An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

Spomenka Simovic; He Hui; Yunmei Song; Andrew K Davey; Thomas Rades; Clive A Prestidge

doi:10.1016/j.jconrel.2010.01.008

An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

Spomenka Simovic, He Hui, Yunmei Song, Andrew K Davey, Thomas Rades, Clive A Prestidge

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

Abstract

We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p

Original language	English
Journal	Journal of controlled release : official journal of the Controlled Release Society
Volume	143
Issue number	3
Pages (from-to)	367-73
Number of pages	7
DOIs	https://doi.org/10.1016/j.jconrel.2010.01.008
Publication status	Published - 2010

Keywords

Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal
Cations
Drug Carriers
Emulsions
Indomethacin
Lipids
Male
Nanoparticles
Rats
Rats, Sprague-Dawley
Silicon Dioxide

Access to Document

10.1016/j.jconrel.2010.01.008

Cite this

@article{6dd12d01a1d24b8394fccced1ccff884,

title = "An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles",

abstract = "We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p",

keywords = "Administration, Oral, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cations, Drug Carriers, Emulsions, Indomethacin, Lipids, Male, Nanoparticles, Rats, Rats, Sprague-Dawley, Silicon Dioxide",

author = "Spomenka Simovic and He Hui and Yunmei Song and Davey, {Andrew K} and Thomas Rades and Prestidge, {Clive A}",

year = "2010",

doi = "10.1016/j.jconrel.2010.01.008",

language = "English",

volume = "143",

pages = "367--73",

journal = "Journal of controlled release : official journal of the Controlled Release Society",

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T1 - An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

AU - Simovic, Spomenka

AU - Hui, He

AU - Song, Yunmei

AU - Davey, Andrew K

AU - Rades, Thomas

AU - Prestidge, Clive A

PY - 2010

Y1 - 2010

N2 - We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p

AB - We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p

KW - Administration, Oral

KW - Animals

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Cations

KW - Drug Carriers

KW - Emulsions

KW - Indomethacin

KW - Lipids

KW - Male

KW - Nanoparticles

KW - Rats

KW - Rats, Sprague-Dawley

KW - Silicon Dioxide

U2 - 10.1016/j.jconrel.2010.01.008

DO - 10.1016/j.jconrel.2010.01.008

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JO - Journal of controlled release : official journal of the Controlled Release Society

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