Age-Related Prevalence of Open Ductus Arteriosus in Full-Term Newborns

Anton Friis Mariager; Alberte Hammeken; Mikkel Malham; Anna Axelsson Raja; Anna Sellmer; Signe Levring Skjellerup; Raheel Altaf Raja; Johan Navne; Anne Sophie Sillesen; Niels Vejlstrup; Henning Bundgaard; Kasper Karmark Iversen; Ester Garne; Dorthe Lisbeth Jeppesen

doi:10.1159/000529842

Age-Related Prevalence of Open Ductus Arteriosus in Full-Term Newborns

Anton Friis Mariager^*, Alberte Hammeken, Mikkel Malham, Anna Axelsson Raja, Anna Sellmer, Signe Levring Skjellerup, Raheel Altaf Raja, Johan Navne, Anne Sophie Sillesen, Niels Vejlstrup, Henning Bundgaard, Kasper Karmark Iversen, Ester Garne, Dorthe Lisbeth Jeppesen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Background: The ductus arteriosus is part of the fetal circulation. Normally, the vessel closes during the cardiac transition. Delayed closure is associated with complications. The aim of this study was to evaluate the age-related prevalence of open ductus arteriosus in full-term neonates. Methods: Echocardiograms were collected in the population study, the Copenhagen Baby Heart Study. The present study included full-term neonates with an echocardiogram performed within 28 days after birth. All echocardiograms were reviewed to assess ductus arteriosus patency. Results: A total of 21,649 neonates were included. In neonates examined at day zero and day seven, an open ductus arteriosus was found in 36% and 0.6%, respectively. Beyond day seven, the prevalence remained stable at 0.6%. Conclusion: More than one-third of full-term neonates had an open ductus arteriosus on the first day of life, declining rapidly within the first week and stabilizing below 1% after day seven.

Original language	English
Journal	Neonatology
Volume	120
Issue number	4
Pages (from-to)	527-531
Number of pages	5
ISSN	1661-7800
DOIs	https://doi.org/10.1159/000529842
Publication status	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 S. Karger AG. All rights reserved.

Keywords

Congenital heart defect
Ductus arteriosus
Echocardiography
Neonatology
Patent ductus arteriosus

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10.1159/000529842Licence: CC BY-NC

FulltextFinal published version, 482 KBLicence: CC BY-NC

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Age-Related Prevalence of Open Ductus Arteriosus in Full-Term Newborns. / Mariager, Anton Friis; Hammeken, Alberte; Malham, Mikkel; Raja, Anna Axelsson; Sellmer, Anna; Skjellerup, Signe Levring; Raja, Raheel Altaf; Navne, Johan; Sillesen, Anne Sophie; Vejlstrup, Niels; Bundgaard, Henning ; Iversen, Kasper Karmark; Garne, Ester; Jeppesen, Dorthe Lisbeth.

In: Neonatology, Vol. 120, No. 4, 2023, p. 527-531.

Research output: Contribution to journal › Journal article › Research › peer-review

Mariager, Anton Friis ; Hammeken, Alberte ; Malham, Mikkel ; Raja, Anna Axelsson ; Sellmer, Anna ; Skjellerup, Signe Levring ; Raja, Raheel Altaf ; Navne, Johan ; Sillesen, Anne Sophie ; Vejlstrup, Niels ; Bundgaard, Henning ; Iversen, Kasper Karmark ; Garne, Ester ; Jeppesen, Dorthe Lisbeth. / Age-Related Prevalence of Open Ductus Arteriosus in Full-Term Newborns. In: Neonatology. 2023 ; Vol. 120, No. 4. pp. 527-531.

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abstract = "Background: The ductus arteriosus is part of the fetal circulation. Normally, the vessel closes during the cardiac transition. Delayed closure is associated with complications. The aim of this study was to evaluate the age-related prevalence of open ductus arteriosus in full-term neonates. Methods: Echocardiograms were collected in the population study, the Copenhagen Baby Heart Study. The present study included full-term neonates with an echocardiogram performed within 28 days after birth. All echocardiograms were reviewed to assess ductus arteriosus patency. Results: A total of 21,649 neonates were included. In neonates examined at day zero and day seven, an open ductus arteriosus was found in 36% and 0.6%, respectively. Beyond day seven, the prevalence remained stable at 0.6%. Conclusion: More than one-third of full-term neonates had an open ductus arteriosus on the first day of life, declining rapidly within the first week and stabilizing below 1% after day seven. ",

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AU - Mariager, Anton Friis

AU - Hammeken, Alberte

AU - Malham, Mikkel

AU - Raja, Anna Axelsson

AU - Sellmer, Anna

AU - Skjellerup, Signe Levring

AU - Raja, Raheel Altaf

AU - Navne, Johan

AU - Sillesen, Anne Sophie

AU - Vejlstrup, Niels

AU - Bundgaard, Henning

AU - Iversen, Kasper Karmark

AU - Garne, Ester

AU - Jeppesen, Dorthe Lisbeth

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N2 - Background: The ductus arteriosus is part of the fetal circulation. Normally, the vessel closes during the cardiac transition. Delayed closure is associated with complications. The aim of this study was to evaluate the age-related prevalence of open ductus arteriosus in full-term neonates. Methods: Echocardiograms were collected in the population study, the Copenhagen Baby Heart Study. The present study included full-term neonates with an echocardiogram performed within 28 days after birth. All echocardiograms were reviewed to assess ductus arteriosus patency. Results: A total of 21,649 neonates were included. In neonates examined at day zero and day seven, an open ductus arteriosus was found in 36% and 0.6%, respectively. Beyond day seven, the prevalence remained stable at 0.6%. Conclusion: More than one-third of full-term neonates had an open ductus arteriosus on the first day of life, declining rapidly within the first week and stabilizing below 1% after day seven.

AB - Background: The ductus arteriosus is part of the fetal circulation. Normally, the vessel closes during the cardiac transition. Delayed closure is associated with complications. The aim of this study was to evaluate the age-related prevalence of open ductus arteriosus in full-term neonates. Methods: Echocardiograms were collected in the population study, the Copenhagen Baby Heart Study. The present study included full-term neonates with an echocardiogram performed within 28 days after birth. All echocardiograms were reviewed to assess ductus arteriosus patency. Results: A total of 21,649 neonates were included. In neonates examined at day zero and day seven, an open ductus arteriosus was found in 36% and 0.6%, respectively. Beyond day seven, the prevalence remained stable at 0.6%. Conclusion: More than one-third of full-term neonates had an open ductus arteriosus on the first day of life, declining rapidly within the first week and stabilizing below 1% after day seven.

KW - Congenital heart defect

KW - Ductus arteriosus

KW - Echocardiography

KW - Neonatology

KW - Patent ductus arteriosus

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M3 - Journal article

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JO - Neonatology

JF - Neonatology

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