ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study.

Vieri Grandi; Stefano Bacci; Alessandro Corsi; Maurizio Sessa; Elisa Puliti; Nicoletta Murciano; Francesca Scavone; Pietro Cappugi; Nicola Pimpinelli

doi:10.1016/j.pdpdt.2017.12.012

ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study.

Vieri Grandi, Stefano Bacci, Alessandro Corsi, Maurizio Sessa, Elisa Puliti, Nicoletta Murciano, Francesca Scavone, Pietro Cappugi, Nicola Pimpinelli

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

Abstract

A cohort of 19 patients affected by chronic venous ulcers was recruited from our centre. A 4-mm punch biopsy from wound bed was taken before application of ALA 20% gel and repeated one hour after the first PDT irradiation. We observed a significant and progressive reduction of wounds mean volumes right after three ALA-PDT sessions (once per week; 4479.9+/-345.5mm(3) vs 34599+/-190.3mm(3), p

Original language	English
Journal	Photodiagnosis and Photodynamic Therapy
Volume	21
Pages (from-to)	252-256
Number of pages	5
ISSN	1572-1000
DOIs	https://doi.org/10.1016/j.pdpdt.2017.12.012
Publication status	Published - Mar 2018
Externally published	Yes

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10.1016/j.pdpdt.2017.12.012

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Grandi, V., Bacci, S., Corsi, A., Sessa, M., Puliti, E., Murciano, N., Scavone, F., Cappugi, P., & Pimpinelli, N. (2018). ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study. Photodiagnosis and Photodynamic Therapy, 21, 252-256. https://doi.org/10.1016/j.pdpdt.2017.12.012

ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study. / Grandi, Vieri; Bacci, Stefano; Corsi, Alessandro et al.
In: Photodiagnosis and Photodynamic Therapy, Vol. 21, 03.2018, p. 252-256.

Research output: Contribution to journal › Journal article › Research › peer-review

Grandi, V, Bacci, S, Corsi, A, Sessa, M, Puliti, E, Murciano, N, Scavone, F, Cappugi, P & Pimpinelli, N 2018, 'ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study.', Photodiagnosis and Photodynamic Therapy, vol. 21, pp. 252-256. https://doi.org/10.1016/j.pdpdt.2017.12.012

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AU - Corsi, Alessandro

AU - Sessa, Maurizio

AU - Puliti, Elisa

AU - Murciano, Nicoletta

AU - Scavone, Francesca

AU - Cappugi, Pietro

AU - Pimpinelli, Nicola

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