |
Volume | 14 |
Issue number | 1 |
Pages (from-to) | 1-4 |
Number of pages | 4 |
ISSN | 2095-4964 |
DOIs | |
Publication status | Published - 2016 |
Externally published | Yes |
Keywords
- Biotechnology
- DNA, recombinant
- Nutrition
- Obesity