TY - JOUR
T1 - An experimental evaluation of powder flow predictions in small-scale process equipment based on Jenike's hopper design methodology
AU - Søgaard, Søren Vinter
AU - Olesen, Niels Erik
AU - Hirschberg, Cosima
AU - Madsen, Morten Hannibal
AU - Allesø, Morten
AU - Garnaes, Joergen
AU - Rantanen, Jukka
PY - 2017
Y1 - 2017
N2 - This study presents an evaluation of the predicted and experimentally observed flow behavior, i.e., flow pattern and critical outlet diameter, in a tablet press hopper. Three grades of a commonly used pharmaceutical additive, microcrystalline cellulose, were used for this purpose. The prediction of the flow behavior was made by first extrapolating shear and wall friction data and, subsequently, applying these extrapolation-based data as input variables to Jenike's hopper design method. Predictions were then compared with empirical discharge experiments from a tablet press hopper and a funnel with varying outlet diameters. By application of a mixed-effect 2nd order polynomial model for the extrapolation of the wall yield locus, accurate flow pattern predictions for the tablet press hopper was made. However, the observed flow patterns were very sensitive to the powders' moisture content. The comparison of the observed and predicted critical outlet diameters showed good agreement for the powder with the best flowability when linear extrapolation of the flow function was applied. In contrast, the predicted critical outlet diameter was slightly overestimated compared to the experimentally observed diameter for the two more cohesive powders. A likely reason for this overestimation is that the flow function probably has a non-linear convex upward shape for these two powders at very small consolidation stresses. These findings illustrate the relevance of measuring shear and wall shear stresses at very small consolidation stresses to improve the flow behavior predictions for small-scale process equipment typically used during production of solid state pharmaceuticals.
AB - This study presents an evaluation of the predicted and experimentally observed flow behavior, i.e., flow pattern and critical outlet diameter, in a tablet press hopper. Three grades of a commonly used pharmaceutical additive, microcrystalline cellulose, were used for this purpose. The prediction of the flow behavior was made by first extrapolating shear and wall friction data and, subsequently, applying these extrapolation-based data as input variables to Jenike's hopper design method. Predictions were then compared with empirical discharge experiments from a tablet press hopper and a funnel with varying outlet diameters. By application of a mixed-effect 2nd order polynomial model for the extrapolation of the wall yield locus, accurate flow pattern predictions for the tablet press hopper was made. However, the observed flow patterns were very sensitive to the powders' moisture content. The comparison of the observed and predicted critical outlet diameters showed good agreement for the powder with the best flowability when linear extrapolation of the flow function was applied. In contrast, the predicted critical outlet diameter was slightly overestimated compared to the experimentally observed diameter for the two more cohesive powders. A likely reason for this overestimation is that the flow function probably has a non-linear convex upward shape for these two powders at very small consolidation stresses. These findings illustrate the relevance of measuring shear and wall shear stresses at very small consolidation stresses to improve the flow behavior predictions for small-scale process equipment typically used during production of solid state pharmaceuticals.
KW - Critical outlet diameter
KW - Flow pattern
KW - Hopper design
KW - Microcrystalline cellulose
KW - Powder flow properties
U2 - 10.1016/j.powtec.2017.08.006
DO - 10.1016/j.powtec.2017.08.006
M3 - Journal article
AN - SCOPUS:85028701622
VL - 321
SP - 523
EP - 532
JO - Powder Technology
JF - Powder Technology
SN - 0032-5910
ER -