A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

Matthias Manne Knopp, Natasha Gannon, Ilona Porsch, Malte Bille Rask, Niels Erik Olesen, Peter Langguth, René Holm, Thomas Rades

Research output: Contribution to journalJournal articleResearchpeer-review

20 Citations (Scopus)

Abstract

The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.

Original languageEnglish
JournalJournal of Pharmaceutical Sciences
Volume105
Issue number9
Pages (from-to)2621-2624
Number of pages4
ISSN0022-3549
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Journal Article

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