An antileishmanial chalcone from Chinese licorice roots

S B Christensen, C Ming, L Andersen, U Hjørne, C E Olsen, C Cornett, T G Theander, A Kharazmi

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Abstract

A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.
Original languageEnglish
JournalPlanta Medica
Volume60
Issue number2
Pages (from-to)121-3
Number of pages2
ISSN0032-0943
Publication statusPublished - 1994

Bibliographical note

Keywords: Animals; Antiprotozoal Agents; Chalcone; Chalcones; China; Glycyrrhiza; Leishmania donovani; Magnetic Resonance Spectroscopy; Molecular Structure; Plants, Medicinal

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