A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance

Jonas Møller Kristensen; Vibe Skov; Stine Juhl Petersson; Niels Ørtenblad; Jørgen Wojtaszewski; Henning Beck-Nielsen; Kurt Højlund

doi:10.1007/s00125-014-3187-y

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance

Jonas Møller Kristensen, Vibe Skov, Stine Juhl Petersson, Niels Ørtenblad, Jørgen Wojtaszewski, Henning Beck-Nielsen, Kurt Højlund

The August Krogh Section for Molecular Physiology

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Abstract

Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. We tested the hypothesis that mitochondrial oxidative metabolism is impaired in muscle of patients with inherited insulin resistance and defective insulin signalling.

Original language	English
Journal	Diabetologia
Volume	57
Issue number	5
Pages (from-to)	1006-1015
Number of pages	10
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-014-3187-y
Publication status	Published - 2014

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10.1007/s00125-014-3187-y

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A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance. / Kristensen, Jonas Møller; Skov, Vibe; Petersson, Stine Juhl; Ørtenblad, Niels; Wojtaszewski, Jørgen; Beck-Nielsen, Henning; Højlund, Kurt.

In: Diabetologia, Vol. 57, No. 5, 2014, p. 1006-1015.

Research output: Contribution to journal › Journal article › Research › peer-review

Kristensen, Jonas Møller ; Skov, Vibe ; Petersson, Stine Juhl ; Ørtenblad, Niels ; Wojtaszewski, Jørgen ; Beck-Nielsen, Henning ; Højlund, Kurt. / A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance. In: Diabetologia. 2014 ; Vol. 57, No. 5. pp. 1006-1015.

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