A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa

Lena S Andersen, Jessica F Magidson, Conall O'Cleirigh, Jessica E Remmert, Ashraf Kagee, Matthew Leaver, Dan J Stein, Steven A Safren, John Joska

Research output: Contribution to journalJournal articleResearchpeer-review

67 Citations (Scopus)

Abstract

Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa ( n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.

Original languageEnglish
JournalJournal of Health Psychology
Volume23
Issue number6
Pages (from-to)776-787
Number of pages12
ISSN1359-1053
DOIs
Publication statusPublished - May 2018
Externally publishedYes

Keywords

  • Adult
  • Anti-HIV Agents/administration & dosage
  • Cognitive Behavioral Therapy/methods
  • Culturally Competent Care
  • Depressive Disorder/nursing
  • Feasibility Studies
  • Female
  • HIV Infections/drug therapy
  • Humans
  • Male
  • Medication Adherence/psychology
  • Middle Aged
  • Nurse Practitioners
  • Patient Acceptance of Health Care
  • Pilot Projects
  • South Africa

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