Abstract
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
Original language | English |
---|---|
Journal | Genome Research |
Volume | 25 |
Issue number | 4 |
Pages (from-to) | 459-466 |
Number of pages | 8 |
ISSN | 1088-9051 |
DOIs | |
Publication status | Published - 2015 |
Access to Document
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
A recent bottleneck of Y chromosome diversity coincides with a global change in culture. / Karmin, Monika; Saag, Lauri; Vicente, Mário; Wilson Sayres, Melissa A; Järve, Mari; Talas, Ulvi Gerst; Rootsi, Siiri; Ilumäe, Anne-Mai; Mägi, Reedik; Mitt, Mario; Pagani, Luca; Puurand, Tarmo; Faltyskova, Zuzana; Clemente, Florian; Cardona, Alexia; Metspalu, Ene; Sahakyan, Hovhannes; Yunusbayev, Bayazit; Hudjashov, Georgi; DeGiorgio, Michael; Loogväli, Eva-Liis; Eichstaedt, Christina; Eelmets, Mikk; Chaubey, Gyaneshwer; Tambets, Kristiina; Litvinov, Sergei; Mormina, Maru; Xue, Yali; Ayub, Qasim; Zoraqi, Grigor; Korneliussen, Thorfinn Sand; Akhatova, Farida; Lachance, Joseph; Tishkoff, Sarah; Momynaliev, Kuvat; Ricaut, François-Xavier; Kusuma, Pradiptajati; Razafindrazaka, Harilanto; Pierron, Denis; Cox, Murray P; Sultana, Gazi Nurun Nahar; Willerslev, Rane; Muller, Craig; Westaway, Michael; Lambert, David; Skaro, Vedrana; Kovačevic, Lejla; Turdikulova, Shahlo; Dalimova, Dilbar; Khusainova, Rita; Trofimova, Natalya; Akhmetova, Vita; Khidiyatova, Irina; Lichman, Daria V; Isakova, Jainagul; Pocheshkhova, Elvira; Sabitov, Zhaxylyk; Barashkov, Nikolay A; Nymadawa, Pagbajabyn; Mihailov, Evelin; Seng, Joseph Wee Tien; Evseeva, Irina; Migliano, Andrea Bamberg; Abdullah, Syafiq; Andriadze, George; Primorac, Dragan; Atramentova, Lubov; Utevska, Olga; Yepiskoposyan, Levon; Marjanovic, Damir; Kushniarevich, Alena; Behar, Doron M; Gilissen, Christian; Vissers, Lisenka; Veltman, Joris A; Balanovska, Elena; Derenko, Miroslava; Malyarchuk, Boris; Metspalu, Andres; Fedorova, Sardana; Eriksson, Anders; Manica, Andrea; Mendez, Fernando L; Karafet, Tatiana M; Veeramah, Krishna R; Bradman, Neil; Hammer, Michael F; Osipova, Ludmila P; Balanovsky, Oleg; Khusnutdinova, Elza K; Johnsen, Knut; Remm, Maido; Thomas, Mark G; Tyler-Smith, Chris; Underhill, Peter A; Willerslev, Eske; Nielsen, Rasmus; Metspalu, Mait; Villems, Richard; Kivisild, Toomas.
In: Genome Research, Vol. 25, No. 4, 2015, p. 459-466.Research output: Contribution to journal › Journal article › Research › peer-review
}
TY - JOUR
T1 - A recent bottleneck of Y chromosome diversity coincides with a global change in culture
AU - Karmin, Monika
AU - Saag, Lauri
AU - Vicente, Mário
AU - Wilson Sayres, Melissa A
AU - Järve, Mari
AU - Talas, Ulvi Gerst
AU - Rootsi, Siiri
AU - Ilumäe, Anne-Mai
AU - Mägi, Reedik
AU - Mitt, Mario
AU - Pagani, Luca
AU - Puurand, Tarmo
AU - Faltyskova, Zuzana
AU - Clemente, Florian
AU - Cardona, Alexia
AU - Metspalu, Ene
AU - Sahakyan, Hovhannes
AU - Yunusbayev, Bayazit
AU - Hudjashov, Georgi
AU - DeGiorgio, Michael
AU - Loogväli, Eva-Liis
AU - Eichstaedt, Christina
AU - Eelmets, Mikk
AU - Chaubey, Gyaneshwer
AU - Tambets, Kristiina
AU - Litvinov, Sergei
AU - Mormina, Maru
AU - Xue, Yali
AU - Ayub, Qasim
AU - Zoraqi, Grigor
AU - Korneliussen, Thorfinn Sand
AU - Akhatova, Farida
AU - Lachance, Joseph
AU - Tishkoff, Sarah
AU - Momynaliev, Kuvat
AU - Ricaut, François-Xavier
AU - Kusuma, Pradiptajati
AU - Razafindrazaka, Harilanto
AU - Pierron, Denis
AU - Cox, Murray P
AU - Sultana, Gazi Nurun Nahar
AU - Willerslev, Rane
AU - Muller, Craig
AU - Westaway, Michael
AU - Lambert, David
AU - Skaro, Vedrana
AU - Kovačevic, Lejla
AU - Turdikulova, Shahlo
AU - Dalimova, Dilbar
AU - Khusainova, Rita
AU - Trofimova, Natalya
AU - Akhmetova, Vita
AU - Khidiyatova, Irina
AU - Lichman, Daria V
AU - Isakova, Jainagul
AU - Pocheshkhova, Elvira
AU - Sabitov, Zhaxylyk
AU - Barashkov, Nikolay A
AU - Nymadawa, Pagbajabyn
AU - Mihailov, Evelin
AU - Seng, Joseph Wee Tien
AU - Evseeva, Irina
AU - Migliano, Andrea Bamberg
AU - Abdullah, Syafiq
AU - Andriadze, George
AU - Primorac, Dragan
AU - Atramentova, Lubov
AU - Utevska, Olga
AU - Yepiskoposyan, Levon
AU - Marjanovic, Damir
AU - Kushniarevich, Alena
AU - Behar, Doron M
AU - Gilissen, Christian
AU - Vissers, Lisenka
AU - Veltman, Joris A
AU - Balanovska, Elena
AU - Derenko, Miroslava
AU - Malyarchuk, Boris
AU - Metspalu, Andres
AU - Fedorova, Sardana
AU - Eriksson, Anders
AU - Manica, Andrea
AU - Mendez, Fernando L
AU - Karafet, Tatiana M
AU - Veeramah, Krishna R
AU - Bradman, Neil
AU - Hammer, Michael F
AU - Osipova, Ludmila P
AU - Balanovsky, Oleg
AU - Khusnutdinova, Elza K
AU - Johnsen, Knut
AU - Remm, Maido
AU - Thomas, Mark G
AU - Tyler-Smith, Chris
AU - Underhill, Peter A
AU - Willerslev, Eske
AU - Nielsen, Rasmus
AU - Metspalu, Mait
AU - Villems, Richard
AU - Kivisild, Toomas
N1 - © 2015 Karmin et al.; Published by Cold Spring Harbor Laboratory Press.
PY - 2015
Y1 - 2015
N2 - It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
AB - It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
U2 - 10.1101/gr.186684.114
DO - 10.1101/gr.186684.114
M3 - Journal article
C2 - 25770088
VL - 25
SP - 459
EP - 466
JO - Genome Research
JF - Genome Research
SN - 1088-9051
IS - 4
ER -