TY - JOUR
T1 - An antagonist of lipid A action in mammals has complex effects on lipid A induction of defence responses in the model plant Arabidopsis thaliana
AU - Erbs, Gitte
AU - Jensen, Tina Tandrup
AU - Silipo, Alba
AU - Grant, William
AU - Dow, J. Maxwell
AU - Molinaro, Antonio
AU - Parrilli, Michelangelo
AU - Newman, Mari-Anne
PY - 2008
Y1 - 2008
N2 - Lipopolysaccharides, the ubiquitous part of the outer membrane of Gram-negative bacteria, and their derivatives are recognised by plants to trigger or potentiate particular defence responses such as induction of genes encoding pathogenesis-related proteins. The molecular mechanisms of LPS perception that underpin these effects in plants are, however, unknown. Here, lipid A from Halomonas magadiensis, which is an antagonist of lipid A action in human cells, was used to investigate lipid A action in plants. Our findings offer an insight into the different structural requirements for direct induction and potentiation of plant defences by lipid A.
AB - Lipopolysaccharides, the ubiquitous part of the outer membrane of Gram-negative bacteria, and their derivatives are recognised by plants to trigger or potentiate particular defence responses such as induction of genes encoding pathogenesis-related proteins. The molecular mechanisms of LPS perception that underpin these effects in plants are, however, unknown. Here, lipid A from Halomonas magadiensis, which is an antagonist of lipid A action in human cells, was used to investigate lipid A action in plants. Our findings offer an insight into the different structural requirements for direct induction and potentiation of plant defences by lipid A.
KW - Former LIFE faculty
KW - PAMPs
KW - Halomonas magadiensis
KW - Lipid A
KW - Antagonist
KW - Arabidopsis thaliana
U2 - 10.1016/j.micinf.2008.01.008
DO - 10.1016/j.micinf.2008.01.008
M3 - Journal article
C2 - 18403233
VL - 10
SP - 571
EP - 574
JO - Microbes and Infection
JF - Microbes and Infection
SN - 1286-4579
IS - 5
ER -