An improved, scalable synthesis of the selective serotonin 2A receptor agonist 25CN-NBOH

Emil Marcher-Rørsted; Jitka Nykodemova; Jesper Langgaard Kristensen

doi:10.1055/a-1524-4439

An improved, scalable synthesis of the selective serotonin 2A receptor agonist 25CN-NBOH

Emil Marcher-Rørsted, Jitka Nykodemova, Jesper Langgaard Kristensen^*

^*Corresponding author for this work

Medicinal Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

74 Downloads (Pure)

Abstract

4-{2-[(2-hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and highly selective serotonin 2A receptor (5-HT2AR) agonist in 2014. The compound has since found extensive use as a pharmacological tool in a variety of in vivo and in vitro studies. In the present study, we present an improved and scalable synthesis of 25CN-NBOH making this compound readily available to the scientific community.

Original language	English
Journal	SynOpen
Volume	5
Issue number	2
Pages (from-to)	158-160
DOIs	https://doi.org/10.1055/a-1524-4439
Publication status	Published - 2021

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10.1055/a-1524-4439Licence: CC BY-NC-ND

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abstract = "4-{2-[(2-hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and highly selective serotonin 2A receptor (5-HT2AR) agonist in 2014. The compound has since found extensive use as a pharmacological tool in a variety of in vivo and in vitro studies. In the present study, we present an improved and scalable synthesis of 25CN-NBOH making this compound readily available to the scientific community.",

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AU - Marcher-Rørsted, Emil

AU - Nykodemova, Jitka

AU - Kristensen, Jesper Langgaard

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N2 - 4-{2-[(2-hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and highly selective serotonin 2A receptor (5-HT2AR) agonist in 2014. The compound has since found extensive use as a pharmacological tool in a variety of in vivo and in vitro studies. In the present study, we present an improved and scalable synthesis of 25CN-NBOH making this compound readily available to the scientific community.

AB - 4-{2-[(2-hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and highly selective serotonin 2A receptor (5-HT2AR) agonist in 2014. The compound has since found extensive use as a pharmacological tool in a variety of in vivo and in vitro studies. In the present study, we present an improved and scalable synthesis of 25CN-NBOH making this compound readily available to the scientific community.

U2 - 10.1055/a-1524-4439

DO - 10.1055/a-1524-4439

M3 - Journal article

SN - 2509-9396

VL - 5

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JO - SynOpen

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